It’s Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation

(2021) Fabian Morales-Polanco et al.   iScience

Phase separation of Axin organizes the β-catenin destruction complex

(2021) Junxiu Nong et al.   JOURNAL OF CELL BIOLOGY

Local translation in nuclear condensate amyloid bodies

(2021) Phaedra R. Theodoridis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C. elegans germ granules require both assembly and localized regulators for mRNA repression

(2021) Scott Takeo Aoki et al.   Nature Communications

Germline inherited small RNAs facilitate the clearance of untranslated maternal mRNAs in C. elegans embryos

(2021) Piergiuseppe Quarato et al.   Nature Communications

Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility

(2021) Isabella Aprea et al.   PLoS Genetics

In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates

(2021) Weirui Ma et al.   eLife

p53 mediates target gene association with nuclear speckles for amplified RNA expression

(2021) Katherine A. Alexander et al.   MOLECULAR CELL

Imaging translation dynamics in live embryos reveals spatial heterogeneities

(2021) Jeremy Dufourt et al.   SCIENCE

DMA-tudor interaction modules control the specificity of in vivo condensates

(2021) Edward M. Courchaine et al.   CELL

Condensation of pericentrin proteins in human cells illuminates phase separation in centrosome assembly

(2021) Xueer Jiang et al.   JOURNAL OF CELL SCIENCE

Regulation of biomolecular condensates by interfacial protein clusters

(2021) Andrew W. Folkmann et al.   SCIENCE

Are stress granules the RNA analogs of misfolded protein aggregates?

(2021) Nina Ripin et al.   RNA

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

(2020) Chih-Yung S Lee et al.   eLife

The Dynamics of P Granule Liquid Droplets Are Regulated by the Caenorhabditiselegans Germline RNA Helicase GLH-1 via Its ATP Hydrolysis Cycle

(2020) Wenjun Chen et al.   GENETICS

RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia

(2020) Gregory G Fuller et al.   eLife

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans

(2020) Kevin I Manage et al.   eLife

mRNA localization is linked to translation regulation in the Caenorhabditis elegans germ lineage

(2020) Dylan M. Parker et al.   DEVELOPMENT

A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting

(2020) Racha Chouaib et al.   DEVELOPMENTAL CELL

mRNA localization mediates maturation of cytoplasmic cilia in Drosophila spermatogenesis

(2020) Jaclyn M. Fingerhut et al.   JOURNAL OF CELL BIOLOGY

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly

(2020) Nikita Fernandes et al.   NUCLEIC ACIDS RESEARCH

Methods to Study Phase-Separated Condensates and the Underlying Molecular Interactions

(2020) Laura R. Ganser et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mutator Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in Caenorhabditis elegans

(2020) Celja J. Uebel et al.   G3-Genes Genomes Genetics

Mammalian stress granules and P bodies at a glance

(2020) Claire L. Riggs et al.   JOURNAL OF CELL SCIENCE

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

(2020) Kin Man Suen et al.   Nature Communications

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

Splicing at the phase-separated nuclear speckle interface: a model

(2020) Susan E Liao et al.   NUCLEIC ACIDS RESEARCH

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

(2020) Chanjae Lee et al.   eLife

Multicolour single-molecule tracking of mRNA interactions with RNP granules

(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth

(2019) Mariavittoria Pizzinga et al.   JOURNAL OF CELL BIOLOGY

Developmental Control of the Cell Cycle: Insights from Caenorhabditis elegans

(2019) Edward T. Kipreos et al.   GENETICS

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality

(2019) Sethuramasundaram Pitchiaya et al.   MOLECULAR CELL

Rare De Novo Missense Variants in RNA Helicase DDX6 Cause Intellectual Disability and Dysmorphic Features and Lead to P-Body Defects and RNA Dysregulation

(2019) Chris Balak et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Germ Granules Coordinate RNA-Based Epigenetic Inheritance Pathways

(2019) Anne E. Dodson et al.   DEVELOPMENTAL CELL

P Granules Protect RNA Interference Genes from Silencing by piRNAs

(2019) John Paul T. Ouyang et al.   DEVELOPMENTAL CELL

Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus

(2019) Run-Wen Yao et al.   MOLECULAR CELL

DEAD-box ATPases are global regulators of phase-separated organelles

(2019) Maria Hondele et al.   NATURE

Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity

(2019) Xiao Yu et al.   Cell Reports

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

(2019) David T. McSwiggen et al.   GENES & DEVELOPMENT

Properties of Stress Granule and P-Body Proteomes

(2019) Ji-Young Youn et al.   MOLECULAR CELL

Protein components of ribonucleoprotein granules from Drosophila germ cells oligomerize and show distinct spatial organization during germline development

(2019) Hieu D. L. Vo et al.   Scientific Reports

Identification of piRNA Binding Sites Reveals the Argonaute Regulatory Landscape of the C. elegans Germline

(2018) En-Zhi Shen et al.   CELL

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

(2018) Ke Zhang et al.   CELL

Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules

(2018) Matthew G. Niepielko et al.   CURRENT BIOLOGY

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

(2018) Donglei Zhang et al.   SCIENCE

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

(2018) Guadalupe Sepulveda et al.   eLife

Context-dependent deposition and regulation of mRNAs in P-bodies

(2018) Congwei Wang et al.   eLife

The P Granules of C. elegans: A Genetic Model for the Study of RNA–Protein Condensates

(2018) Geraldine Seydoux   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance

(2018) Gang Wan et al.   NATURE

Phase transitioned nuclear Oskar promotes cell division of Drosophila primordial germ cells

(2018) Kathryn E Kistler et al.   eLife

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

Functional equivalence of germ plasm organizers

(2018) Pritesh Krishnakumar et al.   PLoS Genetics

A liquid-like organelle at the root of motile ciliopathy

(2018) Ryan L Huizar et al.   eLife

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Numerous interactions act redundantly to assemble a tunable size of P bodies inSaccharomyces cerevisiae

(2017) Bhalchandra S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent evolution of germ granule nucleators: A hypothesis

(2017) Arpita Kulkarni et al.   Stem Cell Research

piRNA Biogenesis in Drosophila melanogaster

(2017) Xiawei Huang et al.   TRENDS IN GENETICS

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress

(2017) Meiyan Jin et al.   Cell Reports

An Overview of Pickering Emulsions: Solid-Particle Materials, Classification, Morphology, and Applications

(2017) Yunqi Yang et al.   Frontiers in Pharmacology

Germ granule-mediated RNA regulation in male germ cells

(2017) Tiina Lehtiniemi et al.   REPRODUCTION

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Novel mutants of theauberginegene

(2016) H. Bahar Sahin et al.   FLY

Reduced stress granule formation and cell death in fibroblasts with the A382T mutation of TARDBP gene: evidence for loss of TDP-43 nuclear function

(2016) Sandro Orrù et al.   HUMAN MOLECULAR GENETICS

Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm

(2016) Anastassios Vourekas et al.   NATURE

A human microprotein that interacts with the mRNA decapping complex

(2016) Nadia G D'Lima et al.   Nature Chemical Biology

XenopusPiwi proteins interact with a broad proportion of the oocyte transcriptome

(2016) James A. Toombs et al.   RNA

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans

(2016) Gabriela Huelgas-Morales et al.   G3-Genes Genomes Genetics

Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3

(2016) Jarrett Smith et al.   eLife

Electrostatic Localization of RNA to Protocell Membranes by Cationic Hydrophobic Peptides

(2015) Neha P. Kamat et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles

(2015) Timothy J. Nott et al.   MOLECULAR CELL

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

(2015) Katy N. Olafson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated assembly of a supramolecular centrosome scaffold in vitro

(2015) J. B. Woodruff et al.   SCIENCE

Drosophila germ granules are structured and contain homotypic mRNA clusters

(2015) Tatjana Trcek et al.   Nature Communications

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage

(2014) Adva Aizer et al.   JOURNAL OF CELL SCIENCE

Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer

(2014) Tamar Hashimshony et al.   NATURE

Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts

(2014) Xiaoxue Yang et al.   PLoS Genetics

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

Translation Repressors, an RNA Helicase, and Developmental Cues Control RNP Phase Transitions during Early Development

(2013) Arnaud Hubstenberger et al.   DEVELOPMENTAL CELL

RNA Seeds Higher-Order Assembly of FUS Protein

(2013) Jacob C. Schwartz et al.   Cell Reports

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

(2012) Tina W. Han et al.   CELL

Stress Granules Inhibit Apoptosis by Reducing Reactive Oxygen Species Production

(2012) M. Takahashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Translation-Independent Localization of mRNA in E. coli

(2011) K. Nevo-Dinur et al.   SCIENCE

RNA Granules in Germ Cells

(2011) E. Voronina et al.   Cold Spring Harbor Perspectives in Biology

Cytoplasmic Partitioning of P Granule Components Is Not Required to Specify the Germline in C. elegans

(2010) C. M. Gallo et al.   SCIENCE

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

(2009) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

A C. elegans Piwi, PRG-1, Regulates 21U-RNAs during Spermatogenesis

(2008) Guilin Wang et al.   CURRENT BIOLOGY

Temporal and Spatial Control of Germ-Plasm RNAs

(2008) Prashanth Rangan et al.   CURRENT BIOLOGY

Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells

(2008) S. Jadhav et al.   DEVELOPMENT

Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos

(2008) Christopher M. Gallo et al.   DEVELOPMENTAL BIOLOGY

Genetic Analysis of the Caenorhabditis elegans GLH Family of P-Granule Proteins

(2008) C. Spike et al.   GENETICS

Stress induces the assembly of RNA granules in the chloroplast ofChlamydomonas reinhardtii

(2008) James Uniacke et al.   JOURNAL OF CELL BIOLOGY

PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegans

(2008) Pedro J. Batista et al.   MOLECULAR CELL

Codependent Functions of RSK2 and the Apoptosis-Promoting Factor TIA-1 in Stress Granule Assembly and Cell Survival

(2008) T.S. Karin Eisinger-Mathason et al.   MOLECULAR CELL