Keeping up with the condensates: The retention, gain, and loss of nuclear membrane-less organelles

HSF-1 displays nuclear stress body formation in multiple tissues in Caenorhabditis elegans upon stress and following the transition to adulthood

(2021) Andrew Deonarine et al.   CELL STRESS & CHAPERONES

A nervous system-specific subnuclear organelle in Caenorhabditis elegans

(2021) Kenneth Pham et al.   GENETICS

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Local translation in nuclear condensate amyloid bodies

(2021) Phaedra R. Theodoridis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability

(2021) Lilian C. Russo et al.   Frontiers in Cell and Developmental Biology

Paraspeckle nuclear condensates: Global sensors of cell stress?

(2021) Finn McCluggage et al.   BIOESSAYS

Nuclear speckles: dynamic hubs of gene expression regulation

(2021) İbrahim Avşar Ilık et al.   FEBS Journal

LncRNA NEAT1 induces autophagy through epigenetic regulation of autophagy‐related gene expression in neuroglial cells

(2021) Ziqiang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

(2021) Pamela J. McMillan et al.   Acta Neuropathologica Communications

Evolutionary conservation of systemic and reversible amyloid aggregation

(2021) Emma Lacroix et al.   JOURNAL OF CELL SCIENCE

A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly

(2021) Xiuzhen Chen et al.   RNA

Liquidity Is a Critical Determinant for Selective Autophagy of Protein Condensates

(2020) Akinori Yamasaki et al.   MOLECULAR CELL

LncRNA NEAT1 promotes proliferation of chondrocytes via down‐regulation of miR‐16‐5p in osteoarthritis

(2020) Dan Li et al.   JOURNAL OF GENE MEDICINE

Speculating on the Roles of Nuclear Speckles: How RNA‐Protein Nuclear Assemblies Affect Gene Expression

(2020) Sarah E. Hasenson et al.   BIOESSAYS

The emergence of phase separation as an organizing principle in bacteria

(2020) Christopher A. Azaldegui et al.   BIOPHYSICAL JOURNAL

Biomolecular Condensates and Gene Activation in Development and Disease

(2020) Benjamin R. Sabari   DEVELOPMENTAL CELL

Organization and function of paraspeckles

(2020) Yang Wang et al.   Essays in Biochemistry

SON and SRRM2 are essential for nuclear speckle formation

(2020) İbrahim Avşar Ilik et al.   eLife

Protein quality control by the proteasome and autophagy: A regulatory role of ubiquitin and liquid-liquid phase separation

(2020) Linlin Lei et al.   MATRIX BIOLOGY

Phase-to-Phase With Nucleoli – Stress Responses, Protein Aggregation and Novel Roles of RNA

(2019) Leena Latonen   Frontiers in Cellular Neuroscience

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

(2019) Pengfei Zhang et al.   Nature Communications

NEAT1 is overexpressed in Parkinson’s disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress

(2019) Alon Simchovitz et al.   FASEB JOURNAL

RNA is a critical element for the sizing and the composition of phase-separated RNA–protein condensates

(2019) Marina Garcia-Jove Navarro et al.   Nature Communications

Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer

(2019) Emiliano Matos-Perdomo et al.   Cells

Stress‐specific aggregation of proteins in the amyloid bodies

(2019) Dane Marijan et al.   FEBS LETTERS

Human antiviral protein MxA forms novel metastable membrane-less cytoplasmic condensates exhibiting rapid reversible tonicity-driven phase transitions

(2019) Deodate Davis et al.   JOURNAL OF VIROLOGY

Nucleolus: A Central Hub for Nuclear Functions

(2019) Olga V. Iarovaia et al.   TRENDS IN CELL BIOLOGY

Lnc RNA ‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation

(2019) Kensuke Ninomiya et al.   EMBO JOURNAL

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

Organization and Function of Non-dynamic Biomolecular Condensates

(2018) Jeffrey B. Woodruff et al.   TRENDS IN BIOCHEMICAL SCIENCES

Paraspeckles: Where Long Noncoding RNA Meets Phase Separation

(2018) Archa H. Fox et al.   TRENDS IN BIOCHEMICAL SCIENCES

Plant Nucleolar Stress Response, a New Face in the NAC-Dependent Cellular Stress Responses

(2018) Iwai Ohbayashi et al.   Frontiers in Plant Science

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis

(2018) Miling Wang et al.   Cell Reports

The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response

(2018) S. Mohammad Lellahi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural biology of G protein‐coupled receptor signaling complexes

(2018) X. Edward Zhou et al.   PROTEIN SCIENCE

Protein gradients on the nucleoid position the carbon-fixing organelles of cyanobacteria

(2018) Joshua S MacCready et al.   eLife

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

(2017) Jingyi Fei et al.   JOURNAL OF CELL SCIENCE

Crosstalk between the nucleolus and the DNA damage response

(2017) L. M. Ogawa et al.   Molecular BioSystems

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for a Role of ANAC082 as a Ribosomal Stress Response Mediator Leading to Growth Defects and Developmental Alterations in Arabidopsis

(2017) Iwai Ohbayashi et al.   PLANT CELL

Architectural RNAs (arcRNAs): A class of long noncoding RNAs that function as the scaffold of nuclear bodies

(2016) Takeshi Chujo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nuclear speckles are detention centers for transcripts containing expanded CAG repeats

(2016) Martyna O. Urbanek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Adaptation to Stressors by Systemic Protein Amyloidogenesis

(2016) Timothy E. Audas et al.   DEVELOPMENTAL CELL

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

(2016) Jason A. West et al.   JOURNAL OF CELL BIOLOGY

Cajal bodies in neurons

(2016) Miguel Lafarga et al.   RNA Biology

A charge-dependent mechanism is responsible for the dynamic accumulation of proteins inside nucleoli

(2015) Yana R. Musinova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

(2015) E Conrad et al.   CELL DEATH AND DIFFERENTIATION

Dynamics of hnRNPs and omega speckles in normal and heat shocked live cell nuclei of Drosophila melanogaster

(2015) Anand K. Singh et al.   CHROMOSOMA

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

(2015) S. B. Miller et al.   EMBO JOURNAL

Position-specific binding of FUS to nascent RNA regulates mRNA length

(2015) Akio Masuda et al.   GENES & DEVELOPMENT

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Bacterial microcompartments and the modular construction of microbial metabolism

(2015) Cheryl A. Kerfeld et al.   TRENDS IN MICROBIOLOGY

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

(2015) Irene Gallina et al.   Nature Communications

Principles of protein targeting to the nucleolus

(2015) Robert M Martin et al.   Nucleus

Principles of protein targeting to the nucleolus

(2015) Robert M Martin et al.   Nucleus

The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice

(2014) S. Nakagawa et al.   DEVELOPMENT

Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability

(2014) Y. Li et al.   JOURNAL OF CELL SCIENCE

Meiotic long non-coding meiRNA accumulates as a dot at its genetic locus facilitated by Mmi1 and plays as a decoy to lure Mmi1

(2014) Y. Shichino et al.   Open Biology

Nucleolar stress with and without p53

(2014) Allison James et al.   Nucleus

NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies

(2013) Tetsuro Hirose et al.   MOLECULAR BIOLOGY OF THE CELL

Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA

(2012) Timothy E. Audas et al.   MOLECULAR CELL

Where no RNA polymerase has gone before

(2012) Mathieu D. Jacob et al.   Nucleus

Forty years of the 93D puff of Drosophila melanogaster

(2011) Subhash C Lakhotia   JOURNAL OF BIOSCIENCES

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy

(2011) Kazuo Fushimi et al.   Protein & Cell

The traffic of proteins between nucleolar organizer regions and prenucleolar bodies governs the assembly of the nucleolus at exit of mitosis

(2011) Eleonora Muro et al.   Nucleus

Assembly and disassembly of the nucleolus during the cell cycle

(2011) Danièle Hernandez-Verdun   Nucleus

Phosphorylation and the Cajal body: Modification in search of function

(2010) Michael D. Hebert   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization and prediction of protein nucleolar localization sequences

(2010) Michelle S. Scott et al.   NUCLEIC ACIDS RESEARCH

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

(2010) L Latonen et al.   ONCOGENE

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

Nuclear Stress Bodies

(2010) G. Biamonti et al.   Cold Spring Harbor Perspectives in Biology

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Paraspeckles

(2010) A. H. Fox et al.   Cold Spring Harbor Perspectives in Biology

The nucleolus: structure/function relationship in RNA metabolism

(2010) Danièle Hernandez-Verdun et al.   Wiley Interdisciplinary Reviews-RNA

PML nuclear bodies and their spatial relationships in the mammalian cell nucleus

(2009) Elizabeth Batty   Frontiers in Bioscience-Landmark

PML nuclear bodies as sites of epigenetic regulation

(2009) Dora Torok   Frontiers in Bioscience-Landmark

Coilin Is Essential for Cajal Body Organization in Drosophila melanogaster

(2009) Ji-Long Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

(2009) I. Draskovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

The Cajal body

(2008) Glenn E. Morris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

UBE2I (UBC9), a SUMO-Conjugating Enzyme, Localizes to Nuclear Speckles and Stimulates Transcription in Mouse Oocytes1

(2008) Motomasa Ihara et al.   BIOLOGY OF REPRODUCTION

Identification of Genes That Function in the Biogenesis and Localization of Small Nucleolar RNAs in Saccharomyces cerevisiae

(2008) H. Qiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of apoptosis by PML and the PML-NBs

(2008) R Bernardi et al.   ONCOGENE