Flavonoids attenuate cancer metabolism by modulating Lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2

Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity

(2022) Nan Shen et al.   FOOD CHEMISTRY

Epigallocatechin‑3‑gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer‑associated fibroblasts

(2022) Shuhai Chen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genistein—Opportunities Related to an Interesting Molecule of Natural Origin

(2022) Ewa Garbiec et al.   MOLECULES

Antihyperglycemic effect of a anthocyanin, cyanidin-3-O-glucoside, is achieved by regulating GLUT-1 via Wnt/β-catenin-WISP1 signaling pathway

(2022) Xiang Ye et al.   Food & Function

Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression

(2022) James Drury et al.   Cancers

The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context

(2022) Faliang Xing et al.   Frontiers in Oncology

Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend?

(2022) J. Ellinger et al.   EPMA Journal

Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care

(2022) Alena Mazurakova et al.   EPMA Journal

Bioavailability of Hesperidin and Its Aglycone Hesperetin—Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)—Mini-Review

(2022) Kamil Wdowiak et al.   Nutrients

Anti-prostate cancer protection and therapy in the framework of predictive, preventive and personalised medicine — comprehensive effects of phytochemicals in primary, secondary and tertiary care

(2022) Alena Mazurakova et al.   EPMA Journal

Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway

(2021) B o Pang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

(2021) Mylène Tajan et al.   Nature Communications

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

(2021) Marek Samec et al.   Cancers

Dietary Luteolin: A Narrative Review Focusing on Its Pharmacokinetic Properties and Effects on Glycolipid Metabolism

(2021) Zhenyu Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Current methodologies to refine bioavailability, delivery, and therapeutic efficacy of plant flavonoids in cancer treatment

(2021) Cijo George Vazhappilly et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo

(2021) Tiago De Oliveira et al.   Cancers

Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

(2021) Lenka Koklesova et al.   EPMA Journal

Flavonoids-Macromolecules Interactions in Human Diseases with Focus on Alzheimer, Atherosclerosis and Cancer

(2021) Dana Atrahimovich et al.   Antioxidants

Isoangustone A induces autophagic cell death in colorectal cancer cells by activating AMPK signaling

(2021) Shunan Tang et al.   FITOTERAPIA

Glutathione in the Brain

(2021) Koji Aoyama   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CPT2 down-regulation promotes tumor growth and metastasis through inducing ROS/NFκB pathway in ovarian cancer

(2021) Xiaohong Zhang et al.   Translational Oncology

Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities

(2021) Ganjun Yuan et al.   Scientific Reports

Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

(2021) Alena Liskova et al.   EPMA Journal

SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

(2021) Lei Feng et al.   Journal of Translational Medicine

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

(2021) Haejin Yoon et al.   MOLECULAR CELL

The Therapeutic Effects and Mechanisms of Quercetin on Metabolic Diseases: Pharmacological Data and Clinical Evidence

(2021) Huan Yi et al.   Oxidative Medicine and Cellular Longevity

The Pro-Health Benefits of Morusin Administration—An Update Review

(2021) Anita Panek-Krzyśko et al.   Nutrients

Epigenetic Alterations Upstream and Downstream of p53 Signaling in Colorectal Carcinoma

(2021) Maja T. Tomicic et al.   Cancers

Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

(2021) Raghad Khalid AL-Ishaq et al.   Cancers

Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy

(2021) Isabella Giacomini et al.   Frontiers in Oncology

Corrigendum: Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K–AKT Pathway and Activating the AMPK–ROS Pathway

(2021) Xuan Wei et al.   Frontiers in Oncology

Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

(2021) Olga Golubnitschaja et al.   EPMA Journal

Myricetin: A comprehensive review on its biological potentials

(2021) Muhammad Imran et al.   Food Science & Nutrition

FV-429 enhances the efficacy of paclitaxel in NSCLC by reprogramming HIF-1α-modulated FattyAcid metabolism

(2021) Yongjian Guo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antitumor Effect of Morusin via G1 Arrest and Antiglycolysis by AMPK Activation in Hepatocellular Cancer

(2021) Ah-Reum Cho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How cancer cells remodel lipid metabolism: strategies targeting transcription factors

(2021) Do-Won Jeong et al.   Lipids in Health and Disease

Targeting cancer metabolism in the era of precision oncology

(2021) Zachary E. Stine et al.   NATURE REVIEWS DRUG DISCOVERY

Role of Flavonoids as Epigenetic Modulators in Cancer Prevention and Therapy

(2021) Nishat Fatima et al.   Frontiers in Genetics

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

(2021) Ser Yue Loo et al.   Science Advances

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

(2021) Peter Kubatka et al.   EPMA Journal

Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person

(2021) Lenka Koklesova et al.   EPMA Journal

NRF2 in regulating cancer metabolism

(2020) Katarína Smolková et al.   ANTIOXIDANTS & REDOX SIGNALING

Apoptosis Induced by (−)-Epicatechin in Human Breast Cancer Cells is Mediated by Reactive Oxygen Species

(2020) Fernando Pereyra-Vergara et al.   MOLECULES

MicroRNA-195 Functions as a Tumor Suppressor by Directly Targeting Fatty Acid Synthase in Malignant Meningioma

(2020) Lai-Rong Song et al.   World Neurosurgery

Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review

(2020) Houssam Al-Koussa et al.   Cancer Cell International

NRF2 as a regulator of cell metabolism and inflammation in cancer

(2020) Feng He et al.   CARCINOGENESIS

Targeting apoptosis in cancer therapy

(2020) Benedito A. Carneiro et al.   Nature Reviews Clinical Oncology

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

(2020) Clayton Hardman et al.   Nature Communications

Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability

(2020) Anna Mas-Capdevila et al.   Nutrients

Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway

(2020) Bing-Huei Chen et al.   Scientific Reports

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

(2020) Lenka Koklesova et al.   EPMA Journal

Quercetin overcomes colon cancer cells resistance to chemotherapy by inhibiting solute carrier family 1, member 5 transporter

(2020) Yuanyuan Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

(2020) Jiao Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Metabolic Reprogramming of Chemoresistant Cancer Cells and the Potential Significance of Metabolic Regulation in the Reversal of Cancer Chemoresistance

(2020) Xun Chen et al.   Metabolites

Inhibitors of Fatty Acid Synthesis and Oxidation as Potential Anticancer Agents in Colorectal Cancer Treatment

(2020) PAULINA MOZOLEWSKA et al.   ANTICANCER RESEARCH

Targeting Lipid Metabolism in Liver Cancer

(2020) Malak Alannan et al.   BIOCHEMISTRY

Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells

(2020) Ahmed Ghdhban Al-Ziaydi et al.   Cancer Cell International

FABP5 as a novel molecular target in prostate cancer

(2020) Saoirse Elizabeth O'Sullivan et al.   DRUG DISCOVERY TODAY

Implications of flavonoids as potential modulators of cancer neovascularity

(2020) Alena Liskova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis

(2020) Marek Samec et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Chemoprevention of Prostate Cancer Cells by Vitamin C plus Quercetin: role of Nrf2 in Inducing Oxidative Stress

(2020) Ali Abbasi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

ACLY: A biomarker of recurrence in breast cancer

(2020) Yue Chen et al.   PATHOLOGY RESEARCH AND PRACTICE

Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer

(2020) Xiaopeng Xiong et al.   Cell Death & Disease

Antiviral Properties of Flavonoids and Delivery Strategies

(2020) Paolino Ninfali et al.   Nutrients

Oxymatrine Inhibits Colorectal Cancer Metastasis via Attenuating PKM2-Mediated Aerobic Glycolysis

(2020) Xiaoping Li et al.   Cancer Management and Research

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer

(2020) Janine M. DeBlasi et al.   Cancers

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

(2020) Linyuan Xue et al.   Frontiers in Oncology

Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression

(2020) Tianyi Chen et al.   Journal of Gastrointestinal Oncology

Serine, glycine and one‑carbon metabolism in cancer (Review)

(2020) Sijing Pan et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Lipid metabolism and cancer

(2020) Xueli Bian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic ablation of FASN attenuates the invasive potential of prostate cancer driven by Pten loss

(2020) Débora C Bastos et al.   JOURNAL OF PATHOLOGY

Toxicological Screening of Four Bioactive Citroflavonoids: In Vitro, In Vivo, and In Silico Approaches

(2020) Rolffy Ortiz-Andrade et al.   MOLECULES

PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition

(2020) Hui Xiao et al.   Analytical Cellular Pathology

Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity

(2020) Ling Jin et al.   Scientific Reports

Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women

(2020) Jing Yang et al.   Cancers

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

(2020) Morana Jaganjac et al.   Antioxidants

Lipid Metabolism and Resistance to Anticancer Treatment

(2020) Nicolas Germain et al.   Biology-Basel

Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma

(2020) Veronica Valvo et al.   THYROID

Liposomes actively recognizing the glucose transporter GLUT1 and integrin αv β3 for dual-targeting of glioma

(2019) Qiuyi Fu et al.   ARCHIV DER PHARMAZIE

Green tea-induced epigenetic reactivation of tissue inhibitor of matrix metalloproteinase-3 suppresses prostate cancer progression through histone-modifying enzymes

(2019) Gauri Deb et al.   MOLECULAR CARCINOGENESIS

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Luteolin, a flavonoid, as an anticancer agent: A review

(2019) Muhammad Imran et al.   BIOMEDICINE & PHARMACOTHERAPY

Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells

(2019) Dongxiao Su et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression

(2019) Marek Samec et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma

(2019) Jiao Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway

(2019) Hongyan Wu et al.   MOLECULES

Glut 1 in Cancer Cells and the Inhibitory Action of Resveratrol as A Potential Therapeutic Strategy

(2019) Angara Zambrano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

(2019) Swati Dabral et al.   Nature Communications

A Possible Mechanism: Genistein Improves Metabolism and Induces White Fat Browning Through Modulating Hypothalamic Expression of Ucn3, Depp, and Stc1

(2019) Liyuan Zhou et al.   Frontiers in Endocrinology

DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions

(2019) Karin Jasek et al.   Biomolecules

Fluvastatin inhibits HMG-CoA reductase and prevents non-small cell lung carcinogenesis

(2019) Tianshun Zhang et al.   Cancer Prevention Research

ACLY facilitates colon cancer cell metastasis by CTNNB1

(2019) Jun Wen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Alternating consumption of β‐glucan and quercetin reduces mortality in mice with colorectal cancer

(2019) Jiamei Qi et al.   Food Science & Nutrition

A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

(2019) Hande Gül Ulusoy et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Flavonoid GL-V9 induces apoptosis and inhibits glycolysis of breast cancer via disrupting GSK-3β-modulated mitochondrial binding of HKII

(2019) Yongjian Guo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

(2019) Juanjuan Zhao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

(2019) Alex J. Bott et al.   Cell Reports

Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFκB) Signaling in Cardiovascular Diseases: A Mini Review

(2019) Ker Woon Choy et al.   Frontiers in Pharmacology

The Role of Nrf2 Activity in Cancer Development and Progression

(2019) Alina-Andreea Zimta et al.   Cancers

The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity

(2019) Jijun Tan et al.   Antioxidants

Reprogramming of fatty acid metabolism in cancer

(2019) Nikos Koundouros et al.   BRITISH JOURNAL OF CANCER

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Quercetin inhibition of SREBPs and ChREBP expression results in reduced cholesterol and fatty acid synthesis in C6 glioma cells

(2019) Fabrizio Damiano et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

(2019) Hardeep Singh Tuli et al.   Frontiers in Pharmacology

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

(2019) Marek Samec et al.   Biomolecules

Targeting Glutamine Metabolism for Cancer Treatment

(2018) Yeon-Kyung Choi et al.   Biomolecules & Therapeutics

Flavonoid metabolism: the interaction of metabolites and gut microbiota

(2018) Kaeko Murota et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mutant p53 in breast cancer: potential as a therapeutic target and biomarker

(2018) Michael J. Duffy et al.   BREAST CANCER RESEARCH AND TREATMENT

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression

(2018) Lv Yao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction

(2018) Lijun Jia et al.   LIFE SCIENCES

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway

(2018) Janaiya S. Samuels et al.   Nutrition & Metabolism

Downregulation of CPT2 promotes tumorigenesis and chemoresistance to cisplatin in hepatocellular carcinoma

(2018) Meihua Lin et al.   OncoTargets and Therapy

Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis

(2018) Nipin Sp et al.   Nutrients

Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

(2018) Md Nur Alam et al.   Biomed Research International

Fatty acid oxidation: An emerging facet of metabolic transformation in cancer

(2018) Yibao Ma et al.   CANCER LETTERS

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering

(2018) Seyed Mohammad Nabavi et al.   BIOTECHNOLOGY ADVANCES

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Granulin A Synergizes with Cisplatin to Inhibit the Growth of Human Hepatocellular Carcinoma

(2018) Gan Qiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silibinin inhibits endometrial carcinoma via blocking pathways of STAT3 activation and SREBP1-mediated lipid accumulation

(2018) Zhengzheng Shi et al.   LIFE SCIENCES

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

(2018) Shi-You Jiang et al.   Nature Communications

Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets

(2018) Vera Miranda-Gonçalves et al.   Frontiers in Genetics

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach

(2018) Sona Uramova et al.   EPMA Journal

Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance

(2017) Jorge Burns et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis

(2017) Shuhua Shan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acyl-CoA synthetase short-chain family member 2 (ACSS2) is regulated by SREBP-1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells

(2017) Huifen Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Plant flavonoids in cancer chemoprevention: role in genome stability

(2017) Vazhappilly Cijo George et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

(−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice

(2017) Yu-Fei Yao et al.   LIFE SCIENCES

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Chrysin loaded nanostructured lipid carriers (NLCs) triggers apoptosis in MCF-7 cancer cells by inhibiting the Nrf2 pathway

(2017) Mehdi Sabzichi et al.   PROCESS BIOCHEMISTRY

Oroxylin A suppresses the development and growth of colorectal cancer through reprogram of HIF1α-modulated fatty acid metabolism

(2017) Ting Ni et al.   Cell Death & Disease

The role of quercetin and vitamin C in Nrf2-dependent oxidative stress production in breast cancer cells

(2017) Zohreh Mostafavi-Pour et al.   Oncology Letters

Suppression of Nrf2 Activity by Chestnut Leaf Extract Increases Chemosensitivity of Breast Cancer Stem Cells to Paclitaxel

(2017) Yaejin Woo et al.   Nutrients

Apigenin sensitizes BEL-7402/ADM cells to doxorubicin through inhibiting miR-101/Nrf2 pathway

(2017) Ai-Mei Gao et al.   Oncotarget

Apigenin in cancer therapy: anti-cancer effects and mechanisms of action

(2017) Xiaohui Yan et al.   Cell and Bioscience

Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms

(2017) Yuanyuan Luo et al.   Frontiers in Pharmacology

Identification of Epigallocatechin-3- Gallate as an Inhibitor of Phosphoglycerate Mutase 1

(2017) Xiaoguang Li et al.   Frontiers in Pharmacology

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus

(2017) Silvia Tejada et al.   CURRENT MEDICINAL CHEMISTRY

Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice

(2016) Cristobal L. Miranda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity

(2016) W. Lim et al.   BIOLOGY OF REPRODUCTION

Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-Aymice

(2016) Yanqing Zang et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

(2016) V Coothankandaswamy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress

(2016) De Huang et al.   CELL RESEARCH

Luteolin induces cholangiocarcinoma cell apoptosis through the mitochondrial-dependent pathway mediated by reactive oxygen species

(2016) Natthawan Kittiratphatthana et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Arginine-Dual roles as an onconutrient and immunonutrient

(2016) Vance L. Albaugh et al.   JOURNAL OF SURGICAL ONCOLOGY

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

(2016) Columba de la Parra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway

(2016) Gang Zhao et al.   ONCOLOGY REPORTS

Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

(2016) Angel Diaz-Lagares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

SCD1 is associated with tumor promotion, late stage and poor survival in lung adenocarcinoma

(2016) Jun Huang et al.   Oncotarget

Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

(2016) Xiongxiong Liu et al.   Oncotarget

Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis

(2016) Marta Anna Kowalik et al.   Oncotarget

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4

(2016) Candice Sun Hong et al.   Cell Reports

High expression of Fatty Acid-Binding Protein 5 promotes cell growth and metastatic potential of colorectal cancer cells

(2016) Koichiro Kawaguchi et al.   FEBS Open Bio

Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

(2016) Eric C. Woolf et al.   Frontiers in Molecular Neuroscience

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

In Vitro Antioxidant versus Metal Ion Chelating Properties of Flavonoids: A Structure-Activity Investigation

(2016) Sabri Ahmed Cherrak et al.   PLoS One

Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14

(2015) A. N. McCracken et al.   BIOCHEMICAL JOURNAL

Luteolin as an anti-inflammatory and neuroprotective agent: A brief review

(2015) Seyed Fazel Nabavi et al.   BRAIN RESEARCH BULLETIN

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Alternative Fuels for Cancer Cells

(2015) Melissa M. Keenan et al.   CANCER JOURNAL

Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

(2015) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Therapeuticl-asparaginase: upstream, downstream and beyond

(2015) André Moreni Lopes et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

The acetyl-CoA carboxylase enzyme: a target for cancer therapy?

(2015) Chao Wang et al.   Expert Review of Anticancer Therapy

Fatty acid synthase overexpression: target for therapy and reversal of chemoresistance in ovarian cancer

(2015) Dirk O Bauerschlag et al.   Journal of Translational Medicine

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells

(2015) Yuxin Zhou et al.   MOLECULAR CARCINOGENESIS

The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake

(2015) Cláudia Azevedo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)

(2015) Neha Atulkumar Singh et al.   Nutrition Journal

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

(2015) J. Yun et al.   SCIENCE

p53mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

(2015) Xiao-Lan Li   WORLD JOURNAL OF GASTROENTEROLOGY

Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome

(2015) Samuel Legeay et al.   Nutrients

Targeting AMPK for cancer prevention and treatment

(2015) Weidong Li et al.   Oncotarget

Epigenetic activities of flavonoids in the prevention and treatment of cancer

(2015) Christian Busch et al.   Clinical Epigenetics

Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1

(2015) Dhanya K. Nambiar et al.   Oncotarget

Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo

(2014) Song Chian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced Obesity

(2014) Eun-Young Kwon et al.   DIABETES

Regulation of GLUT Transporters by Flavonoids in Androgen-Sensitive and -Insensitive Prostate Cancer Cells

(2014) Pedro Gonzalez-Menendez et al.   ENDOCRINOLOGY

Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways

(2014) Harish Chandra Pal et al.   PLoS One

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

(2013) Sharon M. Louie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway

(2013) Ai-Mei Gao et al.   CARCINOGENESIS

Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway

(2013) Ai-Mei Gao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Flavonoids as dietary regulators of nuclear receptor activity

(2013) Yishai Avior et al.   Food & Function

Flavonoid Bioavailability and Attempts for Bioavailability Enhancement

(2013) Surangi Thilakarathna et al.   Nutrients

The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics

(2013) Pedro M. R. Cruz et al.   Frontiers in Pharmacology

Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells

(2012) Yong Yang et al.   CELL BIOCHEMISTRY AND FUNCTION

Ketone body utilization drives tumor growth and metastasis

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

c-Myc and Cancer Metabolism

(2012) D. M. Miller et al.   CLINICAL CANCER RESEARCH

Fatty Acid Synthase Inhibition by Amentoflavone Suppresses HER2/neu(erbB2) Oncogene in SKBR3 Human Breast Cancer Cells

(2012) Jin Sun Lee et al.   PHYTOTHERAPY RESEARCH

Association of FABP5 Expression With Poor Survival in Triple-Negative Breast Cancer

(2011) Rong-Zong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Diverse mechanisms of growth inhibition by luteolin, resveratrol, and quercetin in MIA PaCa-2 cells: a comparative glucose tracer study with the fatty acid synthase inhibitor C75

(2011) Diane M. Harris et al.   Metabolomics

The role of p53 in cell metabolism

(2010) Xing-ding Zhang et al.   ACTA PHARMACOLOGICA SINICA

Inhibitory effects of four plants flavonoids extracts on fatty acid synthase

(2009) Jun CHEN et al.   JOURNAL OF ENVIRONMENTAL SCIENCES