Review
Pharmacology & Pharmacy
Linyuan Yu, Yongliang Zhao, Yongli Zhao
Summary: Rhubarb palmatum L., Polygonum multijiorum Thunb., and Polygonum cuspidatum Sieb. Et Zucc. are traditional Chinese medicines with various pharmacological effects, including promoting lipid and glucose metabolism, osteogenesis, and anti-inflammatory and anti-autophagy effects. Emodin, the main active ingredient in these medicines, shows therapeutic effects on obesity, hyperlipidemia, non-alcoholic fatty liver disease, diabetes and its complications, and osteoporosis by regulating AMPK, PPAR, and inflammation-related signaling pathways. Toxicity control and improved bioavailability are important for the clinical application of emodin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Sabrina Caporali, Alessandro De Stefano, Cinzia Calabrese, Alfredo Giovannelli, Massimo Pieri, Isabella Savini, Manfredi Tesauro, Sergio Bernardini, Marilena Minieri, Alessandro Terrinoni
Summary: Flavonoids are interesting molecules synthesized by plants, with important nutritional and anti-inflammatory properties in the human body. The biochemical properties of flavonoid molecules provide new perspectives for long-term health in healthy individuals, as well as their use as adjunctive treatment for specific diseases.
Article
Psychiatry
Meijuan Li, Ying Liu, Yuying Qiu, Jing Zhang, Yonghui Zhang, Yongping Zhao, Qiong Jia, Jie Li
Summary: This study showed that adjunctive treatment with berberine can reduce the risk of glycolipid metabolic disturbances in patients with schizophrenia, leading to significant declines in total cholesterol, low-density lipoprotein cholesterol, fasting serum insulin, and insulin resistance.
PSYCHIATRY RESEARCH
(2021)
Article
Food Science & Technology
Yanming Ren, Shuifang Mao, Yujun Zeng, Shiguo Chen, Jinhu Tian, Xingqian Ye
Summary: This study demonstrates that pectin from Citrus unshiu Marc. can promote glucose and lipid metabolism by regulating the intestinal flora and changing the SCFA profile, while improving the morphology of the pancreas and adipose tissue.
Article
Integrative & Complementary Medicine
Xian-pei Heng, Zhi-ta Wang, Liang Li, Liu-qing Yang, Su-ping Huang
Summary: Transcriptomics study showed that Dangua Recipe improved glycolipid metabolism by activating Nampt, which was confirmed by gene and protein validation. Additionally, the Nampt blocker GEN-617 reversed the effects, suggesting Nampt activation as a key mechanism of DGR.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Food Science & Technology
Yu-te Zhong, Qiong Shen, Yu-ting Yang, Ruo-bing Zhang, Li-chun Zhao, Wei Li
Summary: In this study, the major dihydrochalcone compound trilobatin (TRI) was purified from sweet tea and its effect in preventing glycolipid metabolism disorder was investigated using a type 2 diabetic mice model induced by a high-fat diet (HFD) combined with streptozotocin (STZ). The results showed that TRI administration improved elevated blood lipids, liver function, fatty liver, glucose metabolism disorders, and insulin sensitivity. Additionally, TRI was found to inhibit AMPK-mediated gluconeogenesis and fatty acid anabolism, suggesting its mechanism in ameliorating glycolipid metabolism disorder.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Jinglong Xue, Xiangyang Li, Jianhui Liu, Yue Zhang, Yujian Sang, Guiqing Zhou, Lihua Ren, Li Jing, Zhixiong Shi, Jialiu Wei, Xianqing Zhou
Summary: This study evaluated the effect of Decabromodiphenyl ethane (DBDPE) on the male reproductive system and demonstrated potential mechanisms of reproductive toxicity. The results showed that DBDPE caused histopathological changes in the testis, reduced sperm quantity and motility, and raised the malformation rate. Moreover, it induced DNA damage, meiotic failure, chromosomal association disorder, glycolipid metabolism disorder, and activated mitochondria-mediated apoptosis pathways in the testes of rats. These findings further highlight the harmful impact of DBDPE on the male reproductive system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Medicine, Research & Experimental
Heng Tang, Qingfu Zeng, Ting Tang, Yunjie Wei, Peng Pu
Summary: The study demonstrated the beneficial effects of Kaempferide on improving glycolipid metabolism disorder induced by high-fat diet in mice, through the activation of PPAR gamma/LXR alpha/ABCA1 and PPARγ/PI3K/AKT pathways for hypolipidemic and hypoglycemic effects, respectively. These findings contribute to understanding the pharmacological actions of Ka and its potential in treating obesity, diabetes, nonalcoholic hepatitis, and other metabolic diseases.
Article
Environmental Sciences
Xinxin Li, Lixiang Feng, Qihui Kuang, Xiong Wang, Jun Yang, Xuan Niu, Likun Gao, Lizhi Huang, Pengcheng Luo, Lili Li
Summary: This study demonstrates that exposure to microplastics (MPs) has adverse effects on liver health in individuals with type 2 diabetes mellitus (T2DM), including disruption of liver structure and function, elevated blood glucose levels, impaired glucose tolerance, and the development of fatty liver. MPs exposure also induces oxidative damage in the liver, disturbs glucose and lipid metabolism, promotes hepatic fibrosis, and influences adaptive thermogenesis in brown fat.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lu Liu, Xiaohua Li
Summary: Both luteolin and magnoflorine have been found to regulate the development of breast cancer and can be easily co-administered. In this study, magnoflorine was found to significantly alter the pharmacokinetic profile of luteolin and enhance its anti-tumor effect, possibly through the inhibition of CYP3A activity.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Environmental Sciences
Guoqi Yu, Jinguo Wang, Yongjie Liu, Tingyu Luo, Xi Meng, Ruiyuan Zhang, Bo Huang, Yan Sun, Jun Zhang
Summary: Emerging epidemiological evidence suggests a potential link between per- and polyfluoroalkyl substances (PFAS) exposure and the disturbance of gestational glucolipid metabolism. This study investigated the glucolipid metabolic changes in pregnant rats exposed to low doses of perfluorooctanesulfonic acid (PFOS) and identified the molecular mechanisms underlying these perturbations.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Mengnan Pan, Feifei Liu, Ke Zhang, Zhongyang Chen, Jiahui Tong, Xiangxiang Wang, Feng Zhou, Hao Xiang
Summary: This study explores the independent and interactive effects of greenness and ambient pollutants on new glycolipid metabolism biomarkers. A national cohort study was conducted among 5085 adults in China, measuring novel glycolipid metabolism biomarkers and exposure levels of greenness and pollutants. The results showed that individuals in low-polluted areas benefited more from greenness compared to those in highly-polluted areas. Additionally, PM2.5 partially mediated the association between greenness and the TyG index. Further research is needed to confirm these findings.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Physical
Luana Malacaria, Chiara La Torre, Emilia Furia, Alessia Fazio, Maria Cristina Caroleo, Erika Cione, Luca Gallelli, Tiziana Marino, Pierluigi Plastina
Summary: This work investigated the complexation of luteolin with Al(III), Fe(III), and Cu(II), revealing that the Fe(III)-Lu complex exhibited the highest antioxidant and anti-inflammatory properties. The computational approach also showed the coordination sites of luteolin with different metal ions.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Haiqing Yang, Yuting Li, Linying Huang, Miaochun Fang, Shun Xu
Summary: This review summarizes the critical role of N6-methyladenine (m6A) modification in glycolipid metabolism and glycolipid metabolic disease (GLMD), focusing on its effects and regulatory mechanisms on glucose and lipid metabolism as well as the development of GLMD.
Article
Chemistry, Medicinal
Philipp Daetwyler, Xiaohua Jiang, Beatrice Wagner, Norbert Varga, Tobias Muehlethaler, Katja Hostettler, Said Rabbani, Oliver Schwardt, Beat Ernst
Summary: The conversion of carbohydrates into ester prodrugs can improve oral availability but may also lead to issues such as oxidation and efflux. Therefore, different modifications of carbohydrates need to be studied comprehensively for their effects.
Review
Food Science & Technology
Zhenyu Wang, Yong Li, Dandan Ma, Maomao Zeng, Zhaojun Wang, Fang Qin, Jie Chen, Mark Christian, Zhiyong He
Summary: Different parts of lotus (Nelumbo nucifera Gaertn.) have medicinal properties due to the presence of active chemicals such as alkaloids. The bioavailability of lotus alkaloids is relatively low, but can be enhanced by technological modification. Research shows that lotus alkaloids have therapeutic and preventive effects on obesity, diabetes, neurodegenerative diseases, cancer, cardiovascular diseases, etc. They also have industrial applications in food, pharmaceutical, and cosmetic sectors.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Zhenyu Wang, Maomao Zeng, Zhaojun Wang, Fang Qin, Yongzhi Wang, Jie Chen, Mark Christian, Zhiyong He
Summary: Fat browning has attracted research interest as a potential treatment for obesity and related metabolic disorders. Polyphenols and gut microecology play crucial roles in converting fat to brown. This review summarizes current knowledge, mostly from mouse models, suggesting that the effects of food phenolics on brown fat activation and white fat browning may be due to their regulation of gut microecology, including microbial profiles, gut metabolites, and gut-derived hormones. Furthermore, potential underlying pathways are also discussed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Jun Guo, Maomao Zeng, Jie Chen
Summary: The interaction between dual-flavours and soy protein isolates (SPI) was studied using different analytical techniques. The results revealed that flavours with different structures have different binding modes with the protein. Competitive and noncompetitive binding were observed, and high concentration multi-flavour binding may induce conformational changes and increase binding sites for other flavours.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Lin Zeng, Zhaojun Wang, Zhiyong He, Maomao Zeng, Fang Qin, Jie Chen
Summary: The physicochemical and heat-induced gel properties of pumpkin seed protein isolates were compared with soybean and pea protein isolates. It was found that pumpkin seed protein isolates had the highest gel strength and showed more significant improvement in gel properties after ultrasound or alkaline treatment.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Danda Ma, Zhenyu Wang, Zhiyong He, Zhaojun Wang, Qiuming Chen, Fang Qin, Maomao Zeng, Jie Chen
Summary: This study demonstrates that pine pollen extract (PPE) can effectively combat alcoholic liver disease (ALD) by alleviating MAPK pathway-mediated oxidative stress and apoptosis. PPE significantly reduces oxidative stress markers and enhances antioxidant capacity, exerting hepatoprotective effects at the cellular level. PPE is a natural and effective agent with hepatoprotective potential.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Zhenyu Wang, Chaoyi Xue, Xuan Wang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He
Summary: Lotus leaf, particularly its component Q3G, can stimulate thermogenesis by activating brown adipocytes through the AMPK and β3-AR signaling pathways. The ethanol extract from lotus leaf contains high levels of polyphenols and flavonoids, with Q3G being the most abundant. The extract promotes mitochondrial biogenesis and fatty acid beta-oxidation, leading to increased energy expenditure.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Ashwani Kumar, P. Nirmal, Mukul Kumar, Anina Jose, Vidisha Tomer, Emel Oz, Charalampos Proestos, Maomao Zeng, Tahra Elobeid, K. Sneha, Fatih Oz
Summary: Recent scientific studies have shown that consuming phytochemicals such as carotenoids, polyphenols, isoprenoids, phytosterols, saponins, dietary fibers, polysaccharides, etc., can offer health benefits including prevention of diabetes, obesity, cancer, cardiovascular diseases, etc. As a result, phytochemicals have gained popularity. Functional foods containing phytochemicals and concentrated forms of phytochemicals, known as nutraceuticals, are now used as preventive measures or treatments for various diseases. The purity and structural stability of these phytochemicals play a crucial role in their health benefits, which depend on factors such as matrix, extraction method, solvent, temperature, and extraction time.
Article
Agriculture, Multidisciplinary
Yong Cheng, Jun Jiang, Qiuming Chen, Zhaojun Wang, Maomao Zeng, Fang Qin, Jie Chen, Zhiyong He
Summary: This study investigated the effects of tempering moisture content (TMC) of wheat and radio-frequency (RF) treatment time on wheat quality. The results showed that RF treatment for 9 min can improve wheat quality when the TMC was 14%, which is beneficial for wheat processing and improvement of wheat flour quality.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Xin Li, Liwei Fu, Zhiyong He, Maomao Zeng, Qiuming Chen, Fang Qin, Zhaojun Wang, Jie Chen
Summary: The effects of protein-glutaminase (PG) on calcium sulphate (CaSO4)-induced gels of soy protein isolate (SPI) with different heat treatment levels were investigated. The mild denaturation of the protein favored the deamidation. Heat treatment increased the SPI particle size, and the degree of deamidation affected the particle size distribution. Deamidation and heat treatment synergistically affected the gel properties of SPI.
Article
Polymer Science
Ziqi Zhao, Zhaojun Wang, Zhiyong He, Maomao Zeng, Jie Chen
Summary: This study aimed to investigate the effects of moisture content, extrusion temperature, screw speed, and cooling die unit temperature on the structural and textural properties of calcium caseinate extrudates. The results showed that increasing moisture content led to a decrease in cutting strength, hardness, and chewiness, while significantly increasing the fibrous degree. Higher extrusion temperature resulted in reduced hardness, springiness, and chewiness, attributed to the reduction in air bubbles. Screw speed had minimal effect on the fiber structure and texture. Low temperature cooling led to damaged structure without mechanical anisotropy due to fast solidification. These findings indicate that manipulating moisture content, extrusion temperature, and cooling die unit temperature can effectively control the structure and texture of calcium caseinate extrudates.
Article
Food Science & Technology
Xuejiao Qie, Zhucheng Yin, Zhen He, Chaoyi Xue, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Zhiyong He
Summary: The study investigated the effect of thermally-induced interactions between beta-casein (beta-CN) and phlorizin (Phl) on the antioxidant activity and bioavailability of Phl. The results showed that Phl and beta-CN interacted mainly through hydrogen bonds and Van der Waals forces. The thermal treatment increased the ABTS values of the beta-CN-Phl complex but had little effect on its FRAP. However, the thermal treatment at 121 degrees C decreased the bioavailability of Phl and weakened the binding strength of Phl-beta-CN.
Article
Food Science & Technology
Yan Ji, Zhaojun Wang, Qian Deng, Jie Chen, Zhiyong He, Maomao Zeng, Fang Qin, Hongyang Pan
Summary: This study investigates the effect of hydrolyzed soy protein isolate (HSPI) as a plasticizer on the structural and mechanical properties of soy protein mixture-wheat gluten (SP-WG) extrudates during high moisture extrusion. HSPI primarily consists of small molecular weight peptides. The addition of HSPI decreases the elastic modulus of the SP-WG blends. Low concentrations of HSPI enhance fibrous appearance and mechanical anisotropy, while higher concentrations result in a compact and brittle structure with isotropic properties. Partial addition of HSPI as a plasticizer promotes the formation of a fibrous structure with enhanced mechanical anisotropy.
Article
Polymer Science
Hongfei Du, Tiantian Huang, Maomao Zeng, Qingwu Shen, Ye Jiao, Wei Quan
Summary: This study evaluated the inhibitory effects of different hydrocolloids on the formation of heterocyclic amines (HAs) and advanced glycation end products (AGEs) using chemical model systems. The results showed that chitosan and pectin were powerful inhibitors against the formation of HAs and AGEs, while other hydrocolloids showed unexpected results in promoting HA formation.
Article
Food Science & Technology
Zhenyu Wang, Chaoyi Xue, Tian Yang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Zhiyong He
Summary: Screening of thermogenic activators in C3H10T1/2 cells showed that lotus leaf ethanol extract (LLE) may have higher activity compared to other ingredients. Further investigation revealed that miquelianin, the main flavonoid compound in LLE, promoted lipolysis, enhanced thermogenic programming, induced brown-like adipocyte formation, and improved mitochondrial quality. It also suppressed mitophagy and mimicked NRF2 signaling.
