Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Local translation in nuclear condensate amyloid bodies

(2021) Phaedra R. Theodoridis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of biomolecular condensates by interfacial protein clusters

(2021) Andrew W. Folkmann et al.   SCIENCE

Nucleation landscape of biomolecular condensates

(2021) Shunsuke F. Shimobayashi et al.   NATURE

Regulated changes in material properties underlie centrosome disassembly during mitotic exit

(2020) Matthäus Mittasch et al.   JOURNAL OF CELL BIOLOGY

Phase separation organizes the site of autophagosome formation

(2020) Yuko Fujioka et al.   NATURE

Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation

(2020) Annabelle Dold et al.   PLoS Genetics

Compartmentalized oskar degradation in the germ plasm safeguards germline development

(2020) Catherine E Eichler et al.   eLife

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

Liquid-liquid phase separation drives skin barrier formation

(2020) Felipe Garcia Quiroz et al.   SCIENCE

Mechanisms and Regulation of RNA Condensation in RNP Granule Formation

(2020) Devin Tauber et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamic metastable long-living droplets formed by sticker-spacer proteins

(2020) Srivastav Ranganathan et al.   eLife

A quantitative inventory of yeast P body proteins reveals principles of composition and specificity

(2020) Wenmin Xing et al.   eLife

The nucleolus as a multiphase liquid condensate

(2020) Denis L. J. Lafontaine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein condensates as aging Maxwell fluids

(2020) Louise Jawerth et al.   SCIENCE

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

(2019) Andrea Putnam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

(2019) Simon Alberti et al.   CELL

Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties

(2019) Steven Boeynaems et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo

(2019) Jeshlee Vijayakumar et al.   Nature Communications

Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis

(2019) Bernhard Hampoelz et al.   CELL

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

Quantitative mRNA Imaging with Dual Channel qFIT Probes to Monitor Distribution and Degree of Hybridization

(2018) Imre Gaspar et al.   ACS Chemical Biology

Functional Implications of Intracellular Phase Transitions

(2018) Alex S. Holehouse et al.   BIOCHEMISTRY

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

The prion-like domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization

(2018) Shannon N. Rhoads et al.   MOLECULAR BIOLOGY OF THE CELL

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

(2018) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization and Function of Non-dynamic Biomolecular Condensates

(2018) Jeffrey B. Woodruff et al.   TRENDS IN BIOCHEMICAL SCIENCES

Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly

(2018) David S.W. Protter et al.   Cell Reports

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging

(2017) Wim J.H. Hagen et al.   JOURNAL OF STRUCTURAL BIOLOGY

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enzymatic production of single-molecule FISH and RNA capture probes

(2017) Imre Gaspar et al.   RNA

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

(2017) Amayra Hernández-Vega et al.   Cell Reports

Amyloid-like Self-Assembly of a Cellular Compartment

(2016) Elvan Boke et al.   CELL

Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism

(2016) Shambaditya Saha et al.   CELL

Adaptation to Stressors by Systemic Protein Amyloidogenesis

(2016) Timothy E. Audas et al.   DEVELOPMENTAL CELL

Long Oskar Controls Mitochondrial Inheritance in Drosophila melanogaster

(2016) Thomas Ryan Hurd et al.   DEVELOPMENTAL CELL

An RNA‐binding atypical tropomyosin recruits kinesin‐1 dynamically to oskar mRNPs

(2016) Imre Gáspár et al.   EMBO JOURNAL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II

(2015) Kathleen A. Burke et al.   MOLECULAR CELL

Independent and coordinate trafficking of single Drosophila germ plasm mRNAs

(2015) Shawn C. Little et al.   NATURE CELL BIOLOGY

Region-Specific Activation of oskar mRNA Translation by Inhibition of Bruno-Mediated Repression

(2015) Goheun Kim et al.   PLoS Genetics

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

(2015) Hermann Broder Schmidt et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

(2014) A. K. Lancaster et al.   BIOINFORMATICS

Klar ensures thermal robustness ofoskarlocalization by restraining RNP motility

(2014) Imre Gaspar et al.   JOURNAL OF CELL BIOLOGY

In the right place at the right time: visualizing and understanding mRNA localization

(2014) Adina R. Buxbaum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Volta potential phase plate for in-focus phase contrast transmission electron microscopy

(2014) R. Danev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A stem-loop structure directs oskar mRNA to microtubule minus ends

(2014) H. Jambor et al.   RNA

Dual Specificity Kinase DYRK3 Couples Stress Granule Condensation/Dissolution to mTORC1 Signaling

(2013) Frank Wippich et al.   CELL

Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

(2013) Scott J. Gratz et al.   GENETICS

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct domains of Bruno bind specifically to theoskarmRNA

(2011) Mark Snee et al.   RNA Biology

Dimerization of oskar 3' UTRs promotes hitchhiking for RNA localization in the Drosophila oocyte

(2011) H. Jambor et al.   RNA

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

mRNA Localization: Gene Expression in the Spatial Dimension

(2009) Kelsey C. Martin et al.   CELL

Lighting up mRNA localization in Drosophila oogenesis

(2009) A. N. Becalska et al.   DEVELOPMENT

Drosophila PTB promotes formation of high-order RNP particles and represses oskar translation

(2009) F. Besse et al.   GENES & DEVELOPMENT

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

In Vivo Imaging of oskar mRNA Transport Reveals the Mechanism of Posterior Localization

(2008) Vitaly L. Zimyanin et al.   CELL

Drosophila processing bodies in oogenesis

(2008) Ming-Der Lin et al.   DEVELOPMENTAL BIOLOGY

Translational control of localized mRNAs: restricting protein synthesis in space and time

(2008) Florence Besse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY