Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

(2017) Zonghui Ding et al.   MOLECULAR CANCER RESEARCH

The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles

(2016) Ehud Wainstein et al.   CURRENT OPINION IN CELL BIOLOGY

Clinical impact of tumour biology in the management of gastroesophageal cancer

(2016) Florian Lordick et al.   Nature Reviews Clinical Oncology

Extracellular region of epidermal growth factor receptor: a potential target for anti-EGFR drug discovery

(2016) A Dokala et al.   ONCOGENE

Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis

(2016) Yoshihisa Okuchi et al.   PLoS One

Abstract 118: EGFL6, a potential novel ligand of EGFR, play roles in Nasopharyngeal cacinoma metastasis through establishing invasive and long-distant metastatic niche by paracrine and autocrine

(2015) Jinna Chen et al.   CANCER RESEARCH

Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

(2015) Breanne Sparta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metastatic Colorectal Cancer: Current State and Future Directions

(2015) Marwan G. Fakih   JOURNAL OF CLINICAL ONCOLOGY

The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors

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Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis

(2014) Anne E. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanism and consequences of RAF kinase activation by small-molecule inhibitors

(2014) M Holderfield et al.   BRITISH JOURNAL OF CANCER

Fucci2a:A bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice

(2014) Richard Lester Mort et al.   CELL CYCLE

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

(2014) Rei Mizuno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

Tumor adaptation and resistance to RAF inhibitors

(2013) Piro Lito et al.   NATURE MEDICINE

The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

(2012) Anne E. Powell et al.   CELL

Live Imaging of Protein Kinase Activities in Transgenic Mice Expressing FRET Biosensors

(2012) Yuji Kamioka et al.   CELL STRUCTURE AND FUNCTION

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

(2012) Vivian W. Y. Wong et al.   NATURE CELL BIOLOGY

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

(2010) Murat Cirit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

(2010) Elizabeth J. Joslin et al.   Molecular BioSystems

Inhibition of LRIG3 gene expression via RNA interference modulates the proliferation, cell cycle, cell apoptosis, adhesion and invasion of glioblastoma cell (GL15)

(2009) Mingjun Cai et al.   CANCER LETTERS

Filamin A Modulates Kinase Activation and Intracellular Trafficking of Epidermal Growth Factor Receptors in Human Melanoma Cells

(2009) Jennifer L. Fiori et al.   ENDOCRINOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

(2009) Kazuhiro Aoki et al.   Nature Protocols

The epidermal growth factor receptor family: Biology driving targeted therapeutics

(2008) M. J. Wieduwilt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ERBBs in the gastrointestinal tract: Recent progress and new perspectives

(2008) William H. Fiske et al.   EXPERIMENTAL CELL RESEARCH