Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach

Premenopausal breast cancer: potential clinical utility of a multi-omics based machine learning approach for patient stratification

(2018) Holger Fröhlich et al.   EPMA Journal

Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles

(2017) Jenny G Parvani et al.   ENDOCRINE-RELATED CANCER

The potential contribution of dietary factors to breast cancer prevention

(2017) Niva Shapira   EUROPEAN JOURNAL OF CANCER PREVENTION

Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer

(2017) Lokesh Dalasanur Nagaprashantha et al.   INTERNATIONAL JOURNAL OF CANCER

Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma

(2017) Peter Kubatka et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Antrodia cinnamomea sensitizes radio-/chemo-therapy of cancer stem-like cells by modulating microRNA expression

(2017) Yu-kai Su et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Flavone Constituent from Myoporum bontioides Induces M-Phase Cell Cycle Arrest of MCF-7 Breast Cancer Cells

(2017) Jing-Ru Weng et al.   MOLECULES

Identification of a Triterpenoid as a Novel PPARγ Activator Derived from Formosan Plants

(2017) Jing-Ru Weng et al.   PHYTOTHERAPY RESEARCH

Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line

(2017) Umesh Kumar et al.   TUMOR BIOLOGY

Dietary Natural Products for Prevention and Treatment of Breast Cancer

(2017) Ya Li et al.   Nutrients

Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells

(2017) Anna Lewinska et al.   Theranostics

The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer

(2017) Nicolas Veland et al.   Cell Reports

Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification?

(2017) Olga Golubnitschaja   EPMA Journal

Postmenopausal breast cancer: European challenge and innovative concepts

(2017) Ivica Smokovski et al.   EPMA Journal

Breast cancer and Flammer syndrome: any symptoms in common for prediction, prevention and personalised medical approach?

(2017) Pavol Zubor et al.   EPMA Journal

“Pre-metastatic niches” in breast cancer: are they created by or prior to the tumour onset? “Flammer Syndrome” relevance to address the question

(2017) Rostyslav Bubnov et al.   EPMA Journal

Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway

(2016) Xiaohong Yang et al.   BMC CANCER

Long-term soy consumption and tumor tissue MicroRNA and gene expression in triple-negative breast cancer

(2016) Xingyi Guo et al.   CANCER

Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The {inverted exclamation}Cocinar Para Su Salud! Randomized Controlled Trial

(2016) H. Greenlee et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Analysis of Long Non-Coding RNA Expression Profiles in Non-Small Cell Lung Cancer

(2016) Li Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nanoparticle-siRNA: A potential cancer therapy?

(2016) Samuel Wang Sherng Young et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Epigenetic targets in cancer and aging: dietary and therapeutic interventions

(2016) Sajid Khan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Down-regulation of lncRNA MALAT1 reduces cardiomyocyte apoptosis and improves left ventricular function in diabetic rats

(2016) Mengyao Zhang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Identifying the crosstalk of dysfunctional pathways mediated by lncRNAs in breast cancer subtypes

(2016) Li Wang et al.   Molecular BioSystems

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

(2016) Youyou Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Soy Isoflavone Genistein-Mediated Downregulation of miR-155 Contributes to the Anticancer Effects of Genistein

(2016) Columba de la Parra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

(2016) Eswar Shankar et al.   SEMINARS IN CANCER BIOLOGY

Breast cancer epidemic in the early twenty-first century: evaluation of risk factors, cumulative questionnaires and recommendations for preventive measures

(2016) Olga Golubnitschaja et al.   TUMOR BIOLOGY

Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

(2016) Youyou Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes

(2016) Terri L. Messier et al.   Oncotarget

Environmental and lifestyle risk factors of breast cancer in Malta—a retrospective case-control study

(2016) John Paul Cauchi et al.   EPMA Journal

Medicine in the early twenty-first century: paradigm and anticipation - EPMA position paper 2016

(2016) Olga Golubnitschaja et al.   EPMA Journal

“Triple-Punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy

(2015) Shishuai Su et al.   ACS Nano

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

(2015) Rishabh Kala et al.   BMC CANCER

Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2′-deoxycytidine in human breast cancer cells

(2015) Tulika Tyagi et al.   BREAST CANCER RESEARCH AND TREATMENT

Long noncoding RNAs in regulation of human breast cancer: Table 1

(2015) Guangxue Wang et al.   Briefings in Functional Genomics

A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis

(2015) Bodu Liu et al.   CANCER CELL

Silencing β3 Integrin by Targeted ECO/siRNA Nanoparticles Inhibits EMT and Metastasis of Triple-Negative Breast Cancer

(2015) Jenny G. Parvani et al.   CANCER RESEARCH

Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

(2015) Jian Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chromatin deregulation in disease

(2015) Anne C. Mirabella et al.   CHROMOSOMA

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal Cancer

(2015) Jennifer Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long non-coding RNA chromogenic in situ hybridisation signal pattern correlation with breast tumour pathology

(2015) Zhouwei Zhang et al.   JOURNAL OF CLINICAL PATHOLOGY

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

(2015) Saeed Pirouzpanah et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells

(2015) Katarzyna Lubecka-Pietruszewska et al.   Journal of Nutrigenetics and Nutrigenomics

Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors

(2015) Lissette Delgado-Cruzata et al.   JOURNAL OF NUTRITION

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells

(2015) Francesca De Amicis et al.   Molecular Cancer

Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells

(2015) Kris G. Hargraves et al.   MOLECULAR CARCINOGENESIS

Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis

(2015) Jun Dong et al.   TUMOR BIOLOGY

The growth arrest-specific transcript 5 (GAS5): a pivotal tumor suppressor long noncoding RNA in human cancers

(2015) Chenhui Ma et al.   TUMOR BIOLOGY

Long non-coding RNA MVIH is associated with poor prognosis and malignant biological behavior in breast cancer

(2015) Bo Lei et al.   TUMOR BIOLOGY

Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer

(2015) Shou-ping Xu et al.   TUMOR BIOLOGY

Association of BRCA1 promoter methylation with sporadic breast cancers: Evidence from 40 studies

(2015) Li Zhang et al.   Scientific Reports

Epigenetic activities of flavonoids in the prevention and treatment of cancer

(2015) Christian Busch et al.   Clinical Epigenetics

Probiotics and immunity: provisional role for personalized diets and disease prevention

(2015) Rostyslav V. Bubnov et al.   EPMA Journal

Actionable pharmacogenetic markers for prediction and prognosis in breast cancer

(2015) Keith Sacco et al.   EPMA Journal

The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model

(2015) Cristina Rodríguez-Miguel et al.   PLoS One

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations

(2015) Roxana S Redis et al.   Oncotarget

Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core–shell nanoparticles

(2014) Qiang Feng et al.   BIOMATERIALS

Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention

(2014) Samriddhi Shukla et al.   CANCER LETTERS

Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats

(2014) Terézia Kisková et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells

(2014) Qi Xie et al.   GENES CHROMOSOMES & CANCER

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

(2014) Pranapda Aumsuwan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors

(2014) Beate Schultheis et al.   JOURNAL OF CLINICAL ONCOLOGY

Triple negative breast cancer therapy with CDK1 siRNA delivered by cationic lipid assisted PEG-PLA nanoparticles

(2014) Yang Liu et al.   JOURNAL OF CONTROLLED RELEASE

miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2

(2014) Emanuel Kronski et al.   Molecular Oncology

Methylation and miRNA Effects of Resveratrol on Mammary Tumors vs. Normal Tissue

(2014) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Curcumin Modulates miR-19/PTEN/AKT/p53 Axis to Suppress Bisphenol A-induced MCF-7 Breast Cancer Cell Proliferation

(2014) Xiaoting Li et al.   PHYTOTHERAPY RESEARCH

Impact of Soy Isoflavones on the Epigenome in Cancer Prevention

(2014) Maria Pudenz et al.   Nutrients

DNA Methyltransferases: A Novel Target for Prevention and Therapy

(2014) Dharmalingam Subramaniam et al.   Frontiers in Oncology

Plant Phytochemicals as Epigenetic Modulators: Role in Cancer Chemoprevention

(2013) Vijay S. Thakur et al.   AAPS Journal

Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment

(2013) Zhou J. Deng et al.   ACS Nano

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

(2013) Hilary M Collins et al.   BMC CANCER

Differential expression of histone deacetylases HDAC1, 2 and 3 in human breast cancer - overexpression of HDAC2 and HDAC3 is associated with clinicopathological indicators of disease progression

(2013) Berit Maria Müller et al.   BMC CANCER

Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer

(2013) Kristina P. Sørensen et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting Epigenetics for Cancer Prevention By Dietary Cancer Preventive Compounds--The Case of miRNA

(2013) A.-N. T. Kong et al.   Cancer Prevention Research

DNA Methylation and Cancer Development: Molecular Mechanism

(2013) Haleh Akhavan-Niaki et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Effect of green tea catechins on breast carcinogenesis

(2013) Eugenia Ch. Yiannakopoulou   EUROPEAN JOURNAL OF CANCER PREVENTION

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Chemopreventive and Therapeutic Activity of Dietary Blueberry against Estrogen-Mediated Breast Cancer

(2013) Jeyaprakash Jeyabalan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of a Stem-like Subpopulation in Basal-like Ductal Carcinomain Situ(DCIS) Lesions

(2013) Qinglin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

(2013) Sameer Mirza et al.   Journal of Breast Cancer

Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a

(2013) Jiaoli Guo et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer

(2013) Yuanyuan Li et al.   Molecular Cancer

Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells

(2013) Eun-Ryeong Hahm et al.   MOLECULAR CARCINOGENESIS

Identification of Kazinol Q, a Natural Product from Formosan Plants, as an Inhibitor of DNA Methyltransferase

(2013) Jing-Ru Weng et al.   PHYTOTHERAPY RESEARCH

Epigenetic Regulation of Multiple Tumor-Related Genes Leads to Suppression of Breast Tumorigenesis by Dietary Genistein

(2013) Yuanyuan Li et al.   PLoS One

3, 3′-diindolylmethane Enhances the Effectiveness of Herceptin against HER-2/Neu-Expressing Breast Cancer Cells

(2013) Aamir Ahmad et al.   PLoS One

Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines

(2013) Aslihan Dagdemir et al.   Epigenomics

DNA methylation and differentiation: silencing, upregulation and modulation of gene expression

(2013) Melanie Ehrlich et al.   Epigenomics

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Risk assessment, disease prevention and personalised treatments in breast cancer: is clinically qualified integrative approach in the horizon?

(2013) Olga Golubnitschaja et al.   EPMA Journal

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation

(2012) Nivedita Banerjee et al.   BREAST CANCER RESEARCH AND TREATMENT

Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer

(2012) Lingeng Lu et al.   BREAST CANCER RESEARCH AND TREATMENT

DNA methylation biomarkers and their utility for solid cancer diagnostics

(2012) Karen A. Heichman et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Cancer prevention in Europe

(2012) Attilio Giacosa et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer

(2012) Katarzyna Augoff et al.   Molecular Cancer

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Diallyl Disulfide-Induced Apoptosis in a Breast-Cancer Cell Line (MCF-7) May Be Caused by Inhibition of Histone Deacetylation

(2012) Mohammed O. Altonsy et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Reactivation of RASSF1A in Breast Cancer Cells by Curcumin

(2012) Liping Du et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effects ofThymus serpyllumExtract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells

(2012) Emir Bozkurt et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Bioactive Dietary Supplements Reactivate ER Expression in ER-Negative Breast Cancer Cells by Active Chromatin Modifications

(2012) Syed M. Meeran et al.   PLoS One

Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators

(2012) Mudit Vaid et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity

(2012) Keitaro Hagiwara et al.   Scientific Reports

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells

(2011) S. M. Meeran et al.   Cancer Prevention Research

Epigenetic Modifications

(2011) Diane E. Handy et al.   CIRCULATION

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

(2011) G. C. Hon et al.   GENOME RESEARCH

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains

(2011) Benjamin P Berman et al.   NATURE GENETICS

Histone onco-modifications

(2011) J Füllgrabe et al.   ONCOGENE

MicroRNAs and Cancer Therapeutics

(2011) Man Lung Yeung et al.   PHARMACEUTICAL RESEARCH

Epigenetic diet: impact on the epigenome and cancer

(2011) Tabitha M Hardy et al.   Epigenomics

Glyceollins as novel targeted therapeutic for the treatment of triple-negative breast cancer

(2011) LYNDSAY V. RHODES et al.   Oncology Letters

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

(2010) Samir Attoub et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Promise and Challenge of RNA Interference–Based Therapy for Cancer

(2010) Fabio Petrocca et al.   JOURNAL OF CLINICAL ONCOLOGY

Resveratrol Prevents Epigenetic Silencing of BRCA-1 by the Aromatic Hydrocarbon Receptor in Human Breast Cancer Cells

(2010) Andreas J. Papoutsis et al.   JOURNAL OF NUTRITION

Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop

(2010) Crystal N. Marconett et al.   MOLECULAR BIOLOGY OF THE CELL

Synergistic epigenetic reactivation of estrogen receptor-alpha (ERalpha) by combined green tea polyphenol and histone deacetylase inhibitor in ERalpha-negative breast cancer cells

(2010) Yuanyuan Li et al.   Molecular Cancer

Global Histone Modifications in Breast Cancer Correlate with Tumor Phenotypes, Prognostic Factors, and Patient Outcome

(2009) S. E. Elsheikh et al.   CANCER RESEARCH

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: Studies with sulforaphane and garlic organosulfur compounds

(2009) Hui Nian et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing

(2008) H. H. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA