Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Cell and tissue-based in vitro models for improving the development of oral inhalation drug products

(2017) Marius Hittinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

(2016) Su Ryon Shin et al.   ANALYTICAL CHEMISTRY

Can Humanized Mice Predict Drug “Behavior” in Humans?

(2016) Dan Xu et al.   Annual Review of Pharmacology and Toxicology

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Immune-competent human skin disease models

(2016) Lambert I.J.C. Bergers et al.   DRUG DISCOVERY TODAY

Kidney-on-a-chip technology for renal proximal tubule tissue reconstruction

(2016) Tom T.G. Nieskens et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

Engineering a perfusable 3D human liver platform from iPS cells

(2016) Arnout Schepers et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

(2016) Hyun-Wook Kang et al.   NATURE BIOTECHNOLOGY

Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems

(2016) Fuyin Zheng et al.   Small

A Bioprinted Liver-on-a-Chip for Drug Screening Applications

(2016) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

(2016) Aleksander Skardal et al.   Jove-Journal of Visualized Experiments

Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges

(2016) Courtney M. Sakolish et al.   EBioMedicine

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs

(2015) Aleksander Skardal et al.   Acta Biomaterialia

Chemical analysis of multicellular tumour spheroids

(2015) L. E. Jamieson et al.   ANALYST

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Failures in Phase III: Causes and Consequences

(2015) B. Seruga et al.   CLINICAL CANCER RESEARCH

The application of engineered liver tissues for novel drug discovery

(2015) Christine Lin et al.   Expert Opinion on Drug Discovery

A cost-effective fluorescence mini-microscope for biomedical applications

(2015) Yu Shrike Zhang et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Pathways Involved in Interleukin-1β–Mediated Murine Cardiomyocyte Apoptosis

(2015) Yi Shen et al.   TEXAS HEART INSTITUTE JOURNAL

How multi-organ microdevices can help foster drug development

(2014) Mandy B. Esch et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomaterials for Integration with 3-D Bioprinting

(2014) Aleksander Skardal et al.   ANNALS OF BIOMEDICAL ENGINEERING

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Organs-on-a-chip: a new tool for drug discovery

(2014) Alessandro Polini et al.   Expert Opinion on Drug Discovery

Tissue-engineered autologous vaginal organs in patients: a pilot cohort study

(2014) Atlántida M Raya-Rivera et al.   LANCET

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Low cost microfluidic cell culture array using normally closed valves for cytotoxicity assay

(2014) Godfrey Pasirayi et al.   TALANTA

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

(2013) Abhinav Bhushan et al.   Stem Cell Research & Therapy

Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development

(2013) Anurag Mathur et al.   Stem Cell Research & Therapy

Evaluation of Cellular Impedance Measures of Cardiomyocyte Cultures for Drug Screening Applications

(2012) Matthew F. Peters et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

(2012) Aleksander Skardal et al.   BIOMATERIALS

Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues

(2011) Maren Drewitz et al.   Biotechnology Journal

Tissue-engineered autologous urethras for patients who need reconstruction: an observational study

(2011) Atlantida Raya-Rivera et al.   LANCET

Dynamically Crosslinked Gold Nanoparticle - Hyaluronan Hydrogels

(2010) Aleksander Skardal et al.   ADVANCED MATERIALS

Bioprinting vessel-like constructs using hyaluronan hydrogels crosslinked with tetrahedral polyethylene glycol tetracrylates

(2010) Aleksander Skardal et al.   BIOMATERIALS

Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs

(2010) Won Jin Ho et al.   CANCER SCIENCE

Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity

(2010) Jinzhou Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY