Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone

(2015) Sebastian Prill et al.   ARCHIVES OF TOXICOLOGY

Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms

(2015) Elishai Ezra et al.   BIOMEDICAL MICRODEVICES

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

Adverse Outcome Pathways and Drug-Induced Liver Injury Testing

(2015) Mathieu Vinken   CHEMICAL RESEARCH IN TOXICOLOGY

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment

(2015) Yeyejide Adeleye et al.   TOXICOLOGY

Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes

(2014) M. D. Nelms et al.   ARCHIVES OF TOXICOLOGY

Rotenone-induced oxidative stress and apoptosis in human liver HepG2 cells

(2013) M. A. Siddiqui et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

FutureTox: Building the Road for 21st Century Toxicology and Risk Assessment Practices

(2013) J. Craig Rowlands et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3A cells

(2012) Djomangan Adama Ouattara et al.   Molecular BioSystems

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

(2012) Jin Zhang et al.   Nature Protocols

Optical Oxygen Micro- and Nanosensors for Plant Applications

(2012) Cindy Ast et al.   SENSORS

Real-Time Monitoring of Cisplatin-Induced Cell Death

(2011) Hamed Alborzinia et al.   PLoS One

A high-throughput respirometric assay for mitochondrial biogenesis and toxicity

(2010) Craig C. Beeson et al.   ANALYTICAL BIOCHEMISTRY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer

(2009) Sven Eklund et al.   SENSORS

Mitochondrial dysfunction and delayed hepatotoxicity: another lesson from troglitazone

(2008) N. L. Julie et al.   DIABETOLOGIA