FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function

The molecular biology of FMRP: new insights into fragile X syndrome

(2021) Joel D. Richter et al.   NATURE REVIEWS NEUROSCIENCE

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice

(2021) Marta Prieto et al.   Nature Communications

RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein

(2020) Youssi M. Athar et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of RNA granules by FMRP and implications for neurological diseases

(2020) Austin Lai et al.   TRAFFIC

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

(2019) Jeshlee Vijayakumar et al.   Nature Communications

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

(2019) Tae Hun Kim et al.   SCIENCE

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

(2018) Anwesha Banerjee et al.   BRAIN RESEARCH

Modeling Fragile X Syndrome in Drosophila

(2018) Małgorzata Drozd et al.   Frontiers in Molecular Neuroscience

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Multiple Modes of Protein–Protein Interactions Promote RNP Granule Assembly

(2018) Tanja Mittag et al.   JOURNAL OF MOLECULAR BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons

(2017) Pallavi P. Gopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Multifarious Functions of the Fragile X Mental Retardation Protein

(2017) Jenna K. Davis et al.   TRENDS IN GENETICS

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules

(2016) Rachid El Fatimy et al.   PLoS Genetics

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Independent role for presynaptic FMRP revealed by anFMR1missense mutation associated with intellectual disability and seizures

(2015) Leila K. Myrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile X syndrome due to a missense mutation

(2014) Leila K Myrick et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain

(2014) Leila K. Myrick et al.   HUMAN MOLECULAR GENETICS

Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences

(2014) Joshua A. Suhl et al.   HUMAN MOLECULAR GENETICS

Fragile X Mental Retardation Protein Regulates Translation by Binding Directly to the Ribosome

(2014) Eileen Chen et al.   MOLECULAR CELL

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

FISH-quant: automatic counting of transcripts in 3D FISH images

(2013) Florian Mueller et al.   NATURE METHODS

Characterization of Fragile X Mental Retardation Protein Recruitment and Dynamics in Drosophila Stress Granules

(2013) Cristina Gareau et al.   PLoS One

The miRNA Pathway Controls Rapid Changes in Activity-Dependent Synaptic Structure at the Drosophila melanogaster Neuromuscular Junction

(2013) Katherine R. Nesler et al.   PLoS One

FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control

(2013) I. P. Sudhakaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA Seeds Higher-Order Assembly of FUS Protein

(2013) Jacob C. Schwartz et al.   Cell Reports

The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction

(2012) S. J. Pradhan et al.   JOURNAL OF CELL SCIENCE

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

FMRP targets distinct mRNA sequence elements to regulate protein expression

(2012) Manuel Ascano et al.   NATURE

Characterization of Fragile X Mental Retardation Protein granules formation and dynamics in Drosophila

(2012) C. Gareau et al.   Biology Open

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

(2011) Jennifer C. Darnell et al.   CELL

Neuronal RNA granule contains ApCPEB1, a novel cytoplasmic polyadenylation element binding protein, in Aplysia sensory neuron

(2010) Yeon-Su Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs

(2009) J. C. Darnell et al.   HUMAN MOLECULAR GENETICS

A Mouse Model of the Human Fragile X Syndrome I304N Mutation

(2009) Julie B. Zang et al.   PLoS Genetics

A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

(2008) Jason B. Dictenberg et al.   DEVELOPMENTAL CELL

Dendrites of Mammalian Neurons Contain Specialized P-Body-Like Structures That Respond to Neuronal Activation

(2008) N. Cougot et al.   JOURNAL OF NEUROSCIENCE

Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons

(2008) Patricia S. Estes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE