Protein-based condensation mechanisms drive the assembly of RNA-rich P granules

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

(2020) Chih-Yung S Lee et al.   eLife

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Mechanisms and Regulation of RNA Condensation in RNP Granule Formation

(2020) Devin Tauber et al.   TRENDS IN BIOCHEMICAL SCIENCES

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage

(2020) Dylan M. Parker et al.   DEVELOPMENT

Membraneless organelles: P granules in C. elegans

(2019) Elisabeth A. Marnik et al.   TRAFFIC

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Harnessing biomolecular condensates in living cells

(2019) Hideki Nakamura et al.   JOURNAL OF BIOCHEMISTRY

Germ granules in Drosophila

(2019) Tatjana Trcek et al.   TRAFFIC

Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules

(2018) Matthew G. Niepielko et al.   CURRENT BIOLOGY

RNA-protein interactions in an unstructured context

(2018) Bojan Zagrovic et al.   FEBS LETTERS

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

(2018) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

(2018) Elke F. Roovers et al.   DEVELOPMENTAL CELL

The P Granules of C. elegans: A Genetic Model for the Study of RNA–Protein Condensates

(2018) Geraldine Seydoux   JOURNAL OF MOLECULAR BIOLOGY

Formation and dynamics of cytoplasmic domains and their genetic regulation during the zebrafish oocyte-to-embryo transition

(2018) Ricardo Fuentes et al.   MECHANISMS OF DEVELOPMENT

Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

(2018) Kathryn E Kistler et al.   eLife

Single molecule dynamics of the P granule scaffold MEG-3 in the C. elegans zygote

(2018) Youjun Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans

(2017) Alexandre Paix et al.   METHODS

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

PGL germ granule assembly protein is a base-specific, single-stranded RNase

(2016) Scott T. Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes

(2016) Michelle A Carmell et al.   eLife

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

(2016) Jarrett Smith et al.   eLife

Structure-specific nucleic acid recognition by L-motifs and their diverse roles in expression and regulation of the genome

(2015) Roopa Thapar   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

A Unique HMG-Box Domain of Mouse Maelstrom Binds Structured RNA but Not Double Stranded DNA

(2015) Pavol Genzor et al.   PLoS One

Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans

(2014) Jennifer T Wang et al.   eLife

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans

(2011) Momoyo Hanazawa et al.   JOURNAL OF CELL BIOLOGY

P Granule Assembly and Function in Caenorhabditis elegans Germ Cells

(2010) D. Updike et al.   JOURNAL OF ANDROLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE