Review
Biochemistry & Molecular Biology
Ganji Seeta Rama Raju, Eluri Pavitra, Sai Samyuktha Bandaru, Ganji Lakshmi Varaprasad, Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh, Young-Kyu Han
Summary: HOTAIR is an oncogenic non-coding RNA that is strongly associated with tumor grade and prognosis in various carcinomas, including breast cancer (BC). It regulates target genes through sponging and epigenetic mechanisms and controls oncogenic cellular and signaling mechanisms, such as metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by transcriptional and epigenetic mechanisms. This review discusses the regulatory mechanisms of HOTAIR during cancer development and explores its role in BC development, metastasis, and drug resistance. The review also highlights the potential therapeutic applications of HOTAIR in BC management, treatment, and prognosis.
Article
Medicine, General & Internal
Timothy J. Whelan, Sally Smith, Sameer Parpia, Anthony W. Fyles, Anita Bane, Fei-Fei Liu, Eileen Rakovitch, Lynn Chang, Christiaan Stevens, Julie Bowen, Sawyna Provencher, Valerie Theberge, Anna Marie Mulligan, Zuzana Kos, Mohamed A. Akra, K. David Voduc, Tarek Hijal, Ian S. Dayes, Gregory Pond, James R. Wright, Torsten O. Nielsen, Mark N. Levine
Summary: Among women with T1N0 grade 1 or 2 luminal A breast cancer who had undergone breast-conserving surgery and received endocrine therapy, the incidence of local recurrence at 5 years was low without radiotherapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Oncology
Liting Tang, Baohong Jiang, Hongbo Zhu, Ting Gao, Yu Zhou, Fuqiang Gong, Rongfang He, Liming Xie, Yuehua Li
Summary: CircRNAs, a new class of endogenous regulatory RNA molecules, play important roles in the initiation and progression of breast cancer, and have the potential to become new diagnostic and predictive biomarkers of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yifeng Shi, Linnea T. Olsson, Katherine A. Hoadley, Benjamin C. Calhoun, J. S. Marron, Joseph Geradts, Marc Niethammer, Melissa A. Troester
Summary: Approaches for rapidly identifying patients at high risk of early breast cancer recurrence are needed. Image-based methods for prescreening tumor slides stained with hematoxylin and eosin (H&E) could provide temporal and financial efficiency. Deep learning was leveraged to extract image information and train a model to identify recurrence. Our image model identified 70% of early-recurrent low-intermediate grade tumors, providing complementary information for predicting early recurrence compared to existing markers.
Article
Oncology
Chuanxu Luo, Shuang Zhao, Cheng Peng, Chengshi Wang, Kejia Hu, Xiaorong Zhong, Ting Luo, Juan Huang, Donghao Lu
Summary: The study identified 15 mammographic radiomics features associated with breast cancer iDFS in the craniocaudal view but none in the mediolateral oblique view. Two lead features, S(1,-1)SumAverg and WavEnLL_s-6, were found to be associated with favorable and poor iDFS, respectively. These features were linked to eight pathways primarily involving cell cycle regulation in tumor tissues.
BRITISH JOURNAL OF CANCER
(2022)
Article
Immunology
Tao Wang, Xinlei Ba, Xiaonan Zhang, Na Zhang, Guowen Wang, Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Yang Yu, Bing Wang
Summary: Protein tyrosine phosphatases play a significant role in regulating signaling pathways in cancer and have clinical relevance. This study provides comprehensive analysis of the regulatory mechanisms and clinical significance of classical PTPs in various types of cancer and highlights their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Yu-Yang Liao, Wen-Ming Cao
Summary: Chromosomal instability (CIN) is an important marker of cancer, closely related to tumorigenesis, disease progression, treatment efficacy, and patient prognosis. Its clinical significance remains unclear due to limitations in current detection methods. However, studies have shown that CIN is present in 89% of invasive breast cancer cases, indicating its potential for breast cancer diagnosis and treatment. This review provides insights into the types of CIN, detection methods, and its impact on breast cancer development, treatment, and prognosis, aiming to serve as a reference for researchers and clinicians.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Marilyn L. Kwan, Emily Valice, Isaac J. Ergas, Janise M. Roh, Bette J. Caan, Elizabeth M. Cespedes M. Feliciano, Tatjana Kolevska, Terryl J. Hartman, Charles P. P. Quesenberry Jr, Christine B. Ambrosone, Lawrence H. Kushi
Summary: This study examined the impact of short-term alcohol consumption on recurrence and mortality in breast cancer patients. The results showed that alcohol drinking around the time of diagnosis and up to 6 months later was associated with lower risk of all-cause mortality in obese women, while nonobese women may face a higher risk of recurrence.
Review
Biochemistry & Molecular Biology
Yeqin Fu, Qiuhui Yang, Hongjian Yang, Xiping Zhang
Summary: Triple negative breast cancer (TNBC) is a highly malignant and aggressive form of breast cancer that is difficult to treat. Recent research has shown that certain miRNA can impact the development, progression, and recurrence of TNBC, making them potential biomarkers for diagnosis and prognosis. This article summarizes the progress of miRNA research in TNBC and discusses their roles in various aspects of TNBC, proposing a treatment strategy for TNBC through interfering with miRNA expression levels.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valery Adorno-Cruz, Andrew D. Hoffmann, Xia Liu, Nurmaa K. Dashzeveg, Rokana Taftaf, Brian Wray, Ruth A. Keri, Huiping Liu
Summary: The study revealed that miR-206 inhibits ITGA2 to reduce breast cancer stemness and metastasis. Knockdown of ITGA2 suppressed self-renewal, cell cycling, migration, invasion, and lung metastasis, related to CCND1 and ACLY.
Article
Endocrinology & Metabolism
Youyuan Deng, Jianguo Wang, Zhiya Hu, Yurong Cai, Yiping Xu, Ke Xu
Summary: This study explores the immune microenvironment of breast cancer and establishes a prognosis model and prediction tool for the prognosis and drug sensitivity of breast cancer patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cynthia Mark, Jin Sun Lee, Xiaojiang Cui, Yuan Yuan
Summary: Antibody drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs for selective delivery to cancer cells, optimizing treatment effectiveness. ADC research has significantly impacted breast cancer management, providing valuable options. However, important questions remain, such as drug sequencing and overcoming resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Raffaella Massafra, Agnese Latorre, Annarita Fanizzi, Roberto Bellotti, Vittorio Didonna, Francesco Giotta, Daniele La Forgia, Annalisa Nardone, Maria Pastena, Cosmo Maurizio Ressa, Lucia Rinaldi, Anna Orsola Maria Russo, Pasquale Tamborra, Sabina Tangaro, Alfredo Zito, Vito Lorusso
Summary: Breast cancer mortality is often linked to metastasization and recurrence, emphasizing the need for personalized treatment strategies. A prediction model for Breast Cancer Recurrence within 5 and 10 years after diagnosis showed promising results using machine learning algorithms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Marco Pellegrini
Summary: For breast cancer patients, choosing the right adjuvant therapy for preventing tumor relapse and metastases can be challenging. A new machine learning method based on coherent voting networks has been developed to predict 5-year survival rates with improved accuracy and explainability, applicable to other types of cancer as well.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Anastasia Constantinidou, Yiola Marcou, Michael S. Toss, Timothy Simmons, Ryan Bernhisel, Elisha Hughes, Braden Probst, Stephanie Meek, Eleni Kakouri, Georgios Georgiou, Ioanna Zouvani, Gabriella Savvidou, Vanessa Kuhl, Jennifer Doedt, Susanne Wagner, Alexander Gutin, Thomas P. Slavin, Jerry S. Lanchbury, Ralf Kronenwett, Ian O. Ellas, Emad A. Rakha
Summary: This study evaluated the performance of EndoPredict in premenopausal women with breast cancer, and found that the EP molecular score and EPclin score are associated with distant recurrence-free survival in breast cancer patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Xue Li, Ao Xu, Kai Li, Jie Zhang, Qin Li, Gang Zhao, Yue Zhang, Hang Yuan, Yafei Guo, Ping Lin, Lugang Huang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Qianwen Zheng, Qin Li, Gang Zhao, Jie Zhang, Hang Yuan, Di Gong, Yafei Guo, Xinhua Liu, Kai Li, Ping Lin
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Cell Biology
Yafei Guo, Qin Li, Gang Zhao, Jie Zhang, Hang Yuan, Tianyu Feng, Deqiong Ou, Rui Gu, Siqi Li, Kai Li, Ping Lin
Summary: TRIM31 functions as a tumor suppressor in breast cancer by stabilizing and activating p53, inhibiting the proliferation and metastasis of breast cancer cells. The interaction between TRIM31 and p53 plays a critical role in regulating p53 ubiquitination, suggesting a promising therapeutic strategy for treating breast cancer by restoring TRIM31 expression.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Gang Zhao, Qijing Wang, Yue Zhang, Rui Gu, Min Liu, Qin Li, Jie Zhang, Hang Yuan, Tianyu Feng, Deqiong Ou, Siqi Li, Shan Li, Kai Li, Chunfen Mo, Ping Lin
Summary: This study found that DEAD box helicase 17 (DDX17) is involved in the initiation and development of colorectal cancer (CRC) and is associated with aggressive phenotypes and poor prognosis in CRC patients. DDX17 promotes CRC cell migration and epithelial to mesenchymal transition (EMT) by downregulating miR-149-3p, leading to increased expression of CYBRD1. These findings reveal a novel mechanism of DDX17-mediated CRC metastasis and EMT through the miR-149-3p/CYBRD1 pathway.
CELL DEATH & DISEASE
(2023)
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
