Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway

Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes

(2012) Chin-Shiu Huang et al.   ARCHIVES OF TOXICOLOGY

Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression

(2012) Ke Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A New Model for Raf Kinase Inhibitory Protein Induced Chemotherapeutic Resistance

(2012) Fahd Al-Mulla et al.   PLoS One

Involvement of the aldo–keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms

(2011) Toshiyuki Matsunaga et al.   ANTI-CANCER DRUGS

Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells

(2011) Ziwen Liu et al.   BIOCHEMICAL JOURNAL

Regulation of aldo–keto reductase AKR1B10 gene expression: Involvement of transcription factor Nrf2

(2011) Toru Nishinaka et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs

(2011) Xiuwen Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1

(2011) Young Jin Seo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

(2011) D. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Drug Efflux Transporter Multidrug Resistance-Associated Protein 5 Affects Sensitivity of Pancreatic Cancer Cell Lines to the Nucleoside Anticancer Drug 5-Fluorouracil

(2010) P. K. Nambaru et al.   DRUG METABOLISM AND DISPOSITION

Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

(2010) P. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Hepatocellular carcinoma: a global view

(2010) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells

(2010) Young Bin Hong et al.   PANCREAS

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

(2009) S. Homma et al.   CLINICAL CANCER RESEARCH

Identification and expression analysis of the aldo–ketoreductase1-B10 gene in primary malignant liver tumours

(2009) Stefan Heringlake et al.   JOURNAL OF HEPATOLOGY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

The Gene Expression Profiles of Medulloblastoma Cell Lines Resistant to Preactivated Cyclophosphamide

(2008) M. Bacolod et al.   CURRENT CANCER DRUG TARGETS

Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: Implication to cancer cell resistance

(2007) Jeong-Min Cho et al.   CANCER LETTERS