Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development

(2017) Loïc Broix et al.   HUMAN MOLECULAR GENETICS

PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation

(2017) Tatsuo Miyamoto et al.   HUMAN MOLECULAR GENETICS

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly

(2017) Paraskevi Sgourdou et al.   Scientific Reports

Glial-Specific Functions of Microcephaly Protein WDR62 and Interaction with the Mitotic Kinase AURKA Are Essential for Drosophila Brain Growth

(2017) Nicholas R. Lim et al.   Stem Cell Reports

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Cilium assembly and disassembly

(2016) Irma Sánchez et al.   NATURE CELL BIOLOGY

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

The Microcephaly-Associated Protein Wdr62/CG7337 Is Required to Maintain Centrosome Asymmetry in Drosophila Neuroblasts

(2016) Anjana Ramdas Nair et al.   Cell Reports

The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation

(2015) Tatsuo Miyamoto et al.   Cell Reports

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

(2015) Andrew Kodani et al.   eLife

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Microtubule-Depolymerizing Kinesins

(2013) Claire E. Walczak et al.   Annual Review of Cell and Developmental Biology

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

A genomic toolkit to investigate kinesin and myosin motor function in cells

(2013) Zoltan Maliga et al.   NATURE CELL BIOLOGY

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What disorders of cortical development tell us about the cortex: one plus one does not always make two

(2011) M Chiara Manzini et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Spindle Poisons and Cell Fate: A Tale of Two Pathways

(2011) D. R. Matson et al.   MOLECULAR INTERVENTIONS

Do cilia put brakes on the cell cycle?

(2011) Peter K. Jackson   NATURE CELL BIOLOGY

Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors

(2011) Aiqun Li et al.   NATURE CELL BIOLOGY

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway

(2011) Ralph Gruber et al.   NATURE CELL BIOLOGY

Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry

(2011) Sehyun Kim et al.   NATURE CELL BIOLOGY

A new subtype of progenitor cell in the mouse embryonic neocortex

(2011) Xiaoqun Wang et al.   NATURE NEUROSCIENCE

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cdk5rap2 exposes the centrosomal root of microcephaly syndromes

(2011) Timothy L. Megraw et al.   TRENDS IN CELL BIOLOGY

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

(2010) Jose A. Barrera et al.   DEVELOPMENTAL CELL

Developmental genetics of vertebrate glial–cell specification

(2010) David H. Rowitch et al.   NATURE

Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations

(2010) Kaya Bilgüvar et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

(2010) Timothy W Yu et al.   NATURE GENETICS

WDR62 is associated with the spindle pole and is mutated in human microcephaly

(2010) Adeline K Nicholas et al.   NATURE GENETICS

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

Cdk4/CyclinD1 Overexpression in Neural Stem Cells Shortens G1, Delays Neurogenesis, and Promotes the Generation and Expansion of Basal Progenitors

(2009) Christian Lange et al.   Cell Stem Cell

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS