Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung

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Age, Sexual Dimorphism, and Disease Associations in the Developing Human Fetal Lung Transcriptome

(2016) Alvin T. Kho et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate

(2016) Usua Laresgoiti et al.   DEVELOPMENT

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Lung Endoderm Morphogenesis: Gasping for Form and Function

(2015) Daniel T. Swarr et al.   Annual Review of Cell and Developmental Biology

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development

(2015) D. Al Alam et al.   DEVELOPMENT

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1

(2015) Shiqi Jia et al.   DEVELOPMENTAL BIOLOGY

The miR-200 Family and Its Targets Regulate Type II Cell Differentiation in Human Fetal Lung

(2015) Houda Benlhabib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Carcinoembryonic Cell Adhesion Molecule 6 and Alveolar Epithelial Cell Markers in Lungs of Human Infants with Chronic Lung Disease

(2015) Linda W. Gonzales et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Efficient genetic engineering of human intestinal organoids using electroporation

(2015) Masayuki Fujii et al.   Nature Protocols

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development

(2015) Steven M. Hrycaj et al.   Cell Reports

Hmga2 is required for canonical WNT signaling during lung development

(2014) Indrabahadur Singh et al.   BMC BIOLOGY

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

(2014) John E. Mahoney et al.   DEVELOPMENTAL CELL

Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development

(2014) Thomas Volckaert et al.   DEVELOPMENTAL DYNAMICS

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

Gene Expression Profiling in Human Lung Development: An Abundant Resource for Lung Adenocarcinoma Prognosis

(2014) Lin Feng et al.   PLoS One

Two nested developmental waves demarcate a compartment boundary in the mouse lung

(2014) Denise Martinez Alanis et al.   Nature Communications

Modeling Human Disease with Pluripotent Stem Cells: from Genome Association to Function

(2013) Florian T. Merkle et al.   Cell Stem Cell

Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors

(2013) T. Volckaert et al.   DEVELOPMENT

Development and Regeneration of Sox2+ Endoderm Progenitors Are Regulated by a HDAC1/2-Bmp4/Rb1 Regulatory Pathway

(2013) Yi Wang et al.   DEVELOPMENTAL CELL

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny

(2013) Xiaolei Yin et al.   NATURE METHODS

Lung epithelial branching program antagonizes alveolar differentiation

(2013) D. R. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Expression of canonical WNT/β-CATENIN signaling components in the developing human lung

(2012) Mingfeng Zhang et al.   BMC DEVELOPMENTAL BIOLOGY

Genome-scale study of transcription factor expression in the branching mouse lung

(2012) John C. Herriges et al.   DEVELOPMENTAL DYNAMICS

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways

(2012) A. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

(2011) Graciana Diez-Roux et al.   PLOS BIOLOGY

HTII-280, a Biomarker Specific to the Apical Plasma Membrane of Human Lung Alveolar Type II Cells

(2010) Robert F. Gonzalez et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The NIH Roadmap Epigenomics Mapping Consortium

(2010) Bradley E Bernstein et al.   NATURE BIOTECHNOLOGY

Transcriptomic Analysis of Human Lung Development

(2009) Alvin T. Kho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells

(2009) E. L. Rawlins et al.   DEVELOPMENT

Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation

(2009) Michael S. Lan et al.   FASEB JOURNAL

A novel method for the generation of reaggregated organotypic cultures that permits juxtaposition of defined cell populations

(2009) Julie M. Sheridan et al.   GENESIS

Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy

(2009) Hans Michael Haitchi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Effect of Oxygen on the Expression of Hypoxia-Inducible Factors in Human Fetal Lung Explants

(2009) Prapapan Rajatapiti et al.   Neonatology

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH