Vascularized Liver Organoids Generated Using Induced Hepatic Tissue and Dynamic Liver-Specific Microenvironment as a Drug Testing Platform

Thermoplastic microfluidic devices for targeted chemical and biological applications

(2017) Dan Voicu et al.   RSC Advances

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

(2017) Daiki Nakamori et al.   Scientific Reports

Triboelectric Nanogenerator Accelerates Highly Efficient Nonviral Direct Conversion and In Vivo Reprogramming of Fibroblasts to Functional Neuronal Cells

(2016) Yoonhee Jin et al.   ADVANCED MATERIALS

Cardiac-Derived Extracellular Matrix Enhances Cardiogenic Properties of Human Cardiac Progenitor Cells

(2016) Roberto Gaetani et al.   CELL TRANSPLANTATION

Rare genetic variants in cellular transporters, metabolic enzymes and nuclear receptors can be important determinants of interindividual differences in drug response

(2016) Mikael Kozyra et al.   GENETICS IN MEDICINE

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

(2016) Christopher Goldring et al.   HEPATOLOGY

A 3D alcoholic liver disease model on a chip

(2016) JaeSeo Lee et al.   Integrative Biology

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems

(2016) Robim M. Rodrigues et al.   TOXICOLOGY LETTERS

Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming

(2016) Kyung Tae Lim et al.   Cell Reports

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments

(2016) Bo Wang et al.   Stem Cells Translational Medicine

Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition

(2016) Giuseppe Pettinato et al.   Scientific Reports

Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system

(2015) Kisuk Yang et al.   BIOMATERIALS

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration

(2015) Caryn L. Elsegood et al.   HEPATOLOGY

Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture

(2015) K. C. Hribar et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation

(2015) Wei Song et al.   Scientific Reports

Bottom-Up Engineering of Well-Defined 3D Microtissues Using Microplatforms and Biomedical Applications

(2015) Geon Hui Lee et al.   Advanced Healthcare Materials

Microfluidics-Based in Vivo Mimetic Systems for the Study of Cellular Biology

(2014) Donghyuk Kim et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hepatocyte Cocultures with Endothelial Cells and Fibroblasts on Micropatterned Fibrous Mats to Promote Liver-Specific Functions and Capillary Formation Capabilities

(2014) Yaowen Liu et al.   BIOMACROMOLECULES

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

(2014) Yuanyuan Du et al.   Cell Stem Cell

Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes

(2014) Pengyu Huang et al.   Cell Stem Cell

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

(2014) Falguni Pati et al.   Nature Communications

Liver Extracellular Matrix Providing Dual Functions of Two-Dimensional Substrate Coating and Three-Dimensional Injectable Hydrogel Platform for Liver Tissue Engineering

(2013) Jung Seung Lee et al.   BIOMACROMOLECULES

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency

(2011) Stuart M. Chambers et al.   CELL

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

The FoxA factors in organogenesis and differentiation

(2010) Klaus H Kaestner   CURRENT OPINION IN GENETICS & DEVELOPMENT

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

(2010) Paul M. van Midwoud et al.   LAB ON A CHIP

Human stem cells and drug screening: opportunities and challenges

(2010) Allison D. Ebert et al.   NATURE REVIEWS DRUG DISCOVERY

Injectable Materials for the Treatment of Myocardial Infarction and Heart Failure: The Promise of Decellularized Matrices

(2010) Jennifer M. Singelyn et al.   Journal of Cardiovascular Translational Research

Naturally derived myocardial matrix as an injectable scaffold for cardiac tissue engineering

(2009) Jennifer M. Singelyn et al.   BIOMATERIALS

Polymorphism of human cytochrome P450 enzymes and its clinical impact

(2009) Shu-Feng Zhou et al.   DRUG METABOLISM REVIEWS

Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors

(2009) F Yang et al.   GENE THERAPY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles

(2009) Fan Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of Human Hepatocyte Function In Vitro by Liver-Derived Extracellular Matrix Gels

(2009) Tiffany L. Sellaro et al.   TISSUE ENGINEERING PART A

Extraction and Assembly of Tissue-Derived Gels for Cell Culture and Tissue Engineering

(2008) Shiri Uriel et al.   TISSUE ENGINEERING PART C-METHODS