Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase

(2018) Lu-Yi Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

(2018) Yun Xia et al.   CELL

Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis

(2018) Cormac McCarthy et al.   Nature Communications

Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver

(2016) Seonghwan Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

(2016) Marleen Schonewille et al.   JOURNAL OF LIPID RESEARCH

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

An assessment by the Statin Muscle Safety Task Force: 2014 update

(2014) Robert S. Rosenson et al.   Journal of Clinical Lipidology

An assessment by the Statin Diabetes Safety Task Force: 2014 update

(2014) Kevin C. Maki et al.   Journal of Clinical Lipidology

Application of New Cholesterol Guidelines to a Population-Based Sample

(2014) Michael J. Pencina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults

(2013) Neil J. Stone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Statins, risk assessment, and the new American prevention guidelines

(2013) Donald M Lloyd-Jones et al.   LANCET

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

(2013) Pei-Shan Li et al.   NATURE MEDICINE

Statin Use and Musculoskeletal Pain Among Adults With and Without Arthritis

(2012) Catherine Buettner et al.   AMERICAN JOURNAL OF MEDICINE

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

Risk of Incident Diabetes With Intensive-Dose Compared With Moderate-Dose Statin Therapy

(2011) David Preiss   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

(2011) Y. Jo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase

(2010) Youngah Jo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Statin Rebound or Withdrawal Syndrome: Does It Exist?

(2010) Andres Pineda et al.   Current Atherosclerosis Reports

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

The relationship between reduction in low-density lipoprotein cholesterol by statins and reduction in risk of cardiovascular outcomes: An updated meta-analysis

(2009) Philippa J. Delahoy et al.   CLINICAL THERAPEUTICS

When statin therapy stops: implications for the patient

(2009) Stella S Daskalopoulou   CURRENT OPINION IN CARDIOLOGY

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

(2008) Russell A DeBose-Boyd   CELL RESEARCH