Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

(2022) Haneul Yoo et al.   MOLECULAR CELL

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies

(2022) Giulia Biancon et al.   MOLECULAR CELL

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

(2021) Brian D. Freibaum et al.   JOURNAL OF CELL BIOLOGY

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

(2021) Simon Alberti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stress granule formation, disassembly, and composition are regulated by alphavirus ADP-ribosylhydrolase activity

(2021) Aravinth Kumar Jayabalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Size Matters: An Analysis of Gene Length in the Human Genome

(2021) Inês Lopes et al.   Frontiers in Genetics

Stress granules: regulators or by‐products?

(2021) Daniel Mateju et al.   FEBS Journal

The role of stress-activated RNA-protein granules in surviving adversity

(2021) Leah E. Escalante et al.   RNA

The Integral Role of RNA in Stress Granule Formation and Function

(2021) Danae Campos-Melo et al.   Frontiers in Cell and Developmental Biology

Ubiquitination is essential for recovery of cellular activities after heat shock

(2021) Brian A. Maxwell et al.   SCIENCE

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

(2021) Youngdae Gwon et al.   SCIENCE

Are stress granules the RNA analogs of misfolded protein aggregates?

(2021) Nina Ripin et al.   RNA

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A

(2020) Devin Tauber et al.   CELL

Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production

(2020) Christiane Iserman et al.   CELL

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress

(2020) Syam Prakash Somasekharan et al.   NUCLEIC ACIDS RESEARCH

Mechanisms and Regulation of RNA Condensation in RNP Granule Formation

(2020) Devin Tauber et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coupling of translation quality control and mRNA targeting to stress granules

(2020) Stephanie L. Moon et al.   JOURNAL OF CELL BIOLOGY

The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules

(2020) Jan Keiten-Schmitz et al.   MOLECULAR CELL

An In Vitro Assembly System Identifies Roles for RNA Nucleation and ATP in Yeast Stress Granule Formation

(2020) Kyle Begovich et al.   MOLECULAR CELL

A Ca2+-Dependent Switch Activates Axonal Casein Kinase 2α Translation and Drives G3BP1 Granule Disassembly for Axon Regeneration

(2020) Pabitra K. Sahoo et al.   CURRENT BIOLOGY

Phase separation at the nanoscale quantified by dcFCCS

(2020) Sijia Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

(2020) Nina Eiermann et al.   Viruses-Basel

Molecular mechanisms of stress granule assembly and disassembly

(2020) Sarah Hofmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

(2020) Hagai Marmor-Kollet et al.   MOLECULAR CELL

RNA partitioning into stress granules is based on the summation of multiple interactions

(2020) Tyler Matheny et al.   RNA

Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules

(2019) Nobuyuki Shiina   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Multicolour single-molecule tracking of mRNA interactions with RNP granules

(2019) Stephanie L. Moon et al.   NATURE CELL BIOLOGY

Stress-induced mRNP granules: Form and function of processing bodies and stress granules

(2019) Anna R. Guzikowski et al.   Wiley Interdisciplinary Reviews-RNA

Cellular sensing by phase separation: Using the process, not just the products

(2019) Haneul Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZAP’s stress granule localization is correlated with its antiviral activity and induced by virus replication

(2019) Lok Man John Law et al.   PLoS Pathogens

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

(2019) Peipei Zhang et al.   eLife

Stress granule: a promising target for cancer treatment

(2019) Xiaomeng Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

RNA structure drives interaction with proteins

(2019) Natalia Sanchez de Groot et al.   Nature Communications

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether

(2019) Ya-Cheng Liao et al.   CELL

Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

(2019) Alejandro Padrón et al.   MOLECULAR CELL

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning

(2019) Tyler Matheny et al.   MOLECULAR AND CELLULAR BIOLOGY

The prion-like protein kinase Sky1 is required for efficient stress granule disassembly

(2019) Jenifer E. Shattuck et al.   Nature Communications

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Quality Control of Membraneless Organelles

(2018) Simon Alberti et al.   JOURNAL OF MOLECULAR BIOLOGY

Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS

(2018) Hannah M. Burgess et al.   JOURNAL OF VIROLOGY

Systematic Characterization of Stress-Induced RNA Granulation

(2018) Sim Namkoong et al.   MOLECULAR CELL

High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies

(2018) Ji-Young Youn et al.   MOLECULAR CELL

RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

(2018) Briana Van Treeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

(2018) Sonja Kroschwald et al.   Cell Reports

Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies

(2018) Briana Van Treeck et al.   CELL

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sindbis virus infection causes cell death by nsP2-induced transcriptional shutoff or by nsP3-dependent translational shutoff.

(2018) Ivan Akhrymuk et al.   JOURNAL OF VIROLOGY

Stress Granules and Processing Bodies in Translational Control

(2018) Pavel Ivanov et al.   Cold Spring Harbor Perspectives in Biology

Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration

(2018) Pabitra K. Sahoo et al.   Nature Communications

Differences between acute and chronic stress granules, and how these differences may impact function in human disease

(2018) Lucas C. Reineke et al.   BIOCHEMICAL PHARMACOLOGY

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

(2018) Rachy Abraham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-Body Purification Reveals the Condensation of Repressed mRNA Regulons

(2017) Arnaud Hubstenberger et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

(2017) Ian R. Mackenzie et al.   NEURON

ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics

(2016) Jozsef Gal et al.   ACTA NEUROPATHOLOGICA

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

(2016) Saumya Jain et al.   CELL

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

G3BP–Caprin1–USP10 complexes mediate stress granule condensation and associate with 40S subunits

(2016) Nancy Kedersha et al.   JOURNAL OF CELL BIOLOGY

Disruption of Stress Granule Formation by the Multifunctional Cricket Paralysis Virus 1A Protein

(2016) Anthony Khong et al.   JOURNAL OF VIROLOGY

Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation

(2016) David E. Weinberg et al.   Cell Reports

Distinct stages in stress granule assembly and disassembly

(2016) Joshua R Wheeler et al.   eLife

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Systemic control of protein synthesis through sequestration of translation and ribosome biogenesis factors during severe heat stress

(2015) Valeria Cherkasov et al.   FEBS LETTERS

Pheromone-encoding mRNA is transported to the yeast mating projection by specific RNP granules

(2015) Stella Aronov et al.   JOURNAL OF CELL BIOLOGY

It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles

(2015) Lin Guo et al.   MOLECULAR CELL

Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules

(2015) Sonja Kroschwald et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Promoter sequences direct cytoplasmic localization and translation of mRNAs during starvation in yeast

(2014) Brian M. Zid et al.   NATURE

Stress granules are dispensable for mRNA stabilization during cellular stress

(2014) Nadine Bley et al.   NUCLEIC ACIDS RESEARCH

5-Fluorouracil affects assembly of stress granules based on RNA incorporation

(2014) Christian Kaehler et al.   NUCLEIC ACIDS RESEARCH

Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules

(2014) Ouissame Bounedjah et al.   NUCLEIC ACIDS RESEARCH

Selective mRNA sequestration by OLIGOURIDYLATE-BINDING PROTEIN 1 contributes to translational control during hypoxia inArabidopsis

(2014) Reed Sorenson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts

(2014) Xiaoxue Yang et al.   PLoS Genetics

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Coordination of Translational Control and Protein Homeostasis during Severe Heat Stress

(2013) Valeria Cherkasov et al.   CURRENT BIOLOGY

Phase transitions and size scaling of membrane-less organelles

(2013) Clifford P. Brangwynne   JOURNAL OF CELL BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Heat Shock-Induced Accumulation of Translation Elongation and Termination Factors Precedes Assembly of Stress Granules in S. cerevisiae

(2013) Tomas Grousl et al.   PLoS One

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation

(2012) H. Katoh et al.   JOURNAL OF VIROLOGY

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

(2012) Ken Fujimura et al.   NUCLEIC ACIDS RESEARCH

P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation

(2012) C. J. Decker et al.   Cold Spring Harbor Perspectives in Biology

Reconsidering Movement of Eukaryotic mRNAs between Polysomes and P Bodies

(2011) Joshua A. Arribere et al.   MOLECULAR CELL

The chemotherapeutic agent bortezomib induces the formation of stress granules

(2010) Marie-Josée Fournier et al.   Cancer Cell International

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

(2010) Daryl A. Bosco et al.   HUMAN MOLECULAR GENETICS

Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae

(2010) J. R. Buchan et al.   JOURNAL OF CELL SCIENCE

Microtubules govern stress granule mobility and dynamics

(2009) Elena S. Nadezhdina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RhoA/ROCK1 signaling regulates stress granule formation and apoptosis

(2009) Nien-Pei Tsai et al.   CELLULAR SIGNALLING

Robust heat shock induces eIF2 -phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

(2009) T. Grousl et al.   JOURNAL OF CELL SCIENCE

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Metazoan stress granule assembly is mediated by P-eIF2 -dependent and -independent mechanisms

(2009) N. G. Farny et al.   RNA

P bodies promote stress granule assembly inSaccharomyces cerevisiae

(2008) J. Ross Buchan et al.   JOURNAL OF CELL BIOLOGY

Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2  phosphorylation at Thr169

(2008) S. Kramer et al.   JOURNAL OF CELL SCIENCE

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY