An Efficient Intestinal Organoid System of Direct Sorting to Evaluate Stem Cell Competition in Vitro

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

(2017) Shunsuke Kon et al.   NATURE CELL BIOLOGY

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Differences in Radiation Dose Response between Small and Large Intestinal Crypts

(2016) Kensuke Otsuka et al.   RADIATION RESEARCH

The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia

(2015) Hajime Yamauchi et al.   Scientific Reports

A novel in vitro survival assay of small intestinal stem cells after exposure to ionizing radiation

(2014) Motohiro Yamauchi et al.   JOURNAL OF RADIATION RESEARCH

The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

(2014) Je-Hoon Song et al.   Cell Reports

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

(2013) Robert P. Fordham et al.   Cell Stem Cell

Ionizing Radiation Leads to the Replacement andde novoProduction of Colonic Lgr5+Stem Cells

(2013) Kensuke Otsuka et al.   RADIATION RESEARCH

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

Stem cell competition: finding balance in the niche

(2013) Rachel R. Stine et al.   TRENDS IN CELL BIOLOGY

Cell wars: regulation of cell survival and proliferation by cell competition

(2012) Silvia Vivarelli et al.   Essays in Biochemistry

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

(2012) Shiro Yui et al.   NATURE MEDICINE

Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues

(2011) Benjamin D. Simons et al.   CELL

Universal patterns of stem cell fate in cycling adult tissues

(2011) A. M. Klein et al.   DEVELOPMENT

Stem cell self-renewal in intestinal crypt

(2011) Benjamin D. Simons et al.   EXPERIMENTAL CELL RESEARCH

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift

(2010) C. Lopez-Garcia et al.   SCIENCE

Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate

(2009) Laurens G. van der Flier et al.   CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE