Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

Cholesterol and beyond - The role of the mevalonate pathway in cancer biology

(2020) Andy Göbel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells

(2019) Laura Pietrovito et al.   CURRENT CANCER DRUG TARGETS

Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials

(2019) Dao-Kui Xia et al.   Drug Design Development and Therapy

Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB)

(2019) Qing Ma et al.   Biomed Research International

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal-regulated kinase signaling

(2019) Hong Ge et al.   Thoracic Cancer

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma

(2019) Saiful E. Syafruddin et al.   Nature Communications

Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells

(2019) Andy Göbel et al.   Cell Death & Disease

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

(2019) Parthasarathy Seshacharyulu et al.   ONCOGENE

Zoledronic acid for the treatment of prostate cancer

(2019) Antoine Finianos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Zoledronic acid blocks the interaction between breast cancer cells and regulatory T-cells

(2019) Hsien Liu et al.   BMC CANCER

Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans

(2019) Li Che et al.   GUT

Dual regulatory mechanisms of expression and mutation involving metabolism-related genes FDFT1 and UQCR5 during colorectal cancer liver metastasis

(2019) Yu-Shui Ma et al.   Molecular Therapy-Oncolytics

Statins as Potential Therapeutics for Lung Cancer

(2019) Ali Fatehi Hassanabad et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Statins induce cell apoptosis through a modulation of AKT/FOXO1 pathway in prostate cancer cells

(2019) Jun-Li Deng et al.   Cancer Management and Research

Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response

(2019) Grace H McGregor et al.   CANCER RESEARCH

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth

(2019) Josephine S. Kim et al.   GYNECOLOGIC ONCOLOGY

Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells

(2019) Geon-Hee Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing

(2019) Liang Chen et al.   JOURNAL OF LIPID RESEARCH

Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer

(2019) Vidyalakshmi Sethunath et al.   MOLECULAR CANCER RESEARCH

SREBP2 is upregulated in esophageal squamous cell carcinoma and co‑operates with c‑Myc to regulate HMGCR expression

(2019) Chenxi Zhong et al.   Molecular Medicine Reports

LncRNA SNHG16 induces the SREBP2 to promote lipogenesis and enhance the progression of pancreatic cancer

(2019) Yi Yu et al.   Future Oncology

Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence

(2019) Shupei Wei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma

(2019) Beibei Liang et al.   Cell Death & Disease

Targeting the Mevalonate Pathway for Treating Lung Cancer

(2019) Ali Fatehi Hassanabad et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Pitavastatin slows tumor progression and alters urine-derived volatile organic compounds through the mevalonate pathway

(2019) Luqi Wang et al.   FASEB JOURNAL

Mechanisms and regulation of cholesterol homeostasis

(2019) Jie Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Association Between Statin Use After Diagnosis and Mortality Risk in Patients With Esophageal Cancer: A Retrospective Cohort Study of United States Veterans

(2018) Theresa Nguyen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway

(2018) Lin Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Zoledronic acid overcomes chemoresistance by sensitizing cancer stem cells to apoptosis

(2018) H Rouhrazi et al.   BIOTECHNIC & HISTOCHEMISTRY

The poor design of clinical trials of statins in oncology may explain their failure – Lessons for drug repurposing

(2018) Marwan I. Abdullah et al.   CANCER TREATMENT REVIEWS

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

(2018) Bo Wang et al.   Cell Stem Cell

Statins use and cancer: an update

(2018) Martyna Zaleska et al.   Future Oncology

Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma

(2018) Xiaoxia Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Report of the relapsed/refractory cohort of SWOG S0919: A phase 2 study of idarubicin and cytarabine in combination with pravastatin for acute myelogenous leukemia (AML)

(2018) Anjali S. Advani et al.   LEUKEMIA RESEARCH

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Fatostatin suppresses growth and enhances apoptosis by blocking SREBP-regulated metabolic pathways in endometrial carcinoma

(2018) Shuhong Gao et al.   ONCOLOGY REPORTS

Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins

(2018) Federica Iannelli et al.   Recent Patents on Anti-Cancer Drug Discovery

Statins enhance efficacy of venetoclax in blood cancers

(2018) J. Scott Lee et al.   Science Translational Medicine

Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma

(2018) Satoshi Ogura et al.   Oncotarget

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

(2018) Mehdi Dehghani et al.   International Journal of Genomics

Randomized phase III trial to evaluate radiopharmaceuticals and zoledronic acid in the palliation of osteoblastic metastases from lung, breast, and prostate cancer: report of the NRG Oncology RTOG 0517 trial

(2018) Michael J. Seider et al.   ANNALS OF NUCLEAR MEDICINE

MicroRNA-98 regulates hepatic cholesterol metabolism via targeting sterol regulatory element-binding protein 2

(2018) Chong Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer

(2018) Xinhui Kou et al.   CANCER SCIENCE

Inhibition of cholesterol biosynthesis overcomes enzalutamide resistance in castration-resistant prostate cancer (CRPC)

(2018) Yifan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipophilic statins antagonistically alter the major epithelial-to-mesenchymal transition signaling pathways in breast cancer stem-like cells via inhibition of the mevalonate pathway

(2018) Soheila Koohestanimobarhan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DHCR24 predicts poor clinicopathological features of patients with bladder cancer

(2018) Xiao-Ping Liu et al.   MEDICINE

Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer

(2018) Viktor Brovkovych et al.   Oncogenesis

Mevalonate Metabolism in Cancer Stemness and Trained Immunity

(2018) Georg Gruenbacher et al.   Frontiers in Oncology

Role of Androgen Receptor in Prostate Cancer: A Review

(2018) Kazutoshi Fujita et al.   World Journal of Mens Health

SREBP-2 aggravates breast cancer associated osteolysis by promoting osteoclastogenesis and breast cancer metastasis

(2018) Zhiwei Jie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Statins attenuate outgrowth of breast cancer metastases

(2018) Colin H. Beckwitt et al.   BRITISH JOURNAL OF CANCER

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism

(2018) Young-Seon Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes

(2018) Tao Han et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling

(2018) Zhiqiang Zhao et al.   ONCOGENE

Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials

(2018) Mohammed A. M. Farooqi et al.   PLoS One

Cholesterol biosensors: A review

(2018) Vinay Narwal et al.   STEROIDS

Channeling of newly synthesized fatty acids to cholesterol esterification limits triglyceride synthesis in SND1-overexpressing hepatoma cells

(2018) Hiart Navarro-Imaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of statins on cancer mortality and progression: A systematic review and meta-analysis of 95 cohorts including 1,111,407 individuals

(2017) Zubing Mei et al.   INTERNATIONAL JOURNAL OF CANCER

Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study

(2017) Marju Orho-Melander et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Zoledronic Acid in First-Line Treatment of Prostate Cancer

(2017) Michael Pinkawa   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

(2017) Eleonora Ingallina et al.   NATURE CELL BIOLOGY

Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study

(2017) Ming-Szu Hung et al.   PLoS One

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells

(2017) Walaa Eid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

(2017) Sin-Ting Wang et al.   Cell Death & Disease

Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR

(2017) Shingo Ashida et al.   Oncology Letters

SREBP-2-driven transcriptional activation of human SND1 oncogene

(2017) Sandra Armengol et al.   Oncotarget

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma

(2017) Miao Dai et al.   Scientific Reports

Efficacy and safety of lapatinib and trastuzumab for HER2-positive breast cancer: a systematic review and meta-analysis of randomised controlled trials

(2017) Zhi-qiao Xu et al.   BMJ Open

Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

(2017) Ayano Kondo et al.   Cell Reports

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

(2017) Li Zhang et al.   eLife

Statins as Inhibitors of Lung Cancer Bone Metastasis

(2017) Devanand Sarkar   EBioMedicine

Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy

(2017) Zuozhang Yang et al.   EBioMedicine

Mevalonate Pathway and Human Cancers

(2017) Fuyuhiko Tamanoi et al.   Current Molecular Pharmacology

Statin use is associated with improved survival in ovarian cancer: A retrospective population-based study

(2017) Alexandra Couttenier et al.   PLoS One

Combined inhibition of the mevalonate pathway with statins and zoledronic acid potentiates their anti-tumor effects in human breast cancer cells

(2016) Andy Göbel et al.   CANCER LETTERS

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division

(2016) Ankur A. Gholkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

(2016) Yen-Chou Kuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

(2016) Wei Shao (邵威) et al.   JOURNAL OF LIPID RESEARCH

Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data

(2016) Claire L Vale et al.   LANCET ONCOLOGY

The effect of statins on survival in patients with stage IV lung cancer

(2016) Jenny J. Lin et al.   LUNG CANCER

Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma

(2016) Takaaki Higashi et al.   MEDICAL ONCOLOGY

Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations

(2016) CHENGJUN FENG et al.   ONCOLOGY REPORTS

Atorvastatin partially inhibits the epithelial-mesenchymal transition in A549 cells induced by TGF-β1 by attenuating the upregulation of SphK1

(2016) Zhiqiang Fan et al.   ONCOLOGY REPORTS

Bisphosphonates for cancer treatment: Mechanisms of action and lessons from clinical trials

(2016) Heleen H. Van Acker et al.   PHARMACOLOGY & THERAPEUTICS

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

(2016) Udo Walther et al.   Oncotarget

Zoledronic acid impairs stromal reactivity by inhibiting M2-macrophages polarization and prostate cancer-associated fibroblasts

(2016) Giuseppina Comito et al.   Oncotarget

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors

(2016) Joanna Kopecka et al.   Oncotarget

SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer

(2016) Xiangyan Li et al.   Oncotarget

Blood lipids and prostate cancer: a Mendelian randomization analysis

(2016) Caroline J. Bull et al.   Cancer Medicine

The Contribution of Cholesterol and Its Metabolites to the Pathophysiology of Breast Cancer

(2016) Amy E. Baek et al.   Hormones & Cancer

HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes

(2016) Anna Di Benedetto et al.   Scientific Reports

The bisphosphonate zoledronic acid effectively targets lung cancer cells by inhibition of protein prenylation

(2015) Fan Xie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a

(2015) Adam R. Wolfe et al.   BREAST CANCER RESEARCH AND TREATMENT

Mevalonate metabolism in cancer

(2015) Georg Gruenbacher et al.   CANCER LETTERS

The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway

(2015) Yohji Honda et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Simvastatin downregulates expression of TGF-βRII and inhibits proliferation of A549 cells via ERK

(2015) Li Shang et al.   TUMOR BIOLOGY

Effects of zoledronic acid and docetaxel on small GTP-binding proteins in prostate cancer

(2015) Rachel M. Jones et al.   TUMOR BIOLOGY

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

(2015) Daqian Xu et al.   Nature Communications

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway

(2015) Tingting Wang et al.   Oncotarget

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

(2015) Xiangyan Li et al.   Oncotarget

MircoRNA-33a inhibits epithelial-to-mesenchymal transition and metastasis and could be a prognostic marker in non-small cell lung cancer

(2015) Lihua Yang et al.   Scientific Reports

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

(2015) Jonathan W. Haskins et al.   Science Signaling

Squalene Synthase Induces Tumor Necrosis Factor Receptor 1 Enrichment in Lipid Rafts to Promote Lung Cancer Metastasis

(2014) Yi-Fang Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells

(2014) R. Hamm et al.   BIOCHEMICAL PHARMACOLOGY

Desmosterol in Brain Is Elevated because DHCR24 Needs REST for Robust Expression but REST Is Poorly Expressed

(2014) G.S. Tint et al.   DEVELOPMENTAL NEUROSCIENCE

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Simvastatin induces growth inhibition and apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells via upregulation of Notch1 expression

(2014) XIN HUANG et al.   Molecular Medicine Reports

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Cholesterol and breast cancer pathophysiology

(2014) Erik R. Nelson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Zoledronic acid in the treatment of metastatic breast cancer

(2013) Ana Lluch et al.   ANTI-CANCER DRUGS

Statin use is not associated with reduced risk of skin cancer: a meta-analysis

(2013) X Li et al.   BRITISH JOURNAL OF CANCER

Potent antitumor activity of zoledronic acid-induced Vγ9Vδ2 T cells against primary effusion lymphoma

(2013) Hiroki Goto et al.   CANCER LETTERS

Statins: Perspectives in cancer therapeutics

(2013) Laurent Corcos et al.   DIGESTIVE AND LIVER DISEASE

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

(2013) Muhua Yang et al.   JOURNAL OF LIPID RESEARCH

MicroRNA-185 and 342 Inhibit Tumorigenicity and Induce Apoptosis through Blockade of the SREBP Metabolic Pathway in Prostate Cancer Cells

(2013) Xiangyan Li et al.   PLoS One

Stimulation of Osteoclast Formation by RANKL Requires Interferon Regulatory Factor-4 and Is Inhibited by Simvastatin in a Mouse Model of Bone Loss

(2013) Yoshiki Nakashima et al.   PLoS One

HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway

(2013) X-F Qi et al.   Cell Death & Disease

A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products

(2012) James R. Krycer et al.   BIOCHEMICAL JOURNAL

Sterols regulate 3β-hydroxysterol Δ24-reductase (DHCR24) via dual sterol regulatory elements: Cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins

(2012) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Expanding Roles for SREBP in Metabolism

(2012) Wei Shao et al.   Cell Metabolism

Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system

(2012) Yien Che Tsai et al.   MOLECULAR BIOLOGY OF THE CELL

Lack of Effect of Lowering LDL Cholesterol on Cancer: Meta-Analysis of Individual Data from 175,000 People in 27 Randomised Trials of Statin Therapy

(2012)   PLoS One

Lipids and prostate cancer

(2012) Janel Suburu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Role of squalene synthase in prostate cancer risk and the biological aggressiveness of human prostate cancer

(2012) Y Fukuma et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?

(2012) Tilman Todenhöfer et al.   WORLD JOURNAL OF UROLOGY

Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma

(2011) Marek Hus et al.   ANNALS OF HEMATOLOGY

Regulation of the SREBP transcription factors by mTORC1: Figure 1

(2011) Caroline A. Lewis et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)

(2011) Eser J. Zerenturk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Akt acutely activates the cholesterogenic transcription factor SREBP-2

(2011) Winnie Luu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Zoledronic acid for adjuvant use in patients with breast cancer

(2011) Sigrun Ressler et al.   Expert Review of Anticancer Therapy

Zoledronic Acid Induces Autophagic Cell Death in Human Prostate Cancer Cells

(2011) Ji-Fan Lin et al.   JOURNAL OF UROLOGY

Coordinately Regulated Alternative Splicing of Genes Involved in Cholesterol Biosynthesis and Uptake

(2011) Marisa Wong Medina et al.   PLoS One

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of zoledronic acid in the prevention and treatment of osteoporosis

(2011) Louis-Georges Ste-Marie et al.   Clinical Interventions in Aging

Statin Use and the Risk of Liver Cancer: A Population-Based Case–Control Study

(2010) Hui-Fen Chiu et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression

(2010) Ying-Ying Li et al.   ANTI-CANCER DRUGS

Enzymes of the mevalonate pathway of isoprenoid biosynthesis

(2010) Henry M. Miziorko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

(2010) Anna Martirosyan et al.   BMC CANCER

Atorvastatin and Celecoxib in Combination Inhibits the Progression of Androgen-Dependent LNCaP Xenograft Prostate Tumors to Androgen Independence

(2010) X. Zheng et al.   Cancer Prevention Research

Regulation of cholesterol homeostasis by liver X receptors

(2010) Yan-Wei Hu et al.   CLINICA CHIMICA ACTA

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

Simvastatin modulates the adhesion and growth of hepatocellular carcinoma cells via decrease of integrin expression and ROCK

(2010) Relja   INTERNATIONAL JOURNAL OF ONCOLOGY

Anticancer Efficacy of Simvastatin on Prostate Cancer Cells and Tumor Xenografts Is Associated with Inhibition of Akt and Reduced Prostate-Specific Antigen Expression

(2010) S. T. Kochuparambil et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

(2010) T. Horie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of the mevalonate pathway promotes transformation

(2010) J. W. Clendening et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Use of Statins and Risk of Colorectal Cancer: A Population-Based Study

(2009) Harminder Singh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

(2009) Shinji Kamisuki et al.   CHEMISTRY & BIOLOGY

Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway

(2009) R Do et al.   CLINICAL GENETICS

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

(2009) Timothy F. Osborne et al.   GENES & DEVELOPMENT

The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage

(2009) Masato Irisawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell Carcinoma

(2008) J. Woodard et al.   CLINICAL CANCER RESEARCH

Regulation of Cholesterologenesis by the Oxysterol Receptor, LXRα

(2008) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of HMG-CoA reductase expression by hypoxia

(2008) Valentina Pallottini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY