Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes
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Title
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes
Authors
Keywords
Organoids, Alzheimers disease, Immunohistochemistry techniques, Endosomes, Induced pluripotent stem cells, Enzyme-linked immunoassays, Neurons, Drug therapy
Journal
PLoS One
Volume 11, Issue 9, Pages e0161969
Publisher
Public Library of Science (PLoS)
Online
2016-09-14
DOI
10.1371/journal.pone.0161969
References
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- (2014) Madeline A Lancaster et al. Nature Protocols
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- (2014) Eliah R. Shamir et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
- (2014) Takahisa Kanekiyo et al. NEURON
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- (2014) Stephen Salloway et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2013) Madeline A. Lancaster et al. NATURE
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- (2013) Jackson Sandoe et al. NATURE NEUROSCIENCE
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- (2013) Allison D. Ebert et al. Stem Cell Research
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- (2012) Philipp Koch et al. AMERICAN JOURNAL OF PATHOLOGY
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