The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD

Vitamin D ‐ liver disease association: Biological basis and mechanisms of action

(2021) Christos Triantos et al.   HEPATOLOGY

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

(2021) Johanna C. Arroyave-Ospina et al.   Antioxidants

LXRα/β Antagonism Protects against Lipid Accumulation in the Liver but Increases Plasma Cholesterol in Rhesus Macaques

(2021) Shengjie Fan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Chronic Western Diets on Non-Alcoholic Fatty Liver of Male Mice Modifying the PPAR-γ Pathway via miR-27b-5p Regulation

(2021) Jian Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism

(2021) Christopher R. Shepard   Frontiers in Endocrinology

Targeting NR4A Nuclear Receptors to Control Stromal Cell Inflammation, Metabolism, Angiogenesis, and Tumorigenesis

(2021) Daniel Crean et al.   Frontiers in Cell and Developmental Biology

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease

(2021) Marc-Olivier Deguise et al.   Cellular and Molecular Gastroenterology and Hepatology

Insights into the Impact of Microbiota in the Treatment of NAFLD/NASH and Its Potential as a Biomarker for Prognosis and Diagnosis

(2021) Julio Plaza-Díaz et al.   Biomedicines

Variations of Serum Oxidative Stress Biomarkers under First-Line Antituberculosis Treatment: A Pilot Study

(2021) Andreea-Daniela Meca et al.   Journal of Personalized Medicine

Inhibition of Estrogen-Related Receptor α Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis

(2021) Chien-yu Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent advances of electrochemical sensors for detecting and monitoring ROS/RNS

(2021) Shuang Zhao et al.   BIOSENSORS & BIOELECTRONICS

SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH)

(2021) Tahereh Komeili-Movahhed et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Clinical impact of sexual dimorphism in non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH)

(2021) Patrizia Burra et al.   LIVER INTERNATIONAL

The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD

(2021) Emmanuel D. Dixon et al.   Genes

Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats

(2021) Xiaolei Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology

(2021) Yu Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Thermally Oxidized Coconut Oil as Fat Source in High-Fat Diet Induces Hepatic Fibrosis in Diabetic Rat Model

(2021) Veena Gopinath et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

(2021) Bethan L. Clifford et al.   Cell Metabolism

Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor

(2021) Yukina Takeichi et al.   DIABETOLOGIA

Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR–Nrf2 pathway

(2021) Yi Zhao et al.   ENVIRONMENTAL POLLUTION

Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway

(2021) Huiyuan Yu et al.   EXPERIMENTAL CELL RESEARCH

Fenofibrate, a PPARα agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy

(2021) Jin Yoo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation

(2021) Victoria L. Slaughter et al.   Scientific Reports

Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules

(2021) Debajyoti Das et al.   Redox Biology

Androgen receptor, neovascularization and liver cancer metastasis

(2021) Morgan W. Feng et al.   JOURNAL OF HEPATOLOGY

The pathophysiological function of non-gastrointestinal farnesoid X receptor

(2021) Nana Yan et al.   PHARMACOLOGY & THERAPEUTICS

Changes in the Global Burden of Chronic Liver Diseases From 2012 to 2017: The Growing Impact of Nonalcoholic Fatty Liver Disease

(2020) James M. Paik et al.   HEPATOLOGY

Epidemiological feature of NAFLD from 1999 to 2018 in China

(2020) Jianghua Zhou et al.   HEPATOLOGY

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

(2020) Donatella Chianelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs

(2020) Yun Hu et al.   RNA Biology

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

(2020) Jiyu Zhou et al.   Nature Communications

Estrogenic control of mitochondrial function

(2020) Carolyn M. Klinge   Redox Biology

Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development

(2020) Zhong Chuanxin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

(2020) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Sex Hormone-Dependent Physiology and Diseases of Liver

(2020) Paulina Kur et al.   International Journal of Environmental Research and Public Health

NAFLD and NASH in postmenopausal women: implications for diagnosis and treatment

(2020) Johanna K DiStefano   ENDOCRINOLOGY

Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling

(2020) Toshiaki Teratani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin prevents endothelial dysfunction in SLE by activating the nuclear receptor retinoic acid-related orphan receptor-α

(2020) Huijing Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

(2020) Estefanía de Gregorio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity and NRF2-mediated cytoprotection: Where is the missing link?

(2020) Liliya V. Vasileva et al.   PHARMACOLOGICAL RESEARCH

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

(2020) Dongyin Guan et al.   SCIENCE

Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis

(2020) Le Thi Thanh Thuy et al.   Clinical and Molecular Hepatology

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

(2020) Qiyi Zhao et al.   CELL

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

(2020) Antje Mohs et al.   JOURNAL OF HEPATOLOGY

Revealing the role of peroxisome proliferator-activated receptor β/δ in nonalcoholic fatty liver disease

(2020) Mohammad Zarei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pharmacological activation of REV-ERBα improves nonalcoholic steatohepatitis by regulating intestinal permeability

(2020) Yinhua Ni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

(2020) Sven Francque et al.   Nature Reviews Gastroenterology & Hepatology

Is vitamin D receptor a druggable target for non-alcoholic steatohepatitis?

(2020) Ying Cao et al.   WORLD JOURNAL OF GASTROENTEROLOGY

New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress

(2020) Domenico Ferro et al.   Nutrients

The Nuclear Orphan Receptor NR2F6 Promotes Hepatic Steatosis through Upregulation of Fatty Acid Transporter CD36

(2020) Bing Zhou et al.   Advanced Science

Mitochondrial dysfunction in fibrotic diseases

(2020) Xinyu Li et al.   Cell Death Discovery

An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

(2020) Sarmistha Saha et al.   MOLECULES

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

(2020) Oren Rom et al.   Science Translational Medicine

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

(2020) Young-Chae Kim et al.   Nature Communications

Deletion of the nuclear receptor RORα in macrophages does not modify the development of obesity, insulin resistance and NASH

(2020) Laurent L’homme et al.   Scientific Reports

Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

(2020) Yang Xiao et al.   Molecular Metabolism

E47 modulates hepatic glucocorticoid action

(2019) M. Charlotte Hemmer et al.   Nature Communications

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

(2019) Natalia Becares et al.   Cell Reports

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin

(2019) Martina Barchitta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

(2019) Abudukadier Abulizi et al.   FASEB JOURNAL

Biological mechanisms and related natural modulators of liver X receptor in nonalcoholic fatty liver disease

(2019) Mingzhu Ni et al.   BIOMEDICINE & PHARMACOTHERAPY

Frontline Science: Concanavalin A‐induced acute hepatitis is attenuated in vitamin D receptor knockout mice with decreased immune cell function

(2019) Naoki Umeda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

(2019) Hui Xia et al.   Frontiers in Endocrinology

Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation

(2019) Fei Chen et al.   HEPATOLOGY

Vitamin D receptor activation in liver macrophages protects against hepatic endoplasmic reticulum stress in mice

(2019) Ying Zhou et al.   HEPATOLOGY

Role of microRNA-122 in hepatic lipid metabolism of the weanling female rat offspring exposed to prenatal and postnatal caloric restriction

(2019) Yun Dai et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

(2019) Lin et al.   Cancers

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis

(2019) Xiaoli Sun et al.   Cell Metabolism

Thiazolidinediones: the Forgotten Diabetes Medications

(2019) Harold E. Lebovitz   Current Diabetes Reports

Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction

(2019) Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice

(2019) Anne-Claire M. F. Martines et al.   Scientific Reports

Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

(2019) Deng et al.   Micromachines

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

(2019) Pablo Fernández-Tussy et al.   Molecular Metabolism

Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice

(2019) Pei Wang et al.   Acta Pharmaceutica Sinica B

Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver

(2019) Don-Kyu Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress

(2019) An Yu et al.   CELLULAR SIGNALLING

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

(2019) Zobair M Younossi et al.   LANCET

Adipocyte-derived Periostin mediates glucocorticoid-induced hepatosteatosis in mice

(2019) Jian Wan et al.   Molecular Metabolism

Hepatic ERα accounts for sex differences in the ability to cope with an excess of dietary lipids

(2019) Clara Meda et al.   Molecular Metabolism

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

(2018) Xinshou Ouyang et al.   Cell Metabolism

Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis

(2018) Kia M. Peters et al.   CURRENT OPINION IN LIPIDOLOGY

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

(2018) Xiantong Zou et al.   HEPATOLOGY

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis

(2018) Wenwen Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis

(2018) Maheul Ploton et al.   JOURNAL OF HEPATOLOGY

Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress

(2018) Jun Liu et al.   Lipids in Health and Disease

Direct effects of thyroid hormones on hepatic lipid metabolism

(2018) Rohit A. Sinha et al.   Nature Reviews Endocrinology

The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions

(2018) Longman Li et al.   Oxidative Medicine and Cellular Longevity

LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

(2018) Nadia Cobo-Vuilleumier et al.   Nature Communications

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

(2018) Sangwon Byun et al.   Nature Communications

Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice

(2018) Amar Bahadur Singh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

REVERBa couples the circadian clock to hepatic glucocorticoid action

(2018) Giorgio Caratti et al.   JOURNAL OF CLINICAL INVESTIGATION

Catalase and nonalcoholic fatty liver disease

(2018) Su-Kyung Shin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease

(2018) Xilin Li et al.   TOXICOLOGY

Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation

(2018) Rachel Wong et al.   Nutrients

Effect of pioglitazone on bone mineral density in patients with nonalcoholic steatohepatitis: A 36-month clinical trial

(2018) Paola Portillo-Sanchez et al.   Journal of Diabetes

Recent Advances in Body-on-a-Chip Systems

(2018) Jong Hwan Sung et al.   ANALYTICAL CHEMISTRY

Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease

(2018) Mathis Grossmann et al.   ENDOCRINE REVIEWS

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

(2018) Hanyong Sun et al.   Nature Communications

Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity

(2018) Xu Chen et al.   Redox Biology

Melatonin-induced demethylation of antioxidant genes increases antioxidant capacity through RORα in cumulus cells of prepubertal lambs

(2018) Yi Fang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease

(2017) Sokrates Stein et al.   JOURNAL OF CLINICAL INVESTIGATION

PARP1-mediated PPARα poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease

(2017) Kun Huang et al.   JOURNAL OF HEPATOLOGY

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)

(2017) David C. Tully et al.   JOURNAL OF MEDICINAL CHEMISTRY

Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress

(2017) Raquel M. Alves-Paiva et al.   LIVER INTERNATIONAL

Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

(2017) Mukul R. Jain et al.   LIVER INTERNATIONAL

LDL-C levels in older people: Cholesterol homeostasis and the free radical theory of ageing converge

(2017) Mark T. Mc Auley et al.   MEDICAL HYPOTHESES

Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary

(2017) Jessika P. Prevatto et al.   Oxidative Medicine and Cellular Longevity

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

(2017) Kyeongkyu Kim et al.   Nature Communications

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction

(2017) Hyeon-Ji Kim et al.   Scientific Reports

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Orphan nuclear receptor ERRγ is a key regulator of human fibrinogen gene expression

(2017) Yaochen Zhang et al.   PLoS One

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

(2016) Rohit Anthony Sinha et al.   Autophagy

Regulation of hepatic energy metabolism by the nuclear receptor PXR

(2016) Jukka Hakkola et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation

(2016) Manuel Roqueta-Rivera et al.   Cell Metabolism

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms

(2016) Yuxiang Zhang et al.   GENES & DEVELOPMENT

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer

(2016) Pan Xu et al.   GENES & DEVELOPMENT

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Joseph S. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis

(2016) Jung-Woo Kang et al.   JOURNAL OF PINEAL RESEARCH

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

(2016) Frederik Nevens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

(2016) Anuradha Rao et al.   Science Translational Medicine

SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions

(2016) Chenxia He et al.   TRENDS IN BIOCHEMICAL SCIENCES

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

(2016) Jiho Jang et al.   Nature Communications

Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock

(2015) Gad Asher et al.   CELL

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux

(2015) M. A. Gillespie et al.   EMBO JOURNAL

AMPK activation by liquiritigenin inhibited oxidative hepatic injury and mitochondrial dysfunction induced by nutrition deprivation as mediated with induction of farnesoid X receptor

(2015) Eun Hye Jung et al.   EUROPEAN JOURNAL OF NUTRITION

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism

(2015) Sang Min Lee et al.   HEPATOLOGY

New cellular and molecular targets for the treatment of portal hypertension

(2015) Jordi Gracia-Sancho et al.   Hepatology International

Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice

(2015) Zhi-Chun Zhang et al.   JOURNAL OF HEPATOLOGY

Hepatic estrogen receptor α improves hepatosteatosis through upregulation of small heterodimer partner

(2015) Xiaolin Wang et al.   JOURNAL OF HEPATOLOGY

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase

(2015) Shiva Shajari et al.   JOURNAL OF PINEAL RESEARCH

Glucocorticoids and non-alcoholic fatty liver disease

(2015) Conor P. Woods et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

(2015) Jinbo Han et al.   NATURE

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prevalence of fatty liver disease and the economy in China: A systematic review

(2015) Jin-Zhou Zhu   WORLD JOURNAL OF GASTROENTEROLOGY

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Farnesoid X receptor: a master regulator of hepatic triglyceride and glucose homeostasis

(2014) Yang Jiao et al.   ACTA PHARMACOLOGICA SINICA

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

(2014) Yong-Hyun Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural characterization of a β-hydroxyacid dehydrogenase from Geobacter sulfurreducens and Geobacter metallireducens with succinic semialdehyde reductase activity

(2014) Yanfeng Zhang et al.   BIOCHIMIE

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

(2014) Sokrates Stein et al.   Cell Metabolism

The First Approved Agent in the Glitazar’s Class: Saroglitazar

(2014) Ritesh Agrawal   CURRENT DRUG TARGETS

Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

(2014) Sang Bong Ahn et al.   DIGESTIVE DISEASES AND SCIENCES

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

Oleic acid modulates mRNA expression of liver X receptor (LXR) and its target genes ABCA1 and SREBP1c in human neutrophils

(2014) María Edith Reyes-Quiroz et al.   EUROPEAN JOURNAL OF NUTRITION

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

(2014) Lay T. Gan et al.   JOURNAL OF HEPATOLOGY

Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal

(2014) Johannes Schmitt et al.   LIVER INTERNATIONAL

Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis

(2014) Emiko Kasahara et al.   REDOX REPORT

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

(2013) Simon W. Beaven et al.   Cell Metabolism

Host Genetic Variants in Obesity-Related Nonalcoholic Fatty Liver Disease

(2013) Rohini Mehta et al.   Clinics in Liver Disease

Peroxisome proliferator-activated receptor δ

(2013) Lazar A. Bojic et al.   CURRENT OPINION IN LIPIDOLOGY

Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis

(2013) Don-Kyu Kim et al.   DIABETES

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

Redefining the major contributors to superoxide production in contracting skeletal muscle. The role of NAD(P)H oxidases

(2013) G. K. Sakellariou et al.   FREE RADICAL RESEARCH

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice

(2013) Yan Lu et al.   GUT

Hepatitis C virus induced up-regulation of microRNA-27: A novel mechanism for hepatic steatosis

(2013) Ragunath Singaravelu et al.   HEPATOLOGY

Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)

(2013) Wahiba Berrabah et al.   HEPATOLOGY

Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis

(2013) Lars P. Bechmann et al.   JOURNAL OF HEPATOLOGY

Hepatic steatosis exacerbated by endoplasmic reticulum stress-mediated downregulation of FXR in aging mice

(2013) Xuelian Xiong et al.   JOURNAL OF HEPATOLOGY

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells

(2013) Radmila Feldmann et al.   NUCLEIC ACIDS RESEARCH

Pathophysiology of Human Visceral Obesity: An Update

(2013) André Tchernof et al.   PHYSIOLOGICAL REVIEWS

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

Nuclear Receptors and Transcription Factors in the Development of Fatty Liver Disease

(2012) Aurore Vluggens et al.   CURRENT DRUG METABOLISM

Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

(2012) V. Sanchez-Valle et al.   CURRENT MEDICINAL CHEMISTRY

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism

(2012) Yi Yin et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Rev-erb  and Rev-erb  coordinately protect the circadian clock and normal metabolic function

(2012) A. Bugge et al.   GENES & DEVELOPMENT

Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus

(2012) Ilaria Barchetta et al.   HEPATOLOGY

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

(2012) Chang Yeop Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

(2012) Holly A. Cyphert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRH-1–dependent glucose sensing determines intermediary metabolism in liver

(2012) Maaike H. Oosterveer et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases

(2012) Zhimin Ou et al.   MOLECULAR ENDOCRINOLOGY

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

A Switch in Hepatic Cortisol Metabolism across the Spectrum of Non Alcoholic Fatty Liver Disease

(2012) Adeeba Ahmed et al.   PLoS One

Glucocorticoid and Estrogen Receptors Are Reduced in Mitochondria of Lung Epithelial Cells in Asthma

(2012) Davina C. M. Simoes et al.   PLoS One

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

PPARs and Lipid Ligands in Inflammation and Metabolism

(2011) Gregory S. Harmon et al.   CHEMICAL REVIEWS

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

Nuclear receptors in liver disease

(2011) Martin Wagner et al.   HEPATOLOGY

Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis

(2011) Eun-Jin Kim et al.   HEPATOLOGY

Mechanism of Action of a Peroxisome Proliferator-Activated Receptor (PPAR)-δ Agonist on Lipoprotein Metabolism in Dyslipidemic Subjects with Central Obesity

(2011) Esther M. M. Ooi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MBX-8025, A Novel Peroxisome Proliferator Receptor-δ Agonist: Lipid and Other Metabolic Effects in Dyslipidemic Overweight Patients Treated with and without Atorvastatin

(2011) Harold E. Bays et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A selective estrogen receptor α agonist ameliorates hepatic steatosis in the male aromatase knockout mouse

(2011) Jenny D Y Chow et al.   JOURNAL OF ENDOCRINOLOGY

A lipid to treat non-alcoholic fatty liver disease – The dawn of ‘lipo-rehabilitation’?

(2011) Q.M. Anstee et al.   JOURNAL OF HEPATOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Fibrates in the Treatment of Dyslipidemias — Time for a Reassessment

(2011) Allison B. Goldfine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor   (PPAR ) activity

(2011) F. Gachon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells

(2010) MJ Perez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of Rats

(2010) Hiroya Sato et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Effect of Fenofibrate and Niacin on Intrahepatic Triglyceride Content, Very Low-Density Lipoprotein Kinetics, and Insulin Action in Obese Subjects with Nonalcoholic Fatty Liver Disease

(2010) Elisa Fabbrini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fenofibrate Reduces Systemic Inflammation Markers Independent of Its Effects on Lipid and Glucose Metabolism in Patients with the Metabolic Syndrome

(2010) Renata Belfort et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice

(2010) Rucha Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

Thyroid hormones induce activation of rat hepatic stellate cells through increased expression of p75 neurotrophin receptor and direct activation of Rho

(2010) Isabel Zvibel et al.   LABORATORY INVESTIGATION

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1

(2010) Hansook Kim Chong et al.   NUCLEIC ACIDS RESEARCH

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

(2009) Kari E. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator

(2009) Virgínia Oliveira-Marques et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear Redox Signaling

(2009) Margarete Lukosz et al.   ANTIOXIDANTS & REDOX SIGNALING

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

(2009) Vlad Ratziu et al.   HEPATOLOGY

Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones

(2009) Seong Hwan Hwahng et al.   HEPATOLOGY

Activation of the Liver X Receptor Stimulates Trans-intestinal Excretion of Plasma Cholesterol

(2009) Jelske N. van der Veen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH

Evolution of Inflammation and White Matter Injury in a Model of Transient Focal Ischemia

(2009) Iska Moxon-Emre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells

(2009) Sara Carbajo-Pescador et al.   JOURNAL OF PINEAL RESEARCH

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms

(2009) O. Araki et al.   MOLECULAR ENDOCRINOLOGY

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

(2009) Gwendal Le Martelot et al.   PLOS BIOLOGY

Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions

(2008) Anne Radenne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Glucocorticoid Receptor Controls Hepatic Dyslipidemia through Hes1

(2008) Ulrike Lemke et al.   Cell Metabolism

Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7 -Hydroxylase Gene Transcription in Human Hepatocytes

(2008) S. Han et al.   DRUG METABOLISM AND DISPOSITION

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

(2008) Vlad Ratziu et al.   GASTROENTEROLOGY

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

Nuclear receptors, mitochondria and lipid metabolism

(2008) William A. Alaynick   MITOCHONDRION

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY