Reprogramming of fatty acid metabolism in cancer

Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis

(2019) Alessandro Carrer et al.   Cancer Discovery

A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression

(2019) Francesca R. Auciello et al.   Cancer Discovery

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase

(2019) Gerta Hoxhaj et al.   SCIENCE

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression

(2019) Qi Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

(2019) Jia Wei et al.   NATURE

Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism

(2019) Hiroshi Kuwata et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Glucose-derived acetate and ACSS2 as key players in cisplatin resistance in bladder cancer

(2018) He Wen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

(2018) Jianfeng Huang et al.   CANCER CELL

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

(2018) Cunqi Ye et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer

(2018) Yekaterina Y. Zaytseva et al.   Oncotarget

Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins

(2018) Daniela Heilos et al.   Oncotarget

Synopsis of arachidonic acid metabolism: A review

(2018) Violette Said Hanna et al.   Journal of Advanced Research

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

(2018) Toni Petan et al.   MOLECULES

Histidine catabolism is a major determinant of methotrexate sensitivity

(2018) Naama Kanarek et al.   NATURE

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Hierarchical clustering of activated proteins in the PI3K and MAPK pathways in ER-positive, HER2-negative breast cancer with potential therapeutic consequences

(2018) Dinja T. Kruger et al.   BRITISH JOURNAL OF CANCER

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Relationship between Serum Omega-3 Fatty Acid and Asthma Endpoints

(2018) Shahieda Adams et al.   International Journal of Environmental Research and Public Health

Fatty acid synthase (FASN) as a therapeutic target in breast cancer

(2017) Javier A. Menendez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

(2017) Mark Kin Fai Ma et al.   JOURNAL OF HEPATOLOGY

Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target

(2017) Douglas Buckley et al.   PHARMACOLOGY & THERAPEUTICS

Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma

(2017) Arvin M. Gouw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

(2017) Heather J. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid metabolism in breast cancer subtypes

(2017) Marie E. Monaco   Oncotarget

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

(2017) Althea N. Waldhart et al.   Cell Reports

Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells

(2017) J A Menendez et al.   Oncogenesis

Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy

(2016) Falguni Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders

(2016) Gary D. Lopaschuk   ANNALS OF NUTRITION AND METABOLISM

Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption

(2016) Debra K. Cozzoli et al.   BIOLOGICAL PSYCHIATRY

PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

(2016) Pau Castel et al.   CANCER CELL

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

(2016) Daniel R. Wahl et al.   CANCER RESEARCH

Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

(2016) Weina Zhao et al.   CANCER RESEARCH

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Bempedoic Acid (ETC-1002): an Investigational Inhibitor of ATP Citrate Lyase

(2016) Ozlem Bilen et al.   Current Atherosclerosis Reports

Lipid desaturation - the next step in targeting lipogenesis in cancer?

(2016) Barrie Peck et al.   FEBS Journal

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

(2016) Suyong Choi et al.   NATURE CELL BIOLOGY

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer

(2016) Roman Camarda et al.   NATURE MEDICINE

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis

(2016) Christoph Weigel et al.   Nature Communications

NADPH: new oxygen for the ROS theory of aging

(2016) Pablo J. Fernandez-Marcos et al.   Oncotarget

Betulinic Acid Kills Colon Cancer Stem Cells

(2016) Lisette Potze et al.   Current Stem Cell Research & Therapy

IFN -Dependent Interactions between ICAM-1 and LFA-1 Counteract Prostaglandin E2-Mediated Inhibition of Antitumor CTL Responses

(2016) F. S. Basingab et al.   Cancer Immunology Research

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway

(2015) Hiroshi Kuwata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology

(2015) Aby Grabon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Lysophosphatidic acid signalling in development

(2015) X. Sheng et al.   DEVELOPMENT

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

(2015) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia

(2015) Hernán N. Lemus et al.   Journal of Clinical Lipidology

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

(2015) Heidrun Karlic et al.   Cancer Genetics

Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells

(2015) Valentina Zuckerman et al.   Oncotarget

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src

(2015) Pedro Torres-Ayuso et al.   Oncotarget

Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus

(2014) Maria J. Gutierrez et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase

(2014) Sergey Filippov et al.   CURRENT OPINION IN LIPIDOLOGY

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

(2014) Dmitri Samovski et al.   DIABETES

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

(2014) Daniel Veigel et al.   INTERNATIONAL JOURNAL OF CANCER

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer

(2014) Jessica A. Gasser et al.   MOLECULAR CELL

A Higher Dietary Ratio of Long-Chain Omega-3 to Total Omega-6 Fatty Acids for Prevention of COX-2-Dependent Adenocarcinomas

(2014) James J. DiNicolantonio et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

(2014) Karim Bensaad et al.   Cell Reports

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays

(2013) Semjon Willier et al.   BIOLOGY OF THE CELL

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

(2013) Costas A. Lyssiotis et al.   CELL CYCLE

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

Cellular Fatty Acid Metabolism and Cancer

(2013) Erin Currie et al.   Cell Metabolism

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

(2013) Xin Li et al.   EMBO REPORTS

A Low Dietary Ratio of Omega-6 to Omega-3 Fatty Acids May Delay Progression of Prostate Cancer

(2013) Shruti A. Apte et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes

(2013) Jenifer I. Fenton et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up

(2012) Kashif Shafique et al.   BMC CANCER

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Cholesterol and prostate cancer

(2012) Kristine Pelton et al.   CURRENT OPINION IN PHARMACOLOGY

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

(2012) Amy R. Johnson et al.   IMMUNOLOGICAL REVIEWS

Cancer stem cells

(2012) Zuoren Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Controlling Lipid Fluxes at Glycerol-3-phosphate Acyltransferase Step in Yeast

(2012) Nancy Marr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling in Control of Cell Growth and Metabolism

(2012) P. S. Ward et al.   Cold Spring Harbor Perspectives in Biology

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo lipogenesis in the differentiating human adipocyte can provide all fatty acids necessary for maturation

(2011) Jennifer M. Collins et al.   JOURNAL OF LIPID RESEARCH

Blockade of Fatty Acid Synthase Induces Ubiquitination and Degradation of Phosphoinositide-3-Kinase Signaling Proteins in Ovarian Cancer

(2011) K. Tomek et al.   MOLECULAR CANCER RESEARCH

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Subtype and pathway specific responses to anticancer compounds in breast cancer

(2011) L. M. Heiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The statin-low cholesterol-cancer conundrum

(2011) U. Ravnskov et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

(2010) Daniel E. Frigo et al.   CANCER RESEARCH

De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

(2010) E. Rysman et al.   CANCER RESEARCH

Mammalian diseases of phosphatidylinositol transfer proteins and their homologs

(2010) Aaron H Nile et al.   Clinical Lipidology

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin

(2010) Takashi Yamamoto et al.   JOURNAL OF LIPID RESEARCH

A Phosphatidic Acid Binding/Nuclear Localization Motif Determines Lipin1 Function in Lipid Metabolism and Adipogenesis

(2010) Hongmei Ren et al.   MOLECULAR BIOLOGY OF THE CELL

Inverse relation between FASN expression in human adipose tissue and the insulin resistance level

(2010) María D Mayas et al.   Nutrition & Metabolism

Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

(2009) Kazuharu Takeuchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells

(2009) Thomas W. Grunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives

(2009) Javier A. Menendez   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR

(2009) Alexandros Tzatsos   JOURNAL OF BIOLOGICAL CHEMISTRY

De NovoLipogenesis and Stearoyl-CoA Desaturase Are Coordinately Regulated in the Human Adipocyte and Protect against Palmitate-induced Cell Injury

(2009) Jennifer M. Collins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Somatic LKB1 Mutations Promote Cervical Cancer Progression

(2009) Shana N. Wingo et al.   PLoS One

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Cellular fatty acid uptake: a pathway under construction

(2009) Xiong Su et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis

(2008) Angela A. Wendel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Regulation of Ceramide Biosynthesis by TOR Complex 2

(2008) Sofia Aronova et al.   Cell Metabolism

Lysophosphatidic acid induces cell migration through the selective activation of Akt1

(2008) Eun Kyoung Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

(2008) Artemis P. Simopoulos   EXPERIMENTAL BIOLOGY AND MEDICINE

Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITP  during axonal extension in hippocampal neurons

(2008) K. E. Cosker et al.   JOURNAL OF CELL SCIENCE

Membrane phospholipid synthesis and endoplasmic reticulum function

(2008) Paolo Fagone et al.   JOURNAL OF LIPID RESEARCH

The AIB1 Oncogene Promotes Breast Cancer Metastasis by Activation of PEA3-Mediated Matrix Metalloproteinase 2 (MMP2) and MMP9 Expression

(2008) L. Qin et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin

(2008) A. Toschi et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS