The acetyl-CoA carboxylase enzyme: a target for cancer therapy?

Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer

(2014) Yekaterina Y. Zaytseva et al.   CARCINOGENESIS

Regulator of Fatty Acid Metabolism, Acetyl Coenzyme A Carboxylase 1, Controls T Cell Immunity

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Modulation of PI3K-LXRα-dependent lipogenesis mediated by oxidative/nitrosative stress contributes to inhibition of HCV replication by quercetin

(2014) Sandra Pisonero-Vaquero et al.   LABORATORY INVESTIGATION

Increased expression of phospho-acetyl-CoA carboxylase protein is an independent prognostic factor for human gastric cancer without lymph node metastasis

(2014) Wenzhang Fang et al.   MEDICAL ONCOLOGY

The mTOR Inhibitor Rapamycin Synergizes with a Fatty Acid Synthase Inhibitor to Induce Cytotoxicity in ER/HER2-Positive Breast Cancer Cells

(2014) Chen Yan et al.   PLoS One

FAM3A activates PI3K p110α/Akt signaling to ameliorate hepatic gluconeogenesis and lipogenesis

(2013) Chunjiong Wang et al.   HEPATOLOGY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Fatty Acid Synthase Is a Potential Therapeutic Target in Estrogen Receptor-/Progesterone Receptor-Positive Endometrioid Endometrial Cancer

(2013) Mohammed Tanjimur Rahman et al.   ONCOLOGY

Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas

(2012) M T Rahman et al.   BRITISH JOURNAL OF CANCER

Fatty acid synthase expression and esophageal cancer

(2012) Yongli Zhou et al.   MOLECULAR BIOLOGY REPORTS

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status

(2011) Natalya V. Guseva et al.   CANCER BIOLOGY & THERAPY

Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen

(2011) Y. Yamauchi et al.   CANCER RESEARCH

The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation

(2011) Ruben Ghillebert et al.   FEBS Journal

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors

(2010) Claudiu T. Supuran   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High levels of fatty acid synthase expression in esophageal cancers represent a potential target for therapy

(2010) Hajime Orita et al.   CANCER BIOLOGY & THERAPY

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

(2010) Carolyn Algire et al.   ENDOCRINE-RELATED CANCER

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Fatty acid synthase as a novel target for meningioma therapy

(2010) Daniela Haase et al.   NEURO-ONCOLOGY

Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor C93

(2009) Stefanie M. Ueda et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk

(2009) Daniele Campa et al.   BREAST CANCER RESEARCH AND TREATMENT

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

(2009) K Shoji et al.   BRITISH JOURNAL OF CANCER

Metformin is a potent inhibitor of endometrial cancer cell proliferation—implications for a novel treatment strategy

(2009) Leigh A. Cantrell et al.   GYNECOLOGIC ONCOLOGY

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Glucose avidity of carcinomas

(2008) Álvaro D. Ortega et al.   CANCER LETTERS

Cancer biomarker AKR1B10 and carbonyl metabolism

(2008) Ganesaratnam K. Balendiran et al.   CHEMICO-BIOLOGICAL INTERACTIONS

ChREBP: A Glucose-activated Transcription Factor Involved in the Development of Metabolic Syndrome

(2008) Katsumi IIZUKA et al.   ENDOCRINE JOURNAL

In vitro metformin anti-neoplastic activity in epithelial ovarian cancer

(2008) Walter H. Gotlieb et al.   GYNECOLOGIC ONCOLOGY

Fatty Acid Synthase and AKT Pathway Signaling in a Subset of Papillary Thyroid Cancers

(2008) Shahab Uddin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cohort Study of Fatty Acid Synthase Expression and Patient Survival in Colon Cancer

(2008) Shuji Ogino et al.   JOURNAL OF CLINICAL ONCOLOGY

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE