A working model for condensate RNA-binding proteins as matchmakers for protein complex assembly

Core Fermentation (CoFe) granules focus coordinated glycolytic mRNA localization and translation to fuel glucose fermentation

(2021) Fabian Morales-Polanco et al.   iScience

In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates

(2021) Weirui Ma et al.   eLife

Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

(2021) Rohini R Nair et al.   eLife

RNAs as Regulators of Cellular Matchmaking

(2021) Nikita Fernandes et al.   Frontiers in Molecular Biosciences

DMA-tudor interaction modules control the specificity of in vivo condensates

(2021) Edward M. Courchaine et al.   CELL

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

(2021) William Peeples et al.   Nature Chemical Biology

L-bodies are RNA–protein condensates driving RNA localization in Xenopus oocytes

(2021) Christopher R. Neil et al.   MOLECULAR BIOLOGY OF THE CELL

Monosomes actively translate synaptic mRNAs in neuronal processes

(2020) Anne Biever et al.   SCIENCE

Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

(2020) Matthew R. King et al.   Nature Communications

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

(2020) Jean A. Smith et al.   JOURNAL OF CELL BIOLOGY

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Local Translation in Growth Cones and Presynapses, Two Axonal Compartments for Local Neuronal Functions

(2020) Yukio Sasaki   Biomolecules

A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting

(2020) Racha Chouaib et al.   DEVELOPMENTAL CELL

RPS28B mRNA acts as a scaffold promoting cis-translational interaction of proteins driving P-body assembly

(2020) Nikita Fernandes et al.   NUCLEIC ACIDS RESEARCH

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA matchmaking in chromatin regulation

(2020) Stephen K. Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions

(2020) Maiwen Caudron-Herger et al.   NUCLEIC ACIDS RESEARCH

Co-translational assembly of proteasome subunits in NOT1-containing assemblysomes

(2019) Olesya O. Panasenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

(2019) Chee-Huat Linus Eng et al.   NATURE

Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth

(2019) Mariavittoria Pizzinga et al.   JOURNAL OF CELL BIOLOGY

Gain of Additional BIRC3 Protein Functions through 3ʹ-UTR-Mediated Protein Complex Formation

(2019) Shih-Han Lee et al.   MOLECULAR CELL

R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation

(2019) Maiwen Caudron-Herger et al.   MOLECULAR CELL

Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments

(2019) Anne-Sophie Hafner et al.   SCIENCE

Co-translational assembly of mammalian nuclear multisubunit complexes

(2019) Ivanka Kamenova et al.   Nature Communications

RNA proximity sequencing reveals the spatial organization of the transcriptome in the nucleus

(2019) Jörg Morf et al.   NATURE BIOTECHNOLOGY

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

(2019) Xin Chen et al.   NATURE CELL BIOLOGY

Local translation in neurons: visualization and function

(2019) Christine E. Holt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer

(2019) Mingxia Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Peptide Channeling: The Key to MHC Class I Immunosurveillance?

(2019) Jonathan W. Yewdell et al.   TRENDS IN CELL BIOLOGY

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Advances in CLIP Technologies for Studies of Protein-RNA Interactions

(2018) Flora C.Y. Lee et al.   MOLECULAR CELL

mRNA structure determines specificity of a polyQ-driven phase separation

(2018) Erin M. Langdon et al.   SCIENCE

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

(2018) Elke F. Roovers et al.   DEVELOPMENTAL CELL

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling

(2018) Ayala Shiber et al.   NATURE

Protein complexes assemble as they are being made

(2018) Christine Mayr   NATURE

A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

(2018) Weirui Ma et al.   CELL

Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics

(2018) Mario Hofweber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribosome assembly coming into focus

(2018) Sebastian Klinge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

(2018) Marta Pabis et al.   NUCLEIC ACIDS RESEARCH

C-terminal motifs in promyelocytic leukemia protein isoforms critically regulate PML nuclear body formation

(2017) Chuang Li et al.   JOURNAL OF CELL SCIENCE

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Single-Molecule Quantification of Translation-Dependent Association of mRNAs with the Endoplasmic Reticulum

(2017) Franka Voigt et al.   Cell Reports

Dynamics of Translation of Single mRNA Molecules In Vivo

(2016) Xiaowei Yan et al.   CELL

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes

(2016) Kristopher W. Brannan et al.   MOLECULAR CELL

Cotranslational signal-independent SRP preloading during membrane targeting

(2016) Justin W. Chartron et al.   NATURE

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology

(2015) Janosch Hennig et al.   BIOESSAYS

Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth

(2015) Francesca Moretti et al.   MOLECULAR AND CELLULAR BIOLOGY

ELAV Links Paused Pol II to Alternative Polyadenylation in the Drosophila Nervous System

(2015) Katarzyna Oktaba et al.   MOLECULAR CELL

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Alternative 3′ UTRs act as scaffolds to regulate membrane protein localization

(2015) Binyamin D. Berkovits et al.   NATURE

Operon structure and cotranslational subunit association direct protein assembly in bacteria

(2015) Y.-W. Shieh et al.   SCIENCE

Spatially resolved, highly multiplexed RNA profiling in single cells

(2015) K. H. Chen et al.   SCIENCE

MOV10 Is a 5′ to 3′ RNA Helicase Contributing to UPF1 mRNA Target Degradation by Translocation along 3′ UTRs

(2014) Lea H. Gregersen et al.   MOLECULAR CELL

Structural basis for the assembly of the Sxl–Unr translation regulatory complex

(2014) Janosch Hennig et al.   NATURE

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

In the right place at the right time: visualizing and understanding mRNA localization

(2014) Adina R. Buxbaum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Granules Harboring Translationally Active mRNAs Provide a Platform for P-Body Formation following Stress

(2014) Jennifer Lui et al.   Cell Reports

Proteome-Wide Characterization of the RNA-Binding Protein RALY-Interactome Using the in Vivo-Biotinylation-Pulldown-Quant (iBioPQ) Approach

(2013) Stefan Tenzer et al.   JOURNAL OF PROTEOME RESEARCH

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-binding proteins and translational regulation in axons and growth cones

(2013) Hanna Hörnberg et al.   Frontiers in Neuroscience

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

The p38/MK2-Driven Exchange between Tristetraprolin and HuR Regulates AU–Rich Element–Dependent Translation

(2012) Christopher Tiedje et al.   PLoS Genetics

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins

(2011) Konstantinos Tripsianes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA targets of wild-type and mutant FET family proteins

(2011) Jessica I Hoell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

(2011) Weijun Dai et al.   NUCLEIC ACIDS RESEARCH

Localization of mRNAs coding for mitochondrial proteins in the yeast Saccharomyces cerevisiae

(2011) N. Gadir et al.   RNA

A proteomic study of TAR-RNA binding protein (TRBP)-associated factors

(2011) Ya-Hui Chi et al.   Cell and Bioscience

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor

(2009) M. Dienstbier et al.   GENES & DEVELOPMENT

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Yeast Mitochondrial Biogenesis: A Role for the PUF RNA-Binding Protein Puf3p in mRNA Localization

(2008) Yann Saint-Georges et al.   PLoS One