Self-organization and symmetry breaking in intestinal organoid development

YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration

(2018) Shiro Yui et al.   Cell Stem Cell

Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut

(2018) Charles A. Herring et al.   Cell Systems

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

(2018) Michal Shoshkes-Carmel et al.   NATURE

Multiplexed protein maps link subcellular organization to cellular states

(2018) Gabriele Gut et al.   SCIENCE

Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids

(2017) Thomas D. Carroll et al.   JOURNAL OF CELL SCIENCE

A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self‐renewal

(2017) Kai‐Yuan Chen et al.   Molecular Systems Biology

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate

(2017) Antonio Totaro et al.   Nature Communications

Do as I say, Not(ch) as I do: Lateral control of cell fate

(2017) Marika Sjöqvist et al.   DEVELOPMENTAL BIOLOGY

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

(2016) Mubeen Goolam et al.   CELL

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

(2016) Paul W. Tetteh et al.   Cell Stem Cell

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Wishbone identifies bifurcating developmental trajectories from single-cell data

(2016) Manu Setty et al.   NATURE BIOTECHNOLOGY

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of Transcript Variability in Single Mammalian Cells

(2015) Nico Battich et al.   CELL

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

(2015) Inês Cebola et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

(2015) Claudia Stein et al.   PLoS Genetics

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

(2014) Adrianna K. San Roman et al.   Stem Cell Reports

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

(2013) Yusuke Ohnishi et al.   NATURE CELL BIOLOGY

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Accounting for technical noise in single-cell RNA-seq experiments

(2013) Philip Brennecke et al.   NATURE METHODS

A self-organization framework for symmetry breaking in the mammalian embryo

(2013) Sebastian Wennekamp et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch in the Intestine: Regulation of Homeostasis and Pathogenesis

(2012) Taeko K. Noah et al.   Annual Review of Physiology

Restriction of intestinal stem cell expansion and the regenerative response by YAP

(2012) Evan R. Barry et al.   NATURE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells

(2011) Alexander Loewer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE