The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates

Automated and customizable quantitative image analysis of whole C. elegans germlines

(2021) Erik Toraason et al.   GENETICS

Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency

(2021) Stefano Vavassori et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease

(2021) Tom Le Voyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piRNAs coordinate poly(UG) tailing to prevent aberrant and perpetual gene silencing

(2021) Aditi Shukla et al.   CURRENT BIOLOGY

Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans

(2021) Shimiao Liao et al.   NUCLEIC ACIDS RESEARCH

Biallelic ZNFX1 variants are associated with a spectrum of immuno‐hematological abnormalities

(2021) Salem Alawbathani et al.   CLINICAL GENETICS

Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

(2020) Giorgia Barucci et al.   NATURE CELL BIOLOGY

Mitochondria Associated Germinal Structures in Spermatogenesis: piRNA Pathway Regulation and Beyond

(2020) Xiaoli Wang et al.   Cells

poly(UG)-tailed RNAs in genome protection and epigenetic inheritance

(2020) Aditi Shukla et al.   NATURE

A Conserved NRDE-2/MTR-4 Complex Mediates Nuclear RNAi in Caenorhabditis elegans

(2020) Gang Wan et al.   GENETICS

Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

(2020) Lianna Schwartz-Orbach et al.   eLife

H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

(2019) Itamar Lev et al.   eLife

Multigenerational Regulation of the Caenorhabditis elegans Chromatin Landscape by Germline Small RNAs

(2019) Natasha E. Weiser et al.   Annual Review of Genetics

P Granules Protect RNA Interference Genes from Silencing by piRNAs

(2019) John Paul T. Ouyang et al.   DEVELOPMENTAL CELL

Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS

(2019) Yao Wang et al.   NATURE CELL BIOLOGY

P-Bodies: Composition, Properties, and Functions

(2018) Yang Luo et al.   BIOCHEMISTRY

Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline

(2018) En-Zhi Shen et al.   CELL

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

The surveillance of pre-mRNA splicing is an early step inC. elegansRNAi of endogenous genes

(2018) Martin A. Newman et al.   GENES & DEVELOPMENT

ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals

(2018) Takao Ishidate et al.   MOLECULAR CELL

A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi

(2018) Fei Xu et al.   Cell Reports

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans

(2017) Alexandre Paix et al.   METHODS

Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

(2017) Natallia Kalinava et al.   Epigenetics & Chromatin

One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing

(2016) Benjamin Czech et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Ribonuclease Coordinates siRNA Amplification and mRNA Cleavage during RNAi

(2015) Hsin-Yue Tsai et al.   CELL

The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans

(2015) Hui Mao et al.   CURRENT BIOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

RNAi and Heterochromatin Assembly

(2015) Robert Martienssen et al.   Cold Spring Harbor Perspectives in Biology

Tertiary siRNAs Mediate Paramutation in C. elegans

(2015) Alexandra Sapetschnig et al.   PLoS Genetics

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

(2013) Stephane E. Castel et al.   NATURE REVIEWS GENETICS

piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans

(2012) Alyson Ashe et al.   CELL

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Protection from Feed-Forward Amplification in an Amplified RNAi Mechanism

(2012) Julia Pak et al.   CELL

MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline

(2012) C. M. Phillips et al.   GENES & DEVELOPMENT

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence

(2012) Yuval Tabach et al.   NATURE

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

(2012) Sam Guoping Gu et al.   NATURE GENETICS

Visualization of single mRNAs reveals temporal association of proteins with microRNA-regulated mRNA

(2011) Joseph D. Shih et al.   NUCLEIC ACIDS RESEARCH

mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans

(2011) N. O. Burton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pre-mRNA–Associating Factor Links Endogenous siRNAs to Chromatin Regulation

(2011) Kirk B. Burkhart et al.   PLoS Genetics

Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

(2010) Shouhong Guang et al.   NATURE

The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

(2009) Julie M. Claycomb et al.   CELL

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Distinct Argonaute-Mediated 22G-RNA Pathways Direct Genome Surveillance in the C. elegans Germline

(2009) Weifeng Gu et al.   MOLECULAR CELL

Transmission Dynamics of Heritable Silencing Induced by Double-Stranded RNA in Caenorhabditis elegans

(2008) Rosa M. Alcazar et al.   GENETICS

An Argonaute Transports siRNAs from the Cytoplasm to the Nucleus

(2008) S. Guang et al.   SCIENCE