Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance

Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective

(2018) Pietro Ghezzi et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences

(2017) Ye Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

(2017) Sanghoon Kwon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of the Warburg effect in non-tumor diseases processes

(2017) Zhe Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Shielding assessment of high field (QED) experiments at the ELI-NP 10 PW laser system

(2017) M A Popovici et al.   JOURNAL OF RADIOLOGICAL PROTECTION

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis

(2017) Young Cha et al.   NATURE CELL BIOLOGY

Oxygen and placental development; parallels and differences with tumour biology

(2017) Graham J. Burton et al.   PLACENTA

Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?

(2017) Michael J. Pecaut et al.   PLoS One

Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia

(2017) Louise Y. Fong et al.   Oncotarget

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

Laser-plasma-based Space Radiation Reproduction in the Laboratory

(2017) B. Hidding et al.   Scientific Reports

Epigenetic determinants of space radiation-induced cognitive dysfunction

(2017) Munjal M. Acharya et al.   Scientific Reports

The impact of microgravity on bone in humans

(2016) Daniela Grimm et al.   BONE

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases

(2016) Mun Chiang Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development

(2016) Michael A. Schmidt et al.   Metabolomics

Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy

(2016) Kathryn D. Held et al.   RADIATION RESEARCH

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Normal tissue radioprotection by amifostine via Warburg-type effects

(2016) Michael I. Koukourakis et al.   Scientific Reports

A systems biology pipeline identifies new immune and disease related molecular signatures and networks in human cells during microgravity exposure

(2016) Sayak Mukhopadhyay et al.   Scientific Reports

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

(2016) Hiroko P. Indo et al.   Scientific Reports

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

(2016) Elena V. Knatko et al.   Scientific Reports

Multimodality Imaging Identifies Distinct Metabolic Profiles In Vitro and In Vivo

(2016) Marie-Aline Neveu et al.   NEOPLASIA

Transcription Factors in the Cellular Response to Charged Particle Exposure

(2016) Christine E. Hellweg et al.   Frontiers in Oncology

Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities

(2016) Audrey Bergouignan et al.   NPJ Microgravity

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Combined Exposure to Simulated Microgravity and Acute or Chronic Radiation Reduces Neuronal Network Integrity and Survival

(2016) Giuseppe Pani et al.   PLoS One

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism

(2015) Dionysios V. Chartoumpekis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial dysfunction: the missing link between aging and sporadic Alzheimer’s disease

(2015) Amandine Grimm et al.   BIOGERONTOLOGY

Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis

(2015) Blake R Wilde et al.   BRITISH JOURNAL OF CANCER

Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells

(2015) Sundarraj Jayakumar et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Radium Girls

(2015) Richard B. Gunderman et al.   RADIOLOGY

Gene expression signatures of breast cancer stem and progenitor cells do not exhibit features of Warburg metabolism

(2015) Nicole Gordon et al.   Stem Cell Research & Therapy

Warburg Effect or Reverse Warburg Effect? A Review of Cancer Metabolism

(2015) Xiao Dong Xu et al.   Oncology Research and Treatment

The redox biology network in cancer pathophysiology and therapeutics

(2015) Gina Manda et al.   Redox Biology

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis

(2015) Cheng Zhan et al.   PLoS One

Changes in Stress Hormones and Metabolism During a 105-Day Simulated Mars Mission

(2014) Felice Strollo et al.   AVIATION SPACE AND ENVIRONMENTAL MEDICINE

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase

(2013) Ching-An Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

miR-143 inhibits glycolysis and depletes stemness of glioblastoma stem-like cells

(2013) Shiguang Zhao et al.   CANCER LETTERS

Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment

(2013) Ubaldo E Martinez-Outschoorn et al.   CELL CYCLE

Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts

(2013) Bingrong Dang et al.   LIFE SCIENCES

Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease

(2013) Jonathan D. Cherry et al.   PLoS One

Down-regulated expression of the protein-tyrosine phosphatase 1B (PTP1B) is associated with aggressive clinicopathologic features and poor prognosis in hepatocellular carcinoma

(2012) Long-Yi Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cultured senescent myoblasts derived from human vastus lateralis exhibit normal mitochondrial ATP synthesis capacities with correlating concomitant ROS production while whole cell ATP production is decreased

(2012) Ariane D. Minet et al.   BIOGERONTOLOGY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

PTP1B Is an Androgen Receptor-Regulated Phosphatase That Promotes the Progression of Prostate Cancer

(2012) L. Lessard et al.   CANCER RESEARCH

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells

(2012) Ahmed F. Salem et al.   CELL CYCLE

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

(2012) Michael Volkmar et al.   EMBO JOURNAL

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

(2012) Wenyu Zhou et al.   EMBO JOURNAL

Induction of muscle regeneration by RNA-mediated mitochondrial restoration

(2012) Sukanta Jash et al.   FASEB JOURNAL

A role for the Warburg effect in preimplantation embryo development: Metabolic modification to support rapid cell proliferation

(2012) Rebecca L. Krisher et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

The microcosmos of cancer

(2012) Amaia Lujambio et al.   NATURE

Public health: The toxic truth about sugar

(2012) Robert H. Lustig et al.   NATURE

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury

(2012) Mohammad Naimul Islam et al.   NATURE MEDICINE

Assessment of mitochondrial respiratory chain enzymatic activities on tissues and cultured cells

(2012) Marco Spinazzi et al.   Nature Protocols

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lifestyle Change and Mobility in Obese Adults with Type 2 Diabetes

(2012) W. Jack Rejeski et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of glycolysis and the Warburg effect by estrogen-related receptors

(2012) Q Cai et al.   ONCOGENE

Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration

(2012) R Palorini et al.   ONCOGENE

Human Embryonic Stem Cells and Embryonal Carcinoma Cells Have Overlapping and Distinct Metabolic Signatures

(2012) Raed Abu Dawud et al.   PLoS One

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Von Hippel–Lindau: How a rare disease illuminates cancer biology

(2012) Stéphane Richard et al.   SEMINARS IN CANCER BIOLOGY

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Determinants of Brain Cell Metabolic Phenotypes and Energy Substrate Utilization Unraveled with a Modeling Approach

(2012) Aitana Neves et al.   PLoS Computational Biology

Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: Marker or maker of the diabetic phenotype?

(2012) Michael Gaster et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging

(2011) Águeda González-Rodríguez et al.   AGING CELL

Differential Gene Expression Profile in Bovine Blastocysts Resulting from Hyperglycemia Exposure During Early Cleavage Stages1

(2011) Gaël L. M. Cagnone et al.   BIOLOGY OF REPRODUCTION

Combining Metabolic Pathway Analysis with Evolutionary Game Theory. Explaining the occurrence of low-yield pathways by an analytic optimization approach

(2011) Stefan Schuster et al.   BIOSYSTEMS

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

(2011) M. R. Doe et al.   CANCER RESEARCH

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

(2011) Aftabul Haque et al.   CELL

Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo

(2011) Joseph L. Sottnik et al.   CLINICAL & EXPERIMENTAL METASTASIS

The epigenetic basis of the Warburg effect

(2011) Xian Wang et al.   Epigenetics

Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome

(2011) D. K. Gardner et al.   HUMAN REPRODUCTION

A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells

(2011) M. J. Birket et al.   JOURNAL OF CELL SCIENCE

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteomic Analysis Reveals Warburg Effect and Anomalous Metabolism of Glutamine in Pancreatic Cancer Cells

(2011) Weidong Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Respiratory competent mitochondria in human ovarian and peritoneal cancer

(2011) Hwee Ying Lim et al.   MITOCHONDRION

Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells

(2011) J. Fan et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

From fertilization to cancer: A lifelong pursuit into how cells use oxygen. Otto Heinrich Warburg (October 8, 1883 - August 1, 1970)

(2011) Julian L. Wong   MOLECULAR REPRODUCTION AND DEVELOPMENT

Glycolysis in preimplantation development is partially controlled by the Warburg Effect

(2011) Bethany K. Redel et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Mesenchymal Stromal Cells Protect Cancer Cells From ROS-induced Apoptosis and Enhance the Warburg Effect by Secreting STC1

(2011) Shinya Ohkouchi et al.   MOLECULAR THERAPY

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

(2011) Sabine D. Jordan et al.   NATURE CELL BIOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Oxidized LDL Receptor 1 (OLR1) as a Possible Link between Obesity, Dyslipidemia and Cancer

(2011) Magomed Khaidakov et al.   PLoS One

Type 2 Diabetes Is Associated with Altered NF-κB DNA Binding Activity, JNK Phosphorylation, and AMPK Phosphorylation in Skeletal Muscle after LPS

(2011) Anne Sofie Andreasen et al.   PLoS One

The involvement of microRNAs in Type 2 diabetes

(2010) David Ferland-McCollough et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

(2010) Christian Frezza et al.   CANCER CELL

Histone acetylation: Where to go and how to get there

(2010) Vicki E. MacDonald et al.   Epigenetics

Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells

(2010) Katarína Smolková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes

(2010) Pasi Tavi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

(2010) Preeti Ahuja et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1α and HIF-2α

(2010) Donghoon Yoon et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tight control of mitochondrial membrane potential by cytochrome c oxidase

(2010) Consiglia Pacelli et al.   MITOCHONDRION

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Mitochondrial Gene Deletion on Tumorigenicity of Metastatic Melanoma: Reassessing the Warburg Effect

(2010) Michael V. Berridge et al.   REJUVENATION RESEARCH

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

The Role of Dysregulated Glucose Metabolism in Epithelial Ovarian Cancer

(2010) L. D. Kellenberger et al.   Journal of Oncology

Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

(2009) M. A. Tarnopolsky   Applied Physiology Nutrition and Metabolism

Poly(C)-binding proteins as transcriptional regulators of gene expression

(2009) Hack Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives

(2009) Javier A. Menendez   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion

(2009) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells

(2009) Sandro M. Hirabara et al.   JOURNAL OF CELLULAR PHYSIOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis

(2009) X Liu et al.   ONCOGENE

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

(2009) X. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

(2009) J. M. Facucho-Oliveira et al.   Stem Cell Reviews and Reports

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

What causes mitochondrial DNA deletions in human cells?

(2008) Kim J Krishnan et al.   NATURE GENETICS

Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

(2008) C. A. Stoltzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of placental protein expression of OLR1: implication in pregnancy-related disorders or pathologies

(2008) M Ethier-Chiasson et al.   REPRODUCTION