Emerging organoid models: leaping forward in cancer research

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

(2019) Yoshimasa Saito et al.   Cell Reports

ROCK2 inhibition triggers the collective invasion of colorectal adenocarcinomas

(2019) Fotine Libanje et al.   EMBO JOURNAL

Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures

(2019) Carminia Maria Della Corte et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

(2018) Susan Tsai et al.   BMC CANCER

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells

(2018) Rocío G. Sampayo et al.   JOURNAL OF CELL BIOLOGY

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Studying Tumor-ReacTive T Cells: A Personalized Organoid Model

(2018) Ugur Sahin   Cell Stem Cell

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Modeling of Patient-Derived Xenografts in Colorectal Cancer

(2017) Anastasia Katsiampoura et al.   MOLECULAR CANCER THERAPEUTICS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

The potential of organoids in urological cancer research

(2017) Shangqian Wang et al.   Nature Reviews Urology

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

(2017) M Nakayama et al.   ONCOGENE

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

(2017) Jarno Drost et al.   SCIENCE

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

(2017) Niklas K. Finnberg et al.   Oncotarget

The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness

(2017) Amrita Singh Chandhoke et al.   Oncotarget

Tumor engraftment in patient-derived xenografts of pancreatic ductal adenocarcinoma is associated with adverse clinicopathological features and poor survival

(2017) Ilaria Pergolini et al.   PLoS One

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling

(2016) Hua Gao et al.   CELL

Tumor Organoids Fill the Niche

(2016) Noah F. Shroyer   Cell Stem Cell

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

(2016) T T Vellinga et al.   ONCOGENE

Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

(2016) Weijie Peng et al.   TRENDS IN BIOTECHNOLOGY

Towards Single-Step Biofabrication of Organs on a Chip via 3D Printing

(2016) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC

(2016) Michael J. Schell et al.   Nature Communications

Rapid 3D Extrusion of Synthetic Tumor Microenvironments

(2015) Joshua M. Grolman et al.   ADVANCED MATERIALS

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Organoid development in cancer genome discovery

(2015) Dong Gao et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Prostate cancer organoids: a potential new tool for testing drug sensitivity

(2015) Ian Vela et al.   Expert Review of Anticancer Therapy

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Heat-shock factor 2 is a suppressor of prostate cancer invasion

(2015) J K Björk et al.   ONCOGENE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

3D cell culture systems modeling tumor growth determinants in cancer target discovery

(2014) Claudio R. Thoma et al.   ADVANCED DRUG DELIVERY REVIEWS

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer

(2014) Kai Wang et al.   NATURE GENETICS

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

(2014) Xingnan Li et al.   NATURE MEDICINE

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells

(2014) Anja Torsvik et al.   Cancer Medicine

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Genetic reconstitution of tumorigenesis in primary intestinal cells

(2013) K. Onuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

(2013) Shunqiang Li et al.   Cell Reports

Classifying collective cancer cell invasion

(2012) Peter Friedl et al.   NATURE CELL BIOLOGY