Eukaryotic mRNA Decapping Activation

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition

(2022) Lenno Krenning et al.   eLife

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome

(2021) Isioma I.I. Enwerem et al.   RNA

EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics

(2021) Jeremiah J Bearss et al.   EMBO REPORTS

Biological implications of decapping: beyond bulk mRNA decay

(2021) Fivos Borbolis et al.   FEBS Journal

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

(2021) Brian D. Freibaum et al.   JOURNAL OF CELL BIOLOGY

Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation

(2021) Ryan W. Tibble et al.   Nature Chemical Biology

microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development

(2021) Vinay K Mayya et al.   NUCLEIC ACIDS RESEARCH

The expanding field of non-canonical RNA capping: new enzymes and mechanisms

(2021) Jana Wiedermannová et al.   Royal Society Open Science

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Coordinated repression of pro-differentiation genes via P-bodies and transcription maintains Drosophila intestinal stem cell identity

(2021) Kasun Buddika et al.   CURRENT BIOLOGY

The mRNA decapping complex is buffered by nuclear localization

(2021) Kiril Tishinov et al.   JOURNAL OF CELL SCIENCE

The Mimivirus L375 Nudix enzyme hydrolyzes the 5’ mRNA cap

(2021) Grace Kago et al.   PLoS One

Drosophila decapping protein 2 modulates the formation of cortical F-actin for germ plasm assembly

(2020) Yi-Mei Lee et al.   DEVELOPMENTAL BIOLOGY

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

(2020) Nico Battich et al.   SCIENCE

Global deletion of the RNA decapping enzyme Dcp2 postnatally in male mice results in infertility

(2020) Rui-Min Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Profiling of Cellular Substrates of Human Dcp2

(2020) Yang Luo et al.   BIOCHEMISTRY

4E-T-bound mRNAs are stored in a silenced and deadenylated form

(2020) Felix Räsch et al.   GENES & DEVELOPMENT

Pby1 is a direct partner of the Dcp2 decapping enzyme

(2020) Clément Charenton et al.   NUCLEIC ACIDS RESEARCH

DXO/Rai1 enzymes remove 5′-end FAD and dephospho-CoA caps on RNAs

(2020) Selom K Doamekpor et al.   NUCLEIC ACIDS RESEARCH

Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex

(2020) Joseph H Lobel et al.   RNA

The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

(2020) Michael Zavortink et al.   eLife

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

(2020) Wenmin Xing et al.   eLife

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

(2020) William R Brothers et al.   eLife

Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance

(2020) Minseon Kim et al.   GENETICS

Metabolic labeling of RNA using multiple ribonucleoside analogs enables the simultaneous evaluation of RNA synthesis and degradation rates

(2020) Kentaro Kawata et al.   GENOME RESEARCH

Poxvirus-encoded decapping enzymes promote selective translation of viral mRNAs

(2020) Fernando Cantu et al.   PLoS Pathogens

The multifaceted eukaryotic cap structure

(2020) Jerry Pelletier et al.   Wiley Interdisciplinary Reviews-RNA

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Ciphers and Executioners: How 3′-Untranslated Regions Determine the Fate of Messenger RNAs

(2019) Vinay K. Mayya et al.   Frontiers in Genetics

The maternal-to-zygotic transition revisited

(2019) Nadine L. Vastenhouw et al.   DEVELOPMENT

Genome wide analysis of 3′ UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish

(2019) Charles E. Vejnar et al.   GENOME RESEARCH

A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

(2019) Chung-Te Chang et al.   NUCLEIC ACIDS RESEARCH

Molecular basis for GIGYF–Me31B complex assembly in 4EHP-mediated translational repression

(2019) Daniel Peter et al.   GENES & DEVELOPMENT

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

(2019) Ying Yang et al.   MOLECULAR CELL

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

(2019) Jin Wang et al.   NUCLEIC ACIDS RESEARCH

The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis

(2019) Bruno Di Stefano et al.   Cell Stem Cell

Pat1 activates late steps in mRNA decay by multiple mechanisms

(2019) Joseph H. Lobel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular RNA surveillance in health and disease

(2019) Sandra L. Wolin et al.   SCIENCE

GC content shapes mRNA storage and decay in human cells

(2019) Maïté Courel et al.   eLife

P-Bodies: Composition, Properties, and Functions

(2018) Yang Luo et al.   BIOCHEMISTRY

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes

(2018) Tobias Brandmann et al.   EMBO JOURNAL

Viral manipulation of host mRNA decay

(2018) Liang Guo et al.   Future Virology

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos

(2018) Hyeshik Chang et al.   MOLECULAR CELL

Controlling nuclear RNA levels

(2018) Manfred Schmid et al.   NATURE REVIEWS GENETICS

Control of mRNA decapping by autoinhibition

(2018) David R Paquette et al.   NUCLEIC ACIDS RESEARCH

Eukaryotic RNA 5′-End NAD + Capping and DeNADding

(2018) Megerditch Kiledjian   TRENDS IN CELL BIOLOGY

P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage

(2018) Nancy Standart et al.   TRENDS IN GENETICS

The Interplay between the RNA Decay and Translation Machinery in Eukaryotes

(2018) Adam M. Heck et al.   Cold Spring Harbor Perspectives in Biology

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

(2018) Jeffrey S. Mugridge et al.   Nature Communications

Context-dependent deposition and regulation of mRNAs in P-bodies

(2018) Congwei Wang et al.   eLife

The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock

(2018) Elena Garre et al.   PLoS Genetics

Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

(2018) Jacob W Freimer et al.   eLife

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The IκB kinase complex is a regulator of mRNA stability

(2018) Nadine Mikuda et al.   EMBO JOURNAL

Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus

(2018) Marco Gaviraghi et al.   EMBO JOURNAL

Nonsense-mediated RNA decay in the brain: emerging modulator of neural development and disease

(2018) Samie R. Jaffrey et al.   NATURE REVIEWS NEUROSCIENCE

Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

(2018) Jeffrey S. Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

mRNA decapping: finding the right structures

(2018) Clément Charenton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Conserved mRNA-granule component Scd6 targets Dhh1 to repress translation initiation and activates Dcp2-mediated mRNA decay in vivo

(2018) Quira Zeidan et al.   PLoS Genetics

The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds

(2018) Susanne Kramer et al.   Wiley Interdisciplinary Reviews-RNA

General decapping activators target different subsets of inefficiently translated mRNAs

(2018) Feng He et al.   eLife

Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish

(2017) Yuichiro Mishima et al.   GENES TO CELLS

Characterization of the African Swine Fever Virus Decapping Enzyme during Infection

(2017) Ana Quintas et al.   JOURNAL OF VIROLOGY

LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons

(2017) Jongbo Lee et al.   MOLECULAR CELL

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition

(2017) Boxuan Simen Zhao et al.   NATURE

Codon optimality, bias and usage in translation and mRNA decay

(2017) Gavin Hanson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping

(2017) Stefan Schütz et al.   NUCLEIC ACIDS RESEARCH

Numerous interactions act redundantly to assemble a tunable size of P bodies inSaccharomyces cerevisiae

(2017) Bhalchandra S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5′–3′ mRNA exonuclease in yeast

(2017) Clément Charenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

(2017) Jan Philip Wurm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cap-binding protein 4EHP effects translation silencing by microRNAs

(2017) Clément Chapat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolution of function within the Nudix homology clan

(2017) John R. Srouji et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease

(2017) Rached Alkallas et al.   Nature Communications

Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

(2017) Caroline Vindry et al.   Cell Reports

The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes

(2017) Susanne Kramer   PLoS Pathogens

ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

(2017) Miranda Wang et al.   eLife

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

(2016) Aditya Radhakrishnan et al.   CELL

Droplet organelles?

(2016) Edward M Courchaine et al.   EMBO JOURNAL

K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

(2016) Ulas Tenekeci et al.   MOLECULAR CELL

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator

(2016) Clément Charenton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

(2016) Eugene Valkov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The DDX6–4E-T interaction mediates translational repression and P-body assembly

(2016) Anastasiia Kamenska et al.   NUCLEIC ACIDS RESEARCH

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Nudt3 is an mRNA decapping enzyme that modulates cell migration

(2016) Ewa Grudzien-Nogalska et al.   RNA

TheS. pombemRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface

(2016) Jan Philip Wurm et al.   RNA

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator

(2016) Clément Charenton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

(2016) Eugene Valkov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATPase activity of the DEAD-box protein Dhh1 controls processing body formation

(2016) Christopher Frederick Mugler et al.   eLife

Poxvirus Decapping Enzymes Enhance Virulence by Preventing the Accumulation of dsRNA and the Induction of Innate Antiviral Responses

(2015) Shin-Wu Liu et al.   Cell Host & Microbe

Cellular 5′-3′ mRNA Exonuclease Xrn1 Controls Double-Stranded RNA Accumulation and Anti-Viral Responses

(2015) Hannah M. Burgess et al.   Cell Host & Microbe

Competition between Decapping Complex Formation and Ubiquitin-Mediated Proteasomal Degradation Controls Human Dcp2 Decapping Activity

(2015) Stacy L. Erickson et al.   MOLECULAR AND CELLULAR BIOLOGY

P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexes

(2015) Jessica Ayache et al.   MOLECULAR BIOLOGY OF THE CELL

Discovery of m7G-cap in eukaryotic mRNAs

(2015) Yasuhiro FURUICHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Control of mRNA decapping by positive and negative regulatory elements in the Dcp2 C-terminal domain

(2015) Feng He et al.   RNA

Emerging roles for RNA degradation in viral replication and antiviral defense

(2015) Emma Abernathy et al.   VIROLOGY

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

(2015) Sevim Ozgur et al.   Cell Reports

The eIF4E-Binding Protein 4E-T Is a Component of the mRNA Decay Machinery that Bridges the 5′ and 3′ Termini of Target mRNAs

(2015) Tamiko Nishimura et al.   Cell Reports

The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6

(2015) Eri Seto et al.   PLoS One

In Vitro Reconstitution of a Cellular Phase-Transition Process that Involves the mRNA Decapping Machinery

(2014) Simon A. Fromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Yeast Edc3 Targets RPS28B mRNA for Decapping by Binding to a 3' Untranslated Region Decay-Inducing Regulatory Element

(2014) F. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS

(2014) Valerio Taverniti et al.   NUCLEIC ACIDS RESEARCH

The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1

(2014) Chung-Te Chang et al.   NUCLEIC ACIDS RESEARCH

The C-Terminal Domain from S. cerevisiae Pat1 Displays Two Conserved Regions Involved in Decapping Factor Recruitment

(2014) Zaineb Fourati et al.   PLoS One

Diverse Functions of mRNA Metabolism Factors in Stress Defense and Aging of Caenorhabditis elegans

(2014) Aris Rousakis et al.   PLoS One

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

(2014) Christopher Rouya et al.   RNA

DDX6 and its orthologs as modulators of cellular and viral RNA expression

(2014) Dirk H. Ostareck et al.   Wiley Interdisciplinary Reviews-RNA

Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation

(2013) Donghui Wu et al.   CELL RESEARCH

A genome-wide RNAi screen reveals that mRNA decapping restricts bunyaviral replication by limiting the pools of Dcp2-accessible targets for cap-snatching

(2013) K. C. Hopkins et al.   GENES & DEVELOPMENT

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Pdc1 Functions in the Assembly of P Bodies in Schizosaccharomyces pombe

(2013) Chun-Yu Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

(2013) Xinfu Jiao et al.   MOLECULAR CELL

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing

(2013) A. Kamenska et al.   NUCLEIC ACIDS RESEARCH

Identification of the Rps28 binding motif from yeast Edc3 involved in the autoregulatory feedback loop controlling RPS28B mRNA decay

(2013) Olga Kolesnikova et al.   NUCLEIC ACIDS RESEARCH

Structural analysis of the yeast Dhh1–Pat1 complex reveals how Dhh1 engages Pat1, Edc3 and RNA in mutually exclusive interactions

(2013) Humayun Sharif et al.   NUCLEIC ACIDS RESEARCH

Investigating the Consequences of eIF4E2 (4EHP) Interaction with 4E-Transporter on Its Cellular Distribution in HeLa Cells

(2013) Dorota Kubacka et al.   PLoS One

Multiple Nudix family proteins possess mRNA decapping activity

(2013) M.-G. Song et al.   RNA

Active Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2

(2013) Robin A. Aglietti et al.   STRUCTURE

Architecture of the Lsm1-7-Pat1 Complex: A Conserved Assembly in Eukaryotic mRNA Turnover

(2013) Humayun Sharif et al.   Cell Reports

Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells

(2012) A. T. Neff et al.   GENOME RESEARCH

Human Pumilio Proteins Recruit Multiple Deadenylases to Efficiently Repress Messenger RNAs

(2012) Jamie Van Etten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins

(2012) Purusharth Rajyaguru et al.   MOLECULAR CELL

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5′-3′ exoribonuclease activity

(2012) Jeong Ho Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

(2012) Joerg E Braun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMG5–PNRC2 is functionally dominant compared with SMG5–SMG7 in mammalian nonsense-mediated mRNA decay

(2012) Hana Cho et al.   NUCLEIC ACIDS RESEARCH

Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan

(2012) S. N. Floor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PRMT1 is required for RAP55 to localize to processing bodies

(2012) Ken Matsumoto et al.   RNA Biology

Structural Basis of the PNRC2-Mediated Link between mRNA Surveillance and Decapping

(2012) Tingfeng Lai et al.   STRUCTURE

The ATP-grasp enzymes

(2011) Maria V. Fawaz et al.   BIOORGANIC CHEMISTRY

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

(2011) Simon A Fromm et al.   EMBO JOURNAL

CUP promotes deadenylation and inhibits decapping of mRNA targets

(2011) C. Igreja et al.   GENES & DEVELOPMENT

Intermolecular Interactions within the Abundant DEAD-box Protein Dhh1 Regulate Its Activityin Vivo

(2011) Arnob Dutta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of endonuclease-mediated mRNA decay

(2011) Daniel R. Schoenberg   Wiley Interdisciplinary Reviews-RNA

The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa

(2010) Joerg E Braun et al.   EMBO JOURNAL

HPat provides a link between deadenylation and decapping in metazoa

(2010) Gabrielle Haas et al.   JOURNAL OF CELL BIOLOGY

DDX6 (Rck/p54) Is Required for Efficient Hepatitis C Virus Replication but Not for Internal Ribosome Entry Site-Directed Translation

(2010) R. K. Jangra et al.   JOURNAL OF VIROLOGY

Identification and Analysis of the Interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae

(2010) Y. Harigaya et al.   MOLECULAR AND CELLULAR BIOLOGY

Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

(2010) S. Ozgur et al.   MOLECULAR AND CELLULAR BIOLOGY

Multiple mRNA Decapping Enzymes in Mammalian Cells

(2010) Man-Gen Song et al.   MOLECULAR CELL

Decapping Activators in Saccharomyces cerevisiae Act by Multiple Mechanisms

(2010) Tracy Nissan et al.   MOLECULAR CELL

Identification of a quality-control mechanism for mRNA 5′-end capping

(2010) Xinfu Jiao et al.   NATURE

A split active site couples cap recognition by Dcp2 to activation

(2010) Stephen N Floor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Distinct functions of maternal and somatic Pat1 protein paralogs

(2010) A. Marnef et al.   RNA

Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition

(2010) M. S. Borja et al.   RNA

Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

(2010) Shuyun Dong et al.   PLOS BIOLOGY

Regulation of mRNA decapping

(2010) You Li et al.   Wiley Interdisciplinary Reviews-RNA

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

(2009) Hana Cho et al.   MOLECULAR CELL

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

(2009) Felix Tritschler et al.   MOLECULAR CELL

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa

(2009) F. Tritschler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila processing bodies in oogenesis

(2008) Ming-Der Lin et al.   DEVELOPMENTAL BIOLOGY

RAP55: Insights into an evolutionarily conserved protein family

(2008) Aline Marnef et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) duringCaenorhabditis elegansoogenesis

(2008) Peter R. Boag et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of Human Edc3 and Its Functional Implications

(2008) S. H. M. Ling et al.   MOLECULAR AND CELLULAR BIOLOGY

Similar Modes of Interaction Enable Trailer Hitch and EDC3 To Associate with DCP1 and Me31B in Distinct Protein Complexes

(2008) F. Tritschler et al.   MOLECULAR AND CELLULAR BIOLOGY

mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2

(2008) Mandar V. Deshmukh et al.   MOLECULAR CELL

Structural Basis of Dcp2 Recognition and Activation by Dcp1

(2008) Meipei She et al.   MOLECULAR CELL

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

(2008) L. Decourty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

(2008) M. Jinek et al.   RNA