Specification of positional identity in forebrain organoids

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Morphogen interpretation: concentration, time, competence, and signaling dynamics

(2017) Andreas Sagner et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Stem Cell Models of Human Brain Development

(2016) Iva Kelava et al.   Cell Stem Cell

Differential developmental strategies by Sonic hedgehog in thalamus and hypothalamus

(2016) Yuanfeng Zhang et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

(2016) Faranak Fattahi et al.   NATURE

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

A viral strategy for targeting and manipulating interneurons across vertebrate species

(2016) Jordane Dimidschstein et al.   NATURE NEUROSCIENCE

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells

(2015) F. T. Merkle et al.   DEVELOPMENT

Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome

(2015) Robert Blassberg et al.   HUMAN MOLECULAR GENETICS

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

(2014) Federico González et al.   Cell Stem Cell

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

(2014) Adam M Fontebasso et al.   NATURE GENETICS

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Release and transportation of Hedgehog molecules

(2012) Pascal P Thérond   CURRENT OPINION IN CELL BIOLOGY

In vitro organogenesis in three dimensions: self-organising stem cells

(2012) Y. Sasai et al.   DEVELOPMENT

Lipoproteins in Drosophila melanogaster—Assembly, Function, and Influence on Tissue Lipid Composition

(2012) Wilhelm Palm et al.   PLoS Genetics

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Comparison of Pretectal Genoarchitectonic Pattern between Quail and Chicken Embryos

(2011) Paloma Merchán et al.   Frontiers in Neuroanatomy

Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration

(2010) Toshiyuki Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells

(2009) Tabea Dierker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

(2008) Vladimir L Katanaev et al.   EMBO JOURNAL

Hhat Is a Palmitoylacyltransferase with Specificity forN-Palmitoylation of Sonic Hedgehog

(2008) John A. Buglino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE