RNA granules: functional compartments or incidental condensates?

Functional partitioning of transcriptional regulators by patterned charge blocks

(2023) Heankel Lyons et al.   CELL

Germ granules in development

(2023) Laura Thomas et al.   DEVELOPMENT

Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes

(2023) Yutaro Hori et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interface resistance of biomolecular condensates

(2023) Yoyo Jiang et al.   BIOPHYSICAL JOURNAL

CD-CODE: crowdsourcing condensate database and encyclopedia

(2023) Nadia Rostam et al.   NATURE METHODS

Functional organization of RNA polymerase II in nuclear subcompartments

(2022) Karsten Rippe et al.   CURRENT OPINION IN CELL BIOLOGY

On the role of phase separation in the biogenesis of membraneless compartments

(2022) Andrea Musacchio   EMBO JOURNAL

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

(2022) Haneul Yoo et al.   MOLECULAR CELL

Technological advances in super-resolution microscopy to study cellular processes

(2022) Charles Bond et al.   MOLECULAR CELL

Spatial organization of transcribed eukaryotic genes

(2022) Susanne Leidescher et al.   NATURE CELL BIOLOGY

Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development

(2022) Mainak Bose et al.   CELL

RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules

(2022) Carolyn J Decker et al.   EMBO JOURNAL

Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

(2022) Hendrik Glauninger et al.   MOLECULAR CELL

Transcription activation is enhanced by multivalent interactions independent of phase separation

(2022) Jorge Trojanowski et al.   MOLECULAR CELL

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription

(2022) Shasha Chong et al.   MOLECULAR CELL

Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate

(2022) Ian Seim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function

(2022) Emily L. Starke et al.   PLoS Genetics

Germ granules and gene regulation in the Caenorhabditis elegans germline

(2022) Carolyn M Phillips et al.   GENETICS

Production of nascent ribosome precursors within the nucleolar microenvironment of Saccharomyces cerevisiae

(2022) Samantha Lin et al.   GENETICS

Eukaryotic mRNA Decapping Activation

(2022) Elva Vidya et al.   Frontiers in Genetics

Identification of embryonic RNA granules that act as sites of mRNA translation after changing their physical properties

(2022) Keisuke Sato et al.   iScience

Phase Separation Properties in Transcriptional Organization

(2022) Chenghao Guo et al.   BIOCHEMISTRY

Nuclear speckles – a driving force in gene expression

(2022) Gabriel P. Faber et al.   JOURNAL OF CELL SCIENCE

A conceptual framework for understanding phase separation and addressing open questions and challenges

(2022) Tanja Mittag et al.   MOLECULAR CELL

Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I

(2022) Aida Rodríguez-Nuevo et al.   NATURE

The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates

(2022) John Paul Tsu Ouyang et al.   NATURE CELL BIOLOGY

Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions

(2022) Mrityunjoy Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mRNAs sequestered in stress granules recover nearly completely for translation

(2022) Sarada Das et al.   RNA Biology

Imaging-associated stress causes divergent phase transitions of RNA-binding proteins in the Caenorhabditis elegans germ line

(2022) Mohamed T Elaswad et al.   G3-Genes Genomes Genetics

Large RNP granules in Caenorhabditis elegans oocytes have distinct phases of RNA-binding proteins

(2022) Mohamed T Elaswad et al.   G3-Genes Genomes Genetics

It’s Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control

(2022) Dylan M. Parker et al.   Frontiers in Genetics

Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates in Xenopus oocytes

(2022) Sarah E. Cabral et al.   iScience

Specialized germline P-bodies are required to specify germ cell fate in C. elegans embryos

(2022) Madeline Cassani et al.   DEVELOPMENT

“Structure”-function relationships in eukaryotic transcription factors: The role of intrinsically disordered regions in gene regulation

(2022) John J. Ferrie et al.   MOLECULAR CELL

Capillary forces generated by biomolecular condensates

(2022) Bernardo Gouveia et al.   NATURE

RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation

(2022) Emily L. Spaulding et al.   Nature Communications

The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies

(2022) Edward Courchaine et al.   Nature Communications

Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles

(2022) Emma Lacroix et al.   Frontiers in Molecular Biosciences

A guide to membraneless organelles and their various roles in gene regulation

(2022) Tetsuro Hirose et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fixation can change the appearance of phase separation in living cells

(2022) Shawn Irgen-Gioro et al.   eLife

Phase Separation during Germline Development

(2021) Chun So et al.   TRENDS IN CELL BIOLOGY

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation

(2021) Fabian Morales-Polanco et al.   iScience

Human nucleoli comprise multiple constrained territories, tethered to individual chromosomes

(2021) Hazel Mangan et al.   GENES & DEVELOPMENT

In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates

(2021) Weirui Ma et al.   eLife

Stress granules: regulators or by‐products?

(2021) Daniel Mateju et al.   FEBS Journal

Towards a ‘Spot On’ Understanding of Transcription in the Nucleus

(2021) Simona Patange et al.   JOURNAL OF MOLECULAR BIOLOGY

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

(2021) Ryan W. Tibble et al.   Nature Chemical Biology

Intracellular mRNA transport and localized translation

(2021) Sulagna Das et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The rDNA is biomolecular condensate formed by polymer–polymer phase separation and is sequestered in the nucleolus by transcription and R-loops

(2021) Josh Lawrimore et al.   NUCLEIC ACIDS RESEARCH

Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules

(2021) Adam E. Sundby et al.   TRENDS IN CELL BIOLOGY

Energetic and structural features of SARS-CoV-2 N-protein co-assemblies with nucleic acids

(2021) Huaying Zhao et al.   iScience

Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription

(2021) Megan Palacio et al.   JOURNAL OF MOLECULAR BIOLOGY

NORAD-induced Pumilio phase separation is required for genome stability

(2021) Mahmoud M. Elguindy et al.   NATURE

Regulation of biomolecular condensates by interfacial protein clusters

(2021) Andrew W. Folkmann et al.   SCIENCE

In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli

(2021) Philipp S. Erdmann et al.   Nature Communications

Higher-order organization of biomolecular condensates

(2021) Charlotte M. Fare et al.   Open Biology

Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

(2021) Helen Schmidt et al.   eLife

RNA‐binding proteins and translation control in angiogenesis

(2021) Madeleine R. Smith et al.   FEBS Journal

G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities

(2021) Xiaomei He et al.   NUCLEIC ACIDS RESEARCH

Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches

(2021) Alvaro Castells-Garcia et al.   NUCLEIC ACIDS RESEARCH

What are the distinguishing features and size requirements of biomolecular condensates and their implications for RNA-containing condensates?

(2021) Julie D. Forman-Kay et al.   RNA

Weak multivalent biomolecular interactions: a strength versus numbers tug of war with implications for phase partitioning

(2021) Xavier Darzacq et al.   RNA

A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly

(2021) Xiuzhen Chen et al.   RNA

Nuage condensates: accelerators or circuit breakers for sRNA silencing pathways?

(2021) John Paul Tsu Ouyang et al.   RNA

RNA multimerization as an organizing force for liquid–liquid phase separation

(2021) Philip C. Bevilacqua et al.   RNA

How do protein domains of low sequence complexity work?

(2021) Masato Kato et al.   RNA

Pathological phase transitions in ALS-FTD impair dynamic RNA–protein granules

(2021) Natalia B. Nedelsky et al.   RNA

Are stress granules the RNA analogs of misfolded protein aggregates?

(2021) Nina Ripin et al.   RNA

Liquid-Liquid Phase Separation: Unraveling the Enigma of Biomolecular Condensates in Microbial Cells

(2021) Zixu Gao et al.   Frontiers in Microbiology

Reversible Kinetic Trapping of FUS Biomolecular Condensates

(2021) Sayantan Chatterjee et al.   Advanced Science

RNA Droplets

(2020) Kevin Rhine et al.   Annual Review of Biophysics

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

(2020) Chih-Yung S Lee et al.   eLife

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters

(2020) Tatjana Trcek et al.   MOLECULAR CELL

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

(2020) Aditi Shukla et al.   NATURE

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs

(2020) John D. Laver et al.   Cell Reports

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

(2020) Kevin I Manage et al.   eLife

Dynamic metastable long-living droplets formed by sticker-spacer proteins

(2020) Srivastav Ranganathan et al.   eLife

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage

(2020) Dylan M. Parker et al.   DEVELOPMENT

mRNA localization mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis

(2020) Jaclyn M. Fingerhut et al.   JOURNAL OF CELL BIOLOGY

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

(2020) Wenmin Xing et al.   eLife

Whence Blobs? Phylogenetics of functional protein condensates

(2020) Iva Pritišanac et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Emerging Roles for Phase Separation in Plants

(2020) Ryan J. Emenecker et al.   DEVELOPMENTAL CELL

Phase Separation in Germ Cells and Development

(2020) Anne E. Dodson et al.   DEVELOPMENTAL CELL

Natural selection on the phase-separation properties of FUS during 160 million years of mammalian evolution

(2020) Pouria Dasmeh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Nucleated transcriptional condensates amplify gene expression

(2020) Ming-Tzo Wei et al.   NATURE CELL BIOLOGY

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

(2020) Nina Eiermann et al.   Viruses-Basel

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes

(2020) Liguo Zhang et al.   GENOME RESEARCH

Protein condensates as aging Maxwell fluids

(2020) Louise Jawerth et al.   SCIENCE

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Multicolour single-molecule tracking of mRNA interactions with RNP granules

(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

(2019) Raghav R. Poudyal et al.   Nature Communications

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth

(2019) Mariavittoria Pizzinga et al.   JOURNAL OF CELL BIOLOGY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain

(2019) Masato Kato et al.   CELL

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

(2019) David Trombley McSwiggen et al.   eLife

Molecular interactions underlying liquid−liquid phase separation of the FUS low-complexity domain

(2019) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nucleolus functions as a phase-separated protein quality control compartment

(2019) F. Frottin et al.   SCIENCE

Germ granules in Drosophila

(2019) Tatjana Trcek et al.   TRAFFIC

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

(2019) Markus Sauer et al.   Nature Communications

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery

(2019) Benjamin Götte et al.   PLoS Pathogens

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

(2019) Mahmoud M Elguindy et al.   eLife

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

(2019) Ya-Cheng Liao et al.   CELL

The travels of mRNAs in neurons: do they know where they are going?

(2019) Sulagna Das et al.   CURRENT OPINION IN NEUROBIOLOGY

Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules

(2019) Elisabeth A. Marnik et al.   GENETICS

Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus

(2019) Run-Wen Yao et al.   MOLECULAR CELL

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

(2019) Tae Hun Kim et al.   SCIENCE

Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis

(2019) Bernhard Hampoelz et al.   CELL

Nucleolus: A Liquid Droplet Compartment for Misbehaving Proteins

(2019) Simon Alberti et al.   CURRENT BIOLOGY

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

Gene expression amplification by nuclear speckle association

(2019) Jiah Kim et al.   JOURNAL OF CELL BIOLOGY

Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates

(2019) Paulo L. Onuchic et al.   Scientific Reports

Availability of splicing factors in the nucleoplasm can regulate the release of mRNA from the gene after transcription

(2019) Hodaya Hochberg-Laufer et al.   PLoS Genetics

Molecular structure in biomolecular condensates

(2019) Ivan Peran et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Formation of Chromatin Subcompartments by Phase Separation

(2018) Fabian Erdel et al.   BIOPHYSICAL JOURNAL

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

(2018) Sofia A. Quinodoz et al.   CELL

mTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding

(2018) M. Delarue et al.   CELL

Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules

(2018) Matthew G. Niepielko et al.   CURRENT BIOLOGY

Dynamic regulation of nucleolar architecture

(2018) Attila Németh et al.   CURRENT OPINION IN CELL BIOLOGY

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS

(2018) Hannah M. Burgess et al.   JOURNAL OF VIROLOGY

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

(2018) Nancy Standart et al.   TRENDS IN GENETICS

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

(2018) Guadalupe Sepulveda et al.   eLife

Context-dependent deposition and regulation of mRNAs in P-bodies

(2018) Congwei Wang et al.   eLife

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus Replication

(2018) Keisuke Nakagawa et al.   JOURNAL OF VIROLOGY

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

(2018) Mathias Munschauer et al.   NATURE

Extreme disorder in an ultrahigh-affinity protein complex

(2018) Alessandro Borgia et al.   NATURE

Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons

(2018) Benita Turner-Bridger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins

(2018) Ethan J. Greenblatt et al.   SCIENCE

Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci

(2018) Celja J. Uebel et al.   PLoS Genetics

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction

(2018) Anthony Khong et al.   JOURNAL OF CELL BIOLOGY

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Dynamics of mRNA Turnover Revealed by Single-Molecule Imaging in Single Cells

(2017) Ivana Horvathova et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping

(2017) Stefan Schütz et al.   NUCLEIC ACIDS RESEARCH

Numerous interactions act redundantly to assemble a tunable size of P bodies inSaccharomyces cerevisiae

(2017) Bhalchandra S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing

(2017) Li Jiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

RNA-Based Coacervates as a Model for Membraneless Organelles: Formation, Properties, and Interfacial Liposome Assembly

(2016) William M. Aumiller et al.   LANGMUIR

Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters

(2016) Timothy J. Nott et al.   Nature Chemistry

ATPase activity of the DEAD-box protein Dhh1 controls processing body formation

(2016) Christopher Frederick Mugler et al.   eLife

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

(2016) Jarrett Smith et al.   eLife

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

PolyQ-dependent RNA–protein assemblies control symmetry breaking

(2015) ChangHwan Lee et al.   JOURNAL OF CELL BIOLOGY

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

RNA transcription modulates phase transition-driven nuclear body assembly

(2015) Joel Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1

(2015) Lucas C. Reineke et al.   mBio

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice

(2014) S. Nakagawa et al.   DEVELOPMENT

The Stress Granule Protein G3BP1 Recruits Protein Kinase R To Promote Multiple Innate Immune Antiviral Responses

(2014) Lucas C. Reineke et al.   JOURNAL OF VIROLOGY

Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

(2014) Ouissame Bounedjah et al.   NUCLEIC ACIDS RESEARCH

G3BP1, G3BP2 and CAPRIN1 Are Required for Translation of Interferon Stimulated mRNAs and Are Targeted by a Dengue Virus Non-coding RNA

(2014) Katell Bidet et al.   PLoS Pathogens

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

(2014) Jennifer T Wang et al.   eLife

DEAD-box helicases as integrators of RNA, nucleotide and protein binding

(2013) Andrea A. Putnam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Bacterial Cytoplasm Has Glass-like Properties and Is Fluidized by Metabolic Activity

(2013) Bradley R. Parry et al.   CELL

NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

(2013) Tetsuro Hirose et al.   MOLECULAR BIOLOGY OF THE CELL

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline

(2012) C. M. Phillips et al.   GENES & DEVELOPMENT

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

RNA catalysis through compartmentalization

(2012) Christopher A. Strulson et al.   Nature Chemistry

Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion

(2012) Cyrille Girard et al.   Nature Communications

Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing

(2011) Joseph R. Patterson et al.   DEVELOPMENTAL BIOLOGY

PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans

(2011) Momoyo Hanazawa et al.   JOURNAL OF CELL BIOLOGY

The DEAD-Box Protein Ded1 Modulates Translation by the Formation and Resolution of an eIF4F-mRNA Complex

(2011) Angela Hilliker et al.   MOLECULAR CELL

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells

(2010) U. Sheth et al.   DEVELOPMENT

Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

(2010) Magdalena Strzelecka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

Bucky Ball Organizes Germ Plasm Assembly in Zebrafish

(2009) Franck Bontems et al.   CURRENT BIOLOGY

Small Cajal Body–specific RNAs of Drosophila Function in the Absence of Cajal Bodies

(2009) Svetlana Deryusheva et al.   MOLECULAR BIOLOGY OF THE CELL

Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA

(2009) Ling-Ling Chen et al.   MOLECULAR CELL

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

(2009) Alexei A. Aravin et al.   PLoS Genetics

Temporal and Spatial Control of Germ-Plasm RNAs

(2008) Prashanth Rangan et al.   CURRENT BIOLOGY

Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos

(2008) Christopher M. Gallo et al.   DEVELOPMENTAL BIOLOGY

Crystal Structure of Human Edc3 and Its Functional Implications

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