Disease modelling in human organoids

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

(2019) Gitte Berkers et al.   Cell Reports

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

(2019) Jasper Mullenders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

(2019) Benedetta Artegiani et al.   Cell Stem Cell

Lgr5+ stem/progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool

(2019) Nicole Prior et al.   DEVELOPMENT

Development of a functional thyroid model based on an organoid culture system

(2018) Yoshiyuki Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

A guide to using functional magnetic resonance imaging to study Alzheimer's disease in animal models

(2018) Mazen Asaad et al.   Disease Models & Mechanisms

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment

(2018) Herve Tiriac et al.   GASTROINTESTINAL ENDOSCOPY

Human gastric cancer modelling using organoids

(2018) Therese Seidlitz et al.   GUT

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract

(2018) Wyatt Lanik et al.   Viruses-Basel

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

(2018) Cindy J.M. Loomans et al.   Stem Cell Reports

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

(2018) Xiaodun Li et al.   Nature Communications

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

(2018) Wanlu Cao et al.   CARCINOGENESIS

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

The secret lives of cancer cell lines

(2018) Robert E. Hynds et al.   Disease Models & Mechanisms

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Engineering induction of singular neural rosette emergence within hPSC-derived tissues

(2018) Gavin T Knight et al.   eLife

25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model

(2017) Chunfeng Li et al.   IMMUNITY

Wnt/β-catenin promotes gastric fundus specification in mice and humans

(2017) Kyle W. McCracken et al.   NATURE

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

(2017) Karl R Koehler et al.   NATURE BIOTECHNOLOGY

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

(2017) Fotios Sampaziotis et al.   NATURE MEDICINE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells

(2017) Fotios Sampaziotis et al.   Nature Protocols

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells

(2017) Takanori Takebe et al.   Cell Reports

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

(2017) Marko Z Nikolić et al.   eLife

Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine

(2017) Christopher R. Schlieve et al.   Stem Cell Reports

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

(2017) Hedwig S. Kruitwagen et al.   Stem Cell Reports

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

(2017) Jie Zhou et al.   Science Advances

The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication

(2017) Carolina Q. Sacramento et al.   Scientific Reports

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells

(2017) Karl J. Wahlin et al.   Scientific Reports

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

(2016) David A. Parfitt et al.   Cell Stem Cell

Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells

(2016) Hongmei Mou et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids

(2016) Sina Bartfeld   DEVELOPMENTAL BIOLOGY

Chromosomal abnormalities in hepatic cysts point to novel polycystic liver disease genes

(2016) Edgar S Wills et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

(2016) Miao Xu et al.   NATURE MEDICINE

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Understanding kidney morphogenesis to guide renal tissue regeneration

(2016) Melissa H. Little et al.   Nature Reviews Nephrology

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Human Salivary Gland Stem Cells Functionally Restore Radiation Damaged Salivary Glands

(2016) Sarah Pringle et al.   STEM CELLS

Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

(2016) Chikafumi Ozone et al.   Nature Communications

A bioengineered niche promotes in vivo engraftment and maturation of pluripotent stem cell derived human lung organoids

(2016) Briana R Dye et al.   eLife

Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals

(2016) Martti Maimets et al.   Stem Cell Reports

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

(2016) Ewart W. Kuijk et al.   Scientific Reports

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells

(2015) Anita A. Kurmann et al.   Cell Stem Cell

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Quantification of regenerative potential in primary human mammary epithelial cells

(2015) J. R. Linnemann et al.   DEVELOPMENT

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

(2015) Sina Bartfeld et al.   GASTROENTEROLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Generation of stomach tissue from mouse embryonic stem cells

(2015) Taka-aki K. Noguchi et al.   NATURE CELL BIOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

(2015) Mirjana Kessler et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

(2015) Sathidpak Nantasanti et al.   Stem Cell Reports

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo

(2014) M. Zernicka-Goetz et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

(2013) Yoshiki Sasai   Cell Stem Cell

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Artificial three-dimensional niches deconstruct pancreas development in vitro

(2013) C. Greggio et al.   DEVELOPMENT

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration

(2013) H. M. Takase et al.   GENES & DEVELOPMENT

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

The haplotype-resolved genome and epigenome of the aneuploid HeLa cancer cell line

(2013) Andrew Adey et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells

(2013) Yun Xia et al.   NATURE CELL BIOLOGY

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salivary gland development: A template for regeneration

(2013) Vaishali N. Patel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Lineage tracing of the endoderm during oral development

(2012) Michaela Rothova et al.   DEVELOPMENTAL DYNAMICS

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Generation of functional thyroid from embryonic stem cells

(2012) Francesco Antonica et al.   NATURE

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell