Functional organization of RNA polymerase II in nuclear subcompartments

Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice

(2021) Nils Schneider et al.   Science Advances

Physical mechanisms of chromatin spatial organization

(2021) Andrea M. Chiariello et al.   FEBS Journal

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

(2021) David A. Garcia et al.   MOLECULAR CELL

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

(2021) Prashant Rawat et al.   MOLECULAR CELL

Transcription organizes euchromatin via microphase separation

(2021) Lennart Hilbert et al.   Nature Communications

The role of liquid–liquid phase separation in regulating enzyme activity

(2021) Brian G. O'Flynn et al.   CURRENT OPINION IN CELL BIOLOGY

Towards a ‘Spot On’ Understanding of Transcription in the Nucleus

(2021) Simona Patange et al.   JOURNAL OF MOLECULAR BIOLOGY

Is transcriptional regulation just going through a phase?

(2021) Geeta J. Narlikar et al.   MOLECULAR CELL

The Pol II preinitiation complex (PIC) influences Mediator binding but not promoter–enhancer looping

(2021) Fei Sun et al.   GENES & DEVELOPMENT

Nuclear compartmentalization as a mechanism of quantitative control of gene expression

(2021) Prashant Bhat et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation?

(2021) Karsten Rippe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Everything at once: cryo-EM yields remarkable insights into human RNA polymerase II transcription

(2021) Allison C. Schier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Liquid–Liquid Phase Separation in Chromatin

(2021) Karsten Rippe   Cold Spring Harbor Perspectives in Biology

Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads

(2021) Anastasia C. Murthy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A ubiquitous disordered protein interaction module orchestrates transcription elongation

(2021) Katerina Cermakova et al.   SCIENCE

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Phase separation provides a mechanism to reduce noise in cells

(2020) A. Klosin et al.   SCIENCE

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

(2020) Yi Lu et al.   NATURE CELL BIOLOGY

Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus

(2020) Andreas Maiser et al.   Scientific Reports

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

(2020) Mian Wei et al.   Science Advances

RNA Pol II Length and Disorder Enable Cooperative Scaling of Transcriptional Bursting

(2020) Porfirio Quintero-Cadena et al.   MOLECULAR CELL

Intrinsically Disordered Regions Direct Transcription Factor In Vivo Binding Specificity

(2020) Sagie Brodsky et al.   MOLECULAR CELL

Mechanistic modeling of chromatin folding to understand function

(2020) Chris A. Brackey et al.   NATURE METHODS

Disordered proteins follow diverse transition paths as they fold and bind to a partner

(2020) Jae-Yeol Kim et al.   SCIENCE

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dissection of c-AMP Response Element Architecture by Using Genomic and Episomal Massively Parallel Reporter Assays

(2020) Jessica E. Davis et al.   Cell Systems

The Self-Organizing Genome: Principles of Genome Architecture and Function

(2020) Tom Misteli   CELL

Nucleated transcriptional condensates amplify gene expression

(2020) Ming-Tzo Wei et al.   NATURE CELL BIOLOGY

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-gene imaging links genome topology, promoter–enhancer communication and transcription control

(2020) Jieru Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging

(2020) Samantha Kent et al.   Cell Reports

Transcriptional suppression of ribosomal DNA with phase separation

(2020) Satoru Ide et al.   Science Advances

Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins

(2019) Ibraheem Ali et al.   MOLECULAR CELL

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

(2019) Laila El Khattabi et al.   CELL

Enhancer Features that Drive Formation of Transcriptional Condensates

(2019) Krishna Shrinivas et al.   MOLECULAR CELL

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

(2019) Yang Eric Guo et al.   NATURE

Organization and regulation of gene transcription

(2019) Patrick Cramer   NATURE

Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

(2019) Carl G. de Boer et al.   NATURE BIOTECHNOLOGY

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

RNA polymerase II clustering through carboxy-terminal domain phase separation

(2018) Marc Boehning et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations

(2018) Peter R Cook et al.   NUCLEIC ACIDS RESEARCH

Transcription-Dependent Formation of Nuclear Granules Containing FUS and RNA Pol II

(2018) Valery F. Thompson et al.   BIOCHEMISTRY

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

(2018) Yongdae Shin et al.   CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

(2017) Anders S Hansen et al.   eLife

Study of RNA Polymerase II Clustering inside Live-Cell Nuclei Using Bayesian Nanoscopy

(2016) Xuanze Chen et al.   ACS Nano

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments

(2015) Thomas Cremer et al.   FEBS LETTERS

Evolution of disorder in Mediator complex and its functional relevance

(2015) Malini Nagulapalli et al.   NUCLEIC ACIDS RESEARCH

Dissecting the nascent human transcriptome by analysing the RNA content of transcription factories

(2015) Maïwen Caudron-Herger et al.   NUCLEIC ACIDS RESEARCH

Transcription Factories: Genome Organization and Gene Regulation

(2013) Argyris Papantonis et al.   CHEMICAL REVIEWS

Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?

(2011) Timothy J. Stasevich et al.   CHROMOSOMA

The proteomes of transcription factories containing RNA polymerases I, II or III

(2011) Svitlana Melnik et al.   NATURE METHODS

Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

(2010) Martijn S. Luijsterburg et al.   JOURNAL OF CELL BIOLOGY

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

Genome organization: Balancing stability and plasticity

(2008) Malte Wachsmuth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH