SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis

SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production

(2021) Xiaohuan Zhao et al.   Frontiers in Cell and Developmental Biology

Ferroptosis, radiotherapy, and combination therapeutic strategies

(2021) Guang Lei et al.   Protein & Cell

Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer

(2021) Jingjing Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Early Neurotoxic Effects of Inorganic Arsenic Modulate Cortical GSH Levels Associated With the Activation of the Nrf2 and NFκB Pathways, Expression of Amino Acid Transporters and NMDA Receptors and the Production of Hydrogen Sulfide

(2020) Daniela Silva-Adaya et al.   Frontiers in Cellular Neuroscience

Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma

(2020) Yongping Cui et al.   CELL RESEARCH

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

A sensitive assay for dNTPs based on long synthetic oligonucleotides, EvaGreen dye and inhibitor-resistant high-fidelity DNA polymerase

(2020) Janne Purhonen et al.   NUCLEIC ACIDS RESEARCH

Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy

(2020) Di Xia et al.   Cell and Bioscience

Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers

(2020) Bowen Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

(2020) Zhuanzhuan Qiang et al.   Oxidative Medicine and Cellular Longevity

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

(2020) Piergiorgio La Rosa et al.   Redox Biology

Effects of Selenium Nanoparticles Combined With Radiotherapy on Lung Cancer Cells

(2020) Jingxia Tian et al.   Frontiers in Bioengineering and Biotechnology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer

(2019) Chengcheng Gai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

(2019) Eunhee Park et al.   Cell Death & Disease

The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: Implications for photodynamic therapy

(2019) Annalisa Ferino et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A Convergence-Based Framework for Cancer Drug Resistance

(2018) David J. Konieczkowski et al.   CANCER CELL

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Extracellular redox state shift: A novel approach to target prostate cancer invasion

(2018) Weixiong Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma

(2018) Liang Zhang et al.   Future Oncology

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

Alterations in System xc− Expression in the Retina of Type 1 Diabetic Rats and the Role of Nrf2

(2018) Raul Carpi-Santos et al.   MOLECULAR NEUROBIOLOGY

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

(2018) Masaki Nagane et al.   PLoS One

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction

(2018) Lara Cobler et al.   Oncotarget

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Analysis of the effects of polyunsaturated fatty acids on transporter expressions using a PCR array: Induction of xCT/SLC7A11 in human placental BeWo cells

(2018) Kanako Ono et al.   PLACENTA

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

(2018) Xinbing Sui et al.   Frontiers in Pharmacology

Oesophageal cancer

(2017) Jesper Lagergren et al.   LANCET

The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer

(2017) Shasha Tao et al.   MOLECULAR CARCINOGENESIS

NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression

(2017) Delin Chen et al.   MOLECULAR CELL

SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma

(2017) Zhihong Ma et al.   ONCOLOGY REPORTS

BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response

(2017) Fangyan Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis

(2017) Jong-Lyel Roh et al.   Redox Biology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

(2017) Michael John Kerins et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells

(2015) QIUYUE ZHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer

(2015) Tatsuhiro Shibata et al.   NEOPLASIA

Nrf2 is Useful for Predicting the Effect of Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma

(2014) Yota Kawasaki et al.   ANNALS OF SURGICAL ONCOLOGY

Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis

(2013) Hironori Satoh et al.   CANCER RESEARCH

Nrf2 is a potential therapeutic target in radioresistance in human cancer

(2013) Suna Zhou et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

xCT, component of cysteine/glutamate transporter, as an independent prognostic factor in human esophageal squamous cell carcinoma

(2013) Atsushi Shiozaki et al.   JOURNAL OF GASTROENTEROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

(2012) Satoru Takeuchi et al.   NEUROSURGERY

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA