Review
Nutrition & Dietetics
Yongsheng Zhu, Gang Chen, Jingjing Diao, Changyuan Wang
Summary: Soybeans are a valuable source of proteins and phytochemicals, such as isoflavones and phenolic compounds. Soy bioactive peptides, released through fermentation or gastrointestinal digestion, have various health benefits, including anti-inflammatory, anticancer, and antidiabetic activities. These peptides can be produced using novel food processing techniques and have the potential to replace chemical-based functional elements in foods and pharmaceutical products.
FRONTIERS IN NUTRITION
(2023)
Article
Plant Sciences
Suresh Pokhrel, Sathish K. Ponniah, Yulin Jia, Oliver Yu, Muthusamy Manoharan
Summary: The study screened transgenic rice lines expressing the isoflavone synthase gene from soybean for rice blast resistance, identifying two transgenic lines with high resistance. This resistance is attributed to the synthesis of isoflavone (genistein) in the rice plants.
Article
Chemistry, Applied
Emelia Smith, Lloyd Condict, John Ashton, Stefan Kasapis
Summary: The interactions and binding mechanisms between soybean glycinin (11S) and genistein were investigated using spectroscopic techniques and molecular docking. The complex was stabilized by non-covalent bonds. The binding location was predominantly on the interior portion of the protein and was mainly stabilized by hydrogen bonds, forming a stable complex within the present conditions of neutral pH and ambient temperature.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Monyca D. Rocha, Rafael D. Chaves, Luisa Freire, Arthur K. R. Pia, Marianna M. Furtado, Veronica O. Alvarenga, Aline Crucello, Leticia S. Lopes, Andre F. M. Santos, Dalia P. Rodrigues, Anderson S. Sant'Ana
Summary: This study aimed to determine the occurrence of Salmonella enterica in the soybean meal production chain, characterize the isolates, and assess the survival of Salmonella Senftenberg 775W in soybeans stored under different temperature conditions. The study found that soybean meal may harbor Salmonella serotypes associated with foodborne disease outbreaks in humans and can be responsible for introducing Salmonella into livestock and animal-derived foods.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Agronomy
Yun-Jiao Zhang, Yi-Bo Pang, Xin-Yi Wang, Yong-Hui Jiang, Daniela D. Herrera-Balandrano, Yan Jin, Su-Yan Wang, Pedro Laborda
Summary: The application of exogenous genistein inhibited soybean plant growth temporarily, increased disease resistance against Xag and fungal pathogen Sclerotinia sclerotiorum. It also enhanced antioxidant capacity, reduced H2O2 level, and promoted phenolics accumulation in infected leaves. Exogenous genistein altered the endogenous isoflavone profile, leading to increased genistin levels with strong antibacterial activity against Xag.
PEST MANAGEMENT SCIENCE
(2022)
Article
Plant Sciences
Jinai Xue, Huiling Gao, Yinghong Xue, Ruixiang Shi, Mengmeng Liu, Lijun Han, Yu Gao, Yali Zhou, Fei Zhang, Haiping Zhang, Xiaoyun Jia, Runzhi Li
Summary: Diacylglycerol acyltransferases (DGAT) are key enzymes in the biosynthesis of triacylglycerol (TAG) in soybean. In this study, two members of the DGAT gene family, GmDGAT3-1 and GmDGAT3-2, were identified. GmDGAT3-2 showed higher expression in various soybean tissues and had strong enzymatic activity in TAG biosynthesis with a preference for monounsaturated fatty acids. Transgenic tobacco plants expressing GmDGAT3-2 had increased seed oil and oleic acid levels. These findings provide insights into TAG biosynthesis and its regulation in soybean.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Food Science & Technology
Thangjam Anand Singh, Grihalakshmi Nongthombam, Gulden Goksen, Harikesh B. Singh, Gaurav Rajauria, Prakash Kumar Sarangi
Summary: Hawaijar, an ethnic vegan fermented soybean food from Manipur, India, is culturally and gastronomically significant. It shares similar characteristics with fermented soybean foods from Southeast Asia and has numerous health benefits due to the presence of functional microorganisms. However, unregulated production and sale have led to food safety issues, including the detection of potentially harmful pathogens. Improved and regulated food production can ensure hygienic and safe Hawaijar, which has the potential to enter the global market as a functional food and nutraceutical product, and contribute to the socioeconomic development of the region. This paper provides a summary of the scientific production methods of fermented soybean, discusses food safety issues, and highlights the health benefits and nutritional value of Hawaijar.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Ravinder Singh, Filiz Koksel
Summary: The study showed that adjusting the particle size distribution, extrusion moisture content and barrel temperature of soybean meal can improve the techno-functional properties of extrudates, providing new opportunities for producing novel food ingredients.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Ludmila Krizova, Zuzana Nemcova, Katerina Dadakova, Maria Chrenkova
Summary: The study aimed to determine the ruminal degradability of dry matter, daidzein, genistein, glycitein, and total isoflavones in ground full-fat soybean and solvent-extracted soybean meal using the in sacco method. The results showed differences in the degradation rates of isoflavones between the two sources, indicating that processing may affect the degradation process in the rumen.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Miao Hu, Xiaoqian Du, Guannan Liu, Yuyang Huang, Baokun Qi, Yang Li
Summary: This study successfully fabricated hydrogel beads with low porosity and high antioxidation activities by using covalent and noncovalent conjugation of soy protein isolate modified with EGCG complexes, followed by complexation with SA. Experimental analysis showed that these hydrogel beads have smoother surfaces, thicker shells, lower porosity, and significantly higher antioxidant activities.
Article
Biotechnology & Applied Microbiology
Yun-Jiao Zhang, Daniela D. Herrera-Balandrano, Xin-Chi Shi, Su-Yan Wang, Pedro Laborda
Summary: This study reports a biocontrol strategy for C. brevisporum using the isolated Paeicilomyces maximus NJC01. NJC01 can inhibit the growth of various plant fungal pathogens and has multiple antifungal mechanisms, such as competition for space and nutrients and the production of secondary metabolites.
BIOLOGICAL CONTROL
(2022)
Article
Agronomy
Ji-Seok Lee, Hong-Sig Kim, Tae-Young Hwang
Summary: This study investigated the protein and isoflavone contents of 300 soybean germplasms from different countries, with findings showing variations both in terms of country of origin and size/color. Protein content was highest in soybeans from Korea, while total isoflavone content was highest in soybeans from Japan. Positive correlation was found among daidzein, glycitein, and genistein isoflavone contents, with a low negative correlation between total isoflavone and protein content.
Article
Biochemistry & Molecular Biology
Ming-Sin Ng, Yee-Shan Ku, Wai-Shing Yung, Sau-Shan Cheng, Chun-Kuen Man, Liu Yang, Shikui Song, Gyuhwa Chung, Hon-Ming Lam
Summary: Soybeans are nutritionally important for humans and animals, rich in proteins, oils, and health-beneficial isoflavones. Research shows that GmMATE1 and GmMATE2 play a role in promoting the accumulation of isoflavones in soybean cells, mainly located in the vacuolar membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Min Chen, Shizhao Li, Itika Arora, Nengjun Yi, Manvi Sharma, Zhenhai Li, Trygve O. Tollefsbol, Yuanyuan Li
Summary: This study aimed to investigate the effects of maternal exposure to genistein (GE), a natural isoflavone enriched in soybean products, on the prevention of overnutrition-induced breast cancer later in life. The results showed that maternal dietary GE treatment improved metabolic functions and delayed mammary tumor development in offspring mice. The study suggested that maternal GE consumption could effectively intervene in early-life obesity-related metabolic disorders and breast cancer by influencing the interplay between early-life gut microbiota, microbial metabolite profiles, and offspring epigenome.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Aunchalee Aussanasuwannakul, Sumitra Boonbumrung, Thidarat Pantoa
Summary: This study aims to demonstrate the complete valorization of soybean residue (okara) through supercritical carbon dioxide extraction (SCE) in the context of food waste valorization. Okara oil (OKO) was separated from full-fat powder (FFP) using SCE with or without ethanol (EtOH) as a cosolvent. The extraction process yielded 18.5% oil after 450 min. The OKO and defatted powder (DFP) exhibited various physicochemical, functional, and health-promoting properties, making them potential food ingredients.
Article
Biochemistry & Molecular Biology
Magdalena Paczkowska-Walendowska, Andrzej Miklaszewski, Daria Szymanowska, Krystyna Skalicka-Wozniak, Judyta Cielecka-Piontek
Summary: Hot Melt Extrusion (HME) technology was developed to improve the rheological properties of blends containing lyophilized Scutellariae baicalensis root extract and chitosan through the use of different ratios of (Hydroxypropyl)methyl cellulose (HPMC) as amorphous matrix formers. The systems were characterized and tablets were prepared from the extrudates. HPMC-based systems showed delayed release of baicalin due to the swelling behavior of HPMC, and the best tabletability properties were observed in the formulation containing lyophilized extract HPMC 50:50 w/w, which maintained good mucoadhesive properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek
Summary: The aim of this study was to prepare and characterize the amorphous dispersions of hesperetin and piperine to enhance their solubility and bioavailability. The amorphous systems were successfully obtained through ball milling and confirmed by XRPD and DSC studies. Amorphization significantly improved the dissolution rate, apparent solubility, permeability, and biological activities of hesperetin and piperine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Paczkowska-Walendowska, Andrzej Miklaszewski, Judyta Cielecka-Piontek
Summary: The optimization of hesperidin extraction from orange peel was conducted to obtain its highest content, by investigating the influence of extraction mixture and temperature. The results showed that methanol and temperature were key parameters for efficient extraction of bioactive compounds. Furthermore, electrospinning technology was used to prepare nanofibers loaded with hesperidin-rich orange peel extract, which exhibited improved solubility and permeability. These nanofibers demonstrated significant antioxidant and anti-inflammatory activities, suggesting their potential buccal applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Rosiak, Judyta Cielecka-Piontek, Robert Skibinski, Kornelia Lewandowska, Waldemar Bednarski, Przemyslaw Zalewski
Summary: The influence of ionizing radiation on the physicochemical properties of quercetin and rutin in the solid state was investigated. The results showed that irradiation caused the formation of a small number of free radicals, but did not change the chemical structure or antioxidant properties of the tested flavonoids. Spectroscopic and chromatographic analyses confirmed the radiostability of quercetin and rutin.
Article
Biochemistry & Molecular Biology
Kamil Wdowiak, Robert Pietrzak, Ewa Tykarska, Judyta Cielecka-Piontek
Summary: To overcome the poor bioavailability of curcumin and piperine, their solubility can be enhanced and bioenhancers can be used to inhibit metabolic transformation processes. The amorphous systems of curcumin and piperine produced using hot-melt extrusion showed improved solubility, permeability, and biological activities. The best system significantly increased dissolution rate, apparent solubility, permeability, and antioxidant and anti-butyrylcholinesterase activities.
Article
Biochemistry & Molecular Biology
Anna Stasilowicz-Krzemien, Natalia Rosiak, Andrzej Miklaszewski, Judyta Cielecka-Piontek
Summary: To improve the bioavailability of caffeic acid, delivery systems were developed using ball milling and freeze-drying techniques to prepare solid dispersions of caffeic acid and magnesium aluminometasilicate. The 1:1 mass ratio solid dispersion obtained from ball milling was the most effective, and its identity was confirmed using X-ray powder diffraction and Fourier-transform infrared spectroscopy techniques. Screening tests demonstrated the improved anti-neurodegenerative activity of caffeic acid with enhanced solubility, inhibiting acetylcholinesterase, butyrylcholinesterase, tyrosinase, and showing antioxidant potential. In silico studies identified the domains of caffeic acid that interacted with enzymes relevant to neuroprotective activity. Furthermore, improved permeability through gastrointestinal tract and blood-brain barrier mimicking membranes validated the in vivo screening tests for anti-neurodegenerative activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Szymon Sip, Anna Sip, Andrzej Miklaszewski, Marcin Zarowski, Judyta Cielecka-Piontek
Summary: This study aimed to develop a zein-based hesperidin system with improved solubility and sustained release profile. Triple systems enriched with solubilizers were utilized, and the best system was found to be hesperidin-zein-Hp & beta;-CD, with solubility improved by more than six times. Additionally, the solubility improvement resulted in enhanced antioxidant activity and inhibition of & alpha;-glucosidase. Release profile analysis confirmed the sustained release of hesperidin while enhancing solubility. Furthermore, the study investigated the ability of selected probiotic bacteria to metabolize hesperidin and its impact on their growth.
Article
Pharmacology & Pharmacy
Anna Stasilowicz-Krzemien, Piotr Szulc, Judyta Cielecka-Piontek
Summary: To improve the bioavailability of cannabinoids upon oral administration, researchers have developed co-dispersion cannabinoid delivery systems using biopolymers and carriers, which enhances the solubility and permeability of cannabinoids. The results demonstrate that the co-dispersion cannabinoid delivery systems have improved dissolution and permeability, showing promise for increased bioavailability of cannabinoids.
Article
Biochemistry & Molecular Biology
Magdalena Paczkowska-Walendowska, Andrzej Miklaszewski, Bozena Michniak-Kohn, Judyta Cielecka-Piontek
Summary: Despite the wide range of effects of polyphenols, their low oral bioavailability limits their usefulness. In this study, red vine leaf extract with optimal antioxidant and anti-inflammatory properties was obtained using the Design of Experiment approach. Nanofibers containing the extract were then developed to improve the release and buccal penetration of resveratrol. This innovative strategy enhances the utilization of active compounds for the development of nutraceuticals.
Article
Biochemistry & Molecular Biology
Anna Stasilowicz-Krzemien, Szymon Sip, Piotr Szulc, Judyta Cielecka-Piontek
Summary: Cannabis leaves contain a range of antioxidants that offer health benefits, and utilizing them can be cost-effective. This study aimed to assess the antioxidant activity of hemp leaves from different cultivars and analyze their cannabinoid profiles. The choice of extractant and extraction conditions significantly influenced the extraction efficiency and antioxidant activity of the active compounds. Ultrasonic-assisted extraction using methanol yielded the highest cannabinoid profile and antioxidant potential in Bialobrzeska leaf extracts.
Article
Biochemistry & Molecular Biology
Anna Stasilowicz-Krzemien, Judyta Cielecka-Piontek
Summary: Lupuli flos extracts exhibit significant antioxidant and enzyme inhibitory activities for neuroprotection. The extract obtained under 5000 PSI and 50 degrees C shows the most beneficial neuroprotective effects. Hydroxypropyl-beta-cyclodextrin in combination with magnesium aluminometasilicate shows the greatest improvement in dissolution profiles for the active compounds.
Article
Biochemistry & Molecular Biology
Anna Stasilowicz-Krzemien, Szymon Sip, Piotr Szulc, Jaroslaw Walkowiak, Judyta Cielecka-Piontek
Summary: Cannabis sativa, a versatile plant with promising potential for various biological activities, was extracted using supercritical carbon dioxide. Cannabinoids, particularly cannabidiol (CBD) and cannabidiolic acid (CBDA), were the dominant compounds found in the extracts. Different hemp varieties exhibited varied antioxidant and neuroprotective properties.
Article
Chemistry, Medicinal
Magdalena Paczkowska-Walendowska, Lidia Tajber, Andrzej Miklaszewski, Judyta Cielecka-Piontek
Summary: This study prepared solid dispersions containing polydatin-rich Polygoni cuspidati extract by hot melt extrusion, aiming to enhance the release of poorly water-soluble compounds. The formulation based on Kollidon (R) VA64 exhibited the best tabletability properties and mucoadhesive properties.
Article
Medicine, General & Internal
Malgorzata Jamka, Agata Czochralska-Duszynska, Edyta Madry, Aleksandra Lisowska, Katarzyna Jonczyk-Potoczna, Judyta Cielecka-Piontek, Pawel Bogdanski, Jaroslaw Walkowiak
Summary: This study aimed to evaluate the effects of CLA supplementation on bone mineral density and content in overweight or obese women. The results showed that three-month CLA supplementation did not improve bone health in this population. However, long-term intervention studies are needed to further investigate the potential benefits of CLA on bone health.
MEDICINA-LITHUANIA
(2023)