Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene

Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden

(2019) Adrian Sturza et al.   Oxidative Medicine and Cellular Longevity

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

(2019) Helle Bogetofte et al.   Frontiers in Cellular Neuroscience

Enhancing glycolysis attenuates Parkinson’s disease progression in models and clinical databases

(2019) Rong Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects

(2019) Amica C. Müller-Nedebock et al.   NEUROCHEMISTRY INTERNATIONAL

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

(2018) Seong Su Kang et al.   EMBO JOURNAL

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum

(2018) Patrick Aldrin-Kirk et al.   NEUROBIOLOGY OF DISEASE

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Different mitochondrial genetic defects exhibit the same protein signature of metabolism in skeletal muscle of PEO and MELAS patients: A role for oxidative stress

(2018) Fulvio Santacatterina et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

(2018) Mao Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

(2018) Amy M. Smith et al.   MOVEMENT DISORDERS

POLG-related disorders and their neurological manifestations

(2018) Shamima Rahman et al.   Nature Reviews Neurology

Advances in Parkinson’s Disease: 200 Years Later

(2018) Natalia López-González Del Rey et al.   Frontiers in Neuroanatomy

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

(2018) Yangbo Feng et al.   Cancer Medicine

Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease

(2017) Maria Pia Giannoccaro et al.   MOVEMENT DISORDERS

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Is the Urea Cycle Involved in Alzheimer's Disease?

(2017) Franck Hansmannel et al.   JOURNAL OF ALZHEIMERS DISEASE

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis

(2016) R. A. Harris et al.   JOURNAL OF NEUROSCIENCE

The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity

(2016) Kaige Peng et al.   MOLECULAR NEUROBIOLOGY

Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease

(2016) Angela Pyle et al.   NEUROBIOLOGY OF AGING

Juvenile onset Parkinsonism with “pure nigral” degeneration and POLG1 mutation

(2016) Shyamal H. Mehta et al.   PARKINSONISM & RELATED DISORDERS

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

(2016) Chien Tai Hong et al.   Scientific Reports

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology

(2016) John P. M. Finberg et al.   Frontiers in Pharmacology

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

(2016) Sun Young Chung et al.   Stem Cell Reports

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

(2015) Junchao Tong et al.   NEUROBIOLOGY OF DISEASE

Generation of human pluripotent stem cell reporter lines for the isolation of and reporting on astrocytes generated from ventral midbrain and ventral spinal cord neural progenitors

(2015) Staffan Holmqvist et al.   Stem Cell Research

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease

(2014) Daniel Santos et al.   MOLECULAR NEUROBIOLOGY

Altered arginine metabolism in Alzheimer's disease brains

(2014) Ping Liu et al.   NEUROBIOLOGY OF AGING

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

(2014) Chris M. Woodard et al.   Cell Reports

Monoamine Oxidase B Prompts Mitochondrial and Cardiac Dysfunction in Pressure Overloaded Hearts

(2013) Nina Kaludercic et al.   ANTIOXIDANTS & REDOX SIGNALING

Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations

(2013) Charalampos Tzoulis et al.   BRAIN

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

(2012) Nicole Exner et al.   EMBO JOURNAL

Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production

(2012) Jordan T. Newington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Genetic analysis of two Japanese families with progressive external ophthalmoplegia and parkinsonism

(2011) Kazunori Sato et al.   JOURNAL OF NEUROLOGY

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

(2011) Frederick P Bellinger et al.   Molecular Neurodegeneration

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein pathology and Parkinsonism associated withPOLG1mutations and multiple mitochondrial DNA deletions

(2008)   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Parkinsonism associated with the homozygous W748S mutation in the POLG1 gene

(2008) A.M. Remes et al.   PARKINSONISM & RELATED DISORDERS