Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles

Flavonoids Targeting HIF-1: Implications on Cancer Metabolism

(2021) Marek Samec et al.   Cancers

Anti-VEGF Mediated Immunomodulatory Role of Phytochemicals: Scientific Exposition for Plausible HCC Treatment

(2021) Ayana R. Kumar et al.   CURRENT DRUG TARGETS

Mitochondriopathies as a Clue to Systemic Disorders—Analytical Tools and Mitigating Measures in Context of Predictive, Preventive, and Personalized (3P) Medicine

(2021) Alena Liskova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

(2021) Lenka Koklesova et al.   EPMA Journal

Naringenin Nano-Delivery Systems and Their Therapeutic Applications

(2021) Mohammed Bhia et al.   Pharmaceutics

Flavonoids against the SARS-CoV-2 induced inflammatory storm

(2021) Alena Liskova et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway

(2020) Yana Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flavonoids as Multi-Target Compounds: A Special Emphasis on their Potential as Chemo-adjuvants in Cancer Therapy

(2020) Ajay G. Namdeo et al.   CURRENT PHARMACEUTICAL DESIGN

Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway

(2020) Wencui Kong et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Icariin sensitizes human colon cancer cells to TRAIL‑induced apoptosis via ERK‑mediated upregulation of death receptors

(2020) Buyun Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation

(2020) Yann-Lii Leu et al.   MOLECULES

Quercetin Enhanced Paclitaxel Therapeutic Effects Towards PC-3 Prostate Cancer Through ER Stress Induction and ROS Production

(2020) Xiangyu Zhang et al.   OncoTargets and Therapy

Flavonoids as Anticancer Agents

(2020) Dalia M. Kopustinskiene et al.   Nutrients

Abivertinib in patients with T790M‐positive advanced NSCLC and its subsequent treatment with osimertinib

(2020) Hanping Wang et al.   Thoracic Cancer

Metabolic Symbiosis in Chemoresistance: Refocusing the Role of Aerobic Glycolysis

(2020) Lisi Ma et al.   Frontiers in Oncology

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

(2020) Mariam Abotaleb et al.   Biomolecules

Chemotherapeutic Efficacy Enhancement in P-gp-Overexpressing Cancer Cells by Flavonoid-Loaded Polymeric Micelles

(2020) Ruttiros Khonkarn et al.   AAPS PHARMSCITECH

Research Progress in Flavonoid Anticancer Drugs including synergy with other Approaches

(2020) Yusuf Hussain et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Investigation of possible effects of apigenin, sorafenib and combined applications on apoptosis and cell cycle in hepatocellular cancer cells

(2020) Nazlı Şirin et al.   GENE

Mechanisms of Multidrug Resistance in Cancer Chemotherapy

(2020) Karol Bukowski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Provision and use of radiotherapy in Europe

(2020) Yolande Lievens et al.   Molecular Oncology

Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles

(2020) Shuo Liu et al.   MOLECULAR PHARMACEUTICS

Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses

(2020) Peter Kubatka et al.   MOLECULES

Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review

(2020) Milad Ashrafizadeh et al.   PHYTOTHERAPY RESEARCH

Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

(2020) Alessandra Scagliarini et al.   Cells

Cancer Stem Cells as a Potential Target to Overcome Multidrug Resistance

(2020) Yena Cho et al.   Frontiers in Oncology

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

(2020) Lenka Koklesova et al.   EPMA Journal

Molecular and cellular basis of the anticancer activity of the prenylated flavonoid icaritin in hepatocellular carcinoma

(2020) Christian Bailly   CHEMICO-BIOLOGICAL INTERACTIONS

A new epigallocatechin gallate derivative isolated from Anhua dark tea sensitizes the chemosensitivity of gefitinib via the suppression of PI3K/mTOR and epithelial-mesenchymal transition

(2020) Jianyu Liu et al.   FITOTERAPIA

Poncirin downregulates ATP ‐binding cassette transporters to enhance cisplatin sensitivity in cisplatin‐resistant osteosarcoma cells

(2020) Liujing Zhao et al.   PHYTOTHERAPY RESEARCH

Flavonoids in Cancer Metastasis

(2020) Alena Liskova et al.   Cancers

Prostate cancer management: long-term beliefs, epidemic developments in the early twenty-first century and 3PM dimensional solutions

(2020) Radek Kucera et al.   EPMA Journal

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies: unsupervised machine learning and 3 PM recommendations

(2020) Elisha Goldstein et al.   EPMA Journal

Silibinin down-regulates PD-L1 expression in nasopharyngeal carcinoma by interfering with tumor cell glycolytic metabolism

(2020) Leïla Sarah Sellam et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Implications of flavonoids as potential modulators of cancer neovascularity

(2020) Alena Liskova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

TRAIL therapy and prospective developments for cancer treatment

(2020) Bindu Thapa et al.   JOURNAL OF CONTROLLED RELEASE

Resveratrol Suppresses Cross-Talk between Colorectal Cancer Cells and Stromal Cells in Multicellular Tumor Microenvironment: A Bridge between In Vitro and In Vivo Tumor Microenvironment Study

(2020) Constanze Buhrmann et al.   MOLECULES

Interaction between Immunotherapy and Antiangiogenic Therapy for Cancer

(2020) Koichi Furukawa et al.   MOLECULES

Flavonoids: A complementary approach to conventional therapy of COVID-19?

(2020) Julia Solnier et al.   PHYTOCHEMISTRY REVIEWS

The protoapigenone analog WYC0209 targets CD133+ cells: A potential adjuvant agent against cancer stem cells in urothelial cancer therapy

(2020) Bi-Wen Yeh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers

(2020) Rui Liu et al.   Cell Death & Disease

Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways

(2020) Zhiqiang Wu et al.   Biomed Research International

Liquid Biopsy is Instrumental for 3PM Dimensional Solutions in Cancer Management

(2020) Alena Liskova et al.   Journal of Clinical Medicine

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

(2020) Lenka Koklesova et al.   Cancers

Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions

(2020) Kevin Zhai et al.   Biomolecules

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma

(2020) Peter Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-κB-Nrf2 signaling in colorectal cancer cell

(2020) Ziyuan Wang et al.   PHYTOMEDICINE

Immunotherapy: enhancing the efficacy of this promising therapeutic in multiple cancers

(2019) Jitwadee Inthagard et al.   CLINICAL SCIENCE

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

(2019) Ichrak Riahi-Chebbi et al.   Scientific Reports

Chemotherapy Resistance Explained through Endoplasmic Reticulum Stress-Dependent Signaling

(2019) Entaz Bahar et al.   Cancers

Apigenin Combined With Gefitinib Blocks Autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells

(2019) ZiSheng Chen et al.   Frontiers in Pharmacology

Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2

(2019) So Koh et al.   Nutrients

Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology

(2019) Amit J. Sabnis et al.   TRENDS IN MOLECULAR MEDICINE

Dietary Phytochemicals Targeting Cancer Stem Cells

(2019) Alena Liskova et al.   MOLECULES

Controlling metastatic cancer: the role of phytochemicals in cell signaling

(2019) Andrea Kapinova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

(2019) Ying Fan et al.   BMC CANCER

A novel PI3K/mTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer

(2019) Hye Joung Choi et al.   GYNECOLOGIC ONCOLOGY

Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro

(2019) Kubatka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Scutellarin inhibits hypoxia‐induced epithelial‐mesenchymal transition in bladder cancer cells

(2019) Wei‐Ling Lv et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genistein combined with FOLFOX or FOLFOX–Bevacizumab for the treatment of metastatic colorectal cancer: phase I/II pilot study

(2019) Sofya Pintova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of protein phosphatase 1 stimulates noncanonical ER stress eIF2α activation to enhance fisetin-induced chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells

(2019) Liu et al.   Cancers

Morin Hydrate Reverses Cisplatin Resistance by Impairing PARP1/HMGB1-Dependent Autophagy in Hepatocellular Carcinoma

(2019) Singh et al.   Cancers

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

(2019) Qingmei Ye et al.   Frontiers in Oncology

New Strategies to Overcome Resistance to Chemotherapy and Immune System in Cancer

(2019) Chiara Riganti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells

(2019) Yi-Hsuan Hsiao et al.   PHYTOMEDICINE

Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels

(2019) AL-Ishaq et al.   Biomolecules

Synergistic combination therapy of lung cancer: Cetuximab functionalized nanostructured lipid carriers for the co-delivery of paclitaxel and 5-Demethylnobiletin

(2019) Shenghu Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

(2019) Sarita Saraswati et al.   Cell Communication and Signaling

Enhancing the Therapeutic Efficacy of Daunorubicin and Mitoxantrone with Bavachinin, Candidone, and Tephrosin

(2019) Sina Darzi et al.   Evidence-based Complementary and Alternative Medicine

Resveratrol targeting the Wnt signaling pathway: A focus on therapeutic activities

(2019) Milad Ashrafizadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

(2019) Chieh-Yu Lan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

MULTIOMIC PATTERNS IN BODY FLUIDS: TECHNOLOGICAL CHALLENGE WITH A GREAT POTENTIAL TO IMPLEMENT THE ADVANCED PARADIGM OF 3P MEDICINE

(2019) Christopher Gerner et al.   MASS SPECTROMETRY REVIEWS

Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-κB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin)

(2019) Constanze Buhrmann et al.   Nutrients

Redox-Mediated Mechanism of Chemoresistance in Cancer Cells

(2019) Eun-Kyung Kim et al.   Antioxidants

Flavonoids sensitize tumor cells to radiation: molecular mechanisms and relevance to cancer radiotherapy

(2019) Prabha Tiwari et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress

(2019) Milad Ashrafizadeh et al.   PHYTOTHERAPY RESEARCH

Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship

(2019) Xiaoqing Fan et al.   TOXICOLOGY IN VITRO

Mechanisms of Resistance to PD-1 and PD-L1 Blockade

(2018) Theodore S. Nowicki et al.   CANCER JOURNAL

The challenge of drug resistance in cancer treatment: a current overview

(2018) Michail Nikolaou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice

(2018) SoHyun Bae et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Warburg effect, Lactate Dehydrogenase and Radio/Chemo-therapy efficacy

(2018) Michael I. Koukourakis et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

A novel strategy of EGFR‑TKI combined chemotherapy in the treatment of human lung cancer with EGFR‑sensitive mutation

(2018) Lanlin Zhang et al.   ONCOLOGY REPORTS

Quercetin reversed MDR in breast cancer cells through down-regulating P-gp expression and eliminating cancer stem cells mediated by YB-1 nuclear translocation

(2018) Shizheng Li et al.   PHYTOTHERAPY RESEARCH

Acquired resistance to cancer immunotherapy

(2018) Arianna Draghi et al.   Seminars in Immunopathology

Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients

(2018) Alireza Farsad-Naeimi et al.   Food & Function

Genistein promotes ionizing radiation-induced cell death by reducing cytoplasmic Bcl-xL levels in non-small cell lung cancer

(2018) Zhimin Zhang et al.   Scientific Reports

Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

(2018) Chuan-Hao Jiang et al.   Frontiers in Pharmacology

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification

(2018) Holger Fröhlich et al.   EPMA Journal

Morin decreases galectin-3 expression and sensitizes ovarian cancer cells to cisplatin

(2018) Dominik Bieg et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance

(2018) Peter T. Harrison et al.   Essays in Biochemistry

Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention

(2018) A. Kapinova et al.   Environmental Health and Preventive Medicine

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

(2018) Elizabeth Varghese et al.   Cancers

Liquid biopsy and multiparametric analysis in management of liver malignancies: new concepts of the patient stratification and prognostic approach

(2018) Olga Golubnitschaja et al.   EPMA Journal

Design and synthesis of mixed micellar system for enhanced anticancer efficacy of Paclitaxel through its co-delivery with Naringin

(2018) Tooba Jabri et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry”

(2018) Iris L. K. Wong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer

(2018) Honglin Tang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium

(2018) Luca Falzone et al.   Frontiers in Pharmacology

Flavonoids in Cancer and Apoptosis

(2018) Mariam Abotaleb et al.   Cancers

Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2

(2018) Katja Silbermann et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance

(2017) Romana-Rea Begicevic et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

(2017) Peter Kubatka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes

(2017) Maliheh Moradzadeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice

(2017) Amina M Medhat et al.   TUMOR BIOLOGY

Improving radiotherapy in cancer treatment: Promises and challenges

(2017) Helen H.W. Chen et al.   Oncotarget

Phytochemicals Approach for Developing Cancer Immunotherapeutics

(2017) Shu-Yi Yin et al.   Frontiers in Pharmacology

The KEAP1–NRF2 System in Cancer

(2017) Keiko Taguchi et al.   Frontiers in Oncology

Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?

(2017) Olga Golubnitschaja   EPMA Journal

A phase 1 clinical trial of flavopiridol consolidation in chronic lymphocytic leukemia patients following chemoimmunotherapy

(2016) Farrukh T. Awan et al.   ANNALS OF HEMATOLOGY

Xanthohumol Prevents DNA Damage by Dietary Carcinogens: Results of a Human Intervention Trial

(2016) Christoph Pichler et al.   Cancer Prevention Research

Molecular mechanisms for tumour resistance to chemotherapy

(2016) Shu-Ting Pan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model

(2016) Peter Kubatka et al.   EUROPEAN JOURNAL OF NUTRITION

Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs

(2016) Annamaria Cimini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Anthocyanins inhibit trastuzumab-resistant breast cancer in vitro and in vivo

(2016) XIN LI et al.   Molecular Medicine Reports

Young Barley Indicates Antitumor Effects in Experimental Breast Cancer In Vivo and In Vitro

(2016) Peter Kubatka et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region

(2016) Xiongxiong Liu et al.   Oncotarget

DNA damage repair and tolerance: a role in chemotherapeutic drug resistance

(2016) M. R. Salehan et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

(2015) Peter Kubatka et al.   EUROPEAN JOURNAL OF NUTRITION

EPMA position paper in cancer: current overview and future perspectives

(2015) Godfrey Grech et al.   EPMA Journal

The Molecular Mechanisms of TRAIL Resistance in Cancer Cells: Help in Designing New Drugs

(2014) Feng Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Drug resistance to targeted therapies: Déjà vu all over again

(2014) Floris H. Groenendijk et al.   Molecular Oncology

Nonhomologous End-Joining Repair Plays a More Important Role than Homologous Recombination Repair in Defining Radiosensitivity after Exposure to High-LET Radiation

(2014) Akihisa Takahashi et al.   RADIATION RESEARCH

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance

(2013) Radosław Januchowski et al.   BIOMEDICINE & PHARMACOTHERAPY

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL