Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

(2020) Xiao Liu et al.   GASTROENTEROLOGY

Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis

(2020) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Obeticholic acid—a new therapy in PBC and NASH

(2020) Roger W Chapman et al.   BRITISH MEDICAL BULLETIN

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

The hepatocyte clock and feeding control chronophysiology of multiple liver cell types

(2020) Dongyin Guan et al.   SCIENCE

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response

(2019) Wenxiang Hu et al.   Cell Stem Cell

HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers

(2019) Hui Ling Ko et al.   Cell Reports

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

(2019) Natalia Becares et al.   Cell Reports

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

(2019) Abudukadier Abulizi et al.   FASEB JOURNAL

Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice

(2019) Daniel Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

LBP-20-VK2809, a Novel Liver-Directed Thyroid Receptor Beta Agonist, Significantly Reduces Liver Fat with Both Low and High Doses in Patients with Non-Alcoholic Fatty Liver Disease: A Phase 2 Randomized, Placebo-Controlled Trial

(2019) Rohit Loomba et al.   JOURNAL OF HEPATOLOGY

SR9009 has REV-ERB–independent effects on cell proliferation and metabolism

(2019) Pieterjan Dierickx et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease

(2019) Hui Xia et al.   Frontiers in Endocrinology

Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice

(2019) Bingning Dong et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists

(2019) Rohit A. Sinha et al.   THYROID

Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study

(2019) Stephen A. Harrison et al.   JOURNAL OF HEPATOLOGY

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Stephen A Harrison et al.   LANCET

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

(2019) Fabiana Quagliarini et al.   MOLECULAR CELL

Role of farnesoid X receptor in hepatic steatosis in nonalcoholic fatty liver disease

(2019) Yingfei Xi et al.   BIOMEDICINE & PHARMACOTHERAPY

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

(2018) An Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Direct effects of thyroid hormones on hepatic lipid metabolism

(2018) Rohit A. Sinha et al.   Nature Reviews Endocrinology

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription

(2018) Yong Hoon Kim et al.   SCIENCE

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes

(2018) Dongyin Guan et al.   CELL

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

(2018) Charlotte L. Scott et al.   IMMUNITY

REVERBa couples the circadian clock to hepatic glucocorticoid action

(2018) Giorgio Caratti et al.   JOURNAL OF CLINICAL INVESTIGATION

Association Between Primary Hypothyroidism and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

(2018) Alessandro Mantovani et al.   THYROID

A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease

(2018) Josephine Skat-Rørdam et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Reproductive Endocrinology of Non-Alcoholic Fatty Liver Disease

(2018) Mathis Grossmann et al.   ENDOCRINE REVIEWS

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

(2018) David G. Thomas et al.   Cell Reports

The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ

(2017) Yuxiang Zhang et al.   GENES & DEVELOPMENT

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

(2017) J. Wesley Pike et al.   JOURNAL OF CLINICAL INVESTIGATION

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor

(2017) Arturo Mendoza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network

(2017) Kyeongkyu Kim et al.   Nature Communications

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Nuclear factor-κB regulates the expression of multiple genes encoding liver transport proteins

(2016) Natarajan Balasubramaniyan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Long-Term Pioglitazone Treatment for Patients With Nonalcoholic Steatohepatitis and Prediabetes or Type 2 Diabetes Mellitus

(2016) Kenneth Cusi et al.   ANNALS OF INTERNAL MEDICINE

Regulation of hepatic energy metabolism by the nuclear receptor PXR

(2016) Jukka Hakkola et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms

(2016) Yuxiang Zhang et al.   GENES & DEVELOPMENT

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

(2016) Ido Goldstein et al.   GENOME RESEARCH

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice

(2016) Yuanyuan Li et al.   HEPATOLOGY

Hepatocyte vitamin D receptor regulates lipid metabolism and mediates experimental diet-induced steatosis

(2016) Milica Bozic et al.   JOURNAL OF HEPATOLOGY

Decreased expression of the glucocorticoid receptor-GILZ pathway in Kupffer cells promotes liver inflammation in obese mice

(2016) Olivier Robert et al.   JOURNAL OF HEPATOLOGY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of farnesoid X receptor downregulates monocyte chemoattractant protein-1 in murine macrophage

(2015) Liangpeng Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Glucocorticoids and non-alcoholic fatty liver disease

(2015) Conor P. Woods et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading

(2015) Bokai Zhu et al.   MOLECULAR CELL

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

(2015) Lars Grøntved et al.   Nature Communications

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis

(2015) Saki Gotoh et al.   Scientific Reports

LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling

(2015) Ayaka Ito et al.   eLife

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms

(2014) Andreas Bitter et al.   ARCHIVES OF TOXICOLOGY

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

(2014) Bin Fang et al.   CELL

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

(2014) Sang Bong Ahn et al.   DIGESTIVE DISEASES AND SCIENCES

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

(2014) D.-H. Kim et al.   EMBO JOURNAL

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

(2014) Michal Pawlak et al.   HEPATOLOGY

Research Resource: Aorta- and Liver-Specific ERα-Binding Patterns and Gene Regulation by Estrogen

(2014) Francesca K. Gordon et al.   MOLECULAR ENDOCRINOLOGY

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes

(2014) Yukimasa Takeda et al.   NUCLEIC ACIDS RESEARCH

Thyroid Hormone Upregulates Zinc-α2-glycoprotein Production in the Liver but Not in Adipose Tissue

(2014) Rafael Simó et al.   PLoS One

PPARγ and the global map of adipogenesis and beyond

(2014) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nuclear receptor Rev-erbα: up, down, and all around

(2014) Logan J. Everett et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease

(2013) Rana L. Smalling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

Prevention of Obesity and Insulin Resistance by Estrogens Requires ER  Activation Function-2 (ER AF-2), Whereas ER AF-1 Is Dispensable

(2013) S. Handgraaf et al.   DIABETES

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

(2013) J. He et al.   DIABETES

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

(2013) Lars Grøntved et al.   EMBO JOURNAL

Free fatty acids repress small heterodimer partner (SHP) activation and adiponectin counteracts bile acid-induced liver injury in superobese patients with nonalcoholic steatohepatitis

(2013) Lars P. Bechmann et al.   HEPATOLOGY

Role of Pregnane X Receptor in Obesity and Glucose Homeostasis in Male Mice

(2013) Krisstonia Spruiell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites

(2013) Jason Gertz et al.   MOLECULAR CELL

Hepatocyte Nuclear Factor 4 Alpha and Farnesoid X Receptor Co-regulates Gene Transcription in Mouse Livers on a Genome-Wide Scale

(2013) Ann M. Thomas et al.   PHARMACEUTICAL RESEARCH

Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR

(2012) Hansook Chong et al.   BMC GENOMICS

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

(2012) Zhaoyu Li et al.   CELL

HNF4α Antagonists Discovered by a High-Throughput Screen for Modulators of the Human Insulin Promoter

(2012) Alice Kiselyuk et al.   CHEMISTRY & BIOLOGY

Vitamin D attenuates high fat diet-induced hepatic steatosis in rats by modulating lipid metabolism

(2012) Yi Yin et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Rev-erb  and Rev-erb  coordinately protect the circadian clock and normal metabolic function

(2012) A. Bugge et al.   GENES & DEVELOPMENT

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice

(2012) Jiyoung Lee et al.   HEPATOLOGY

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

(2012) Yuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Corepressors (NCoR and SMRT) as well as coactivators are recruited to positively regulated 1α,25-dihydroxyvitamin D3-responsive genes

(2012) Mark B. Meyer et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes

(2012) N. Henriette Uhlenhaut et al.   MOLECULAR CELL

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases

(2012) Zhimin Ou et al.   MOLECULAR ENDOCRINOLOGY

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

(2012) Laura A. Solt et al.   NATURE

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

(2012) Han Cho et al.   NATURE

Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR

(2012) Anna C. Calkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PPARG Binding Landscapes in Macrophages Suggest a Genome-Wide Contribution of PU.1 to Divergent PPARG Binding in Human and Mouse

(2012) Sebastian Pott et al.   PLoS One

Tetradian oscillation of estrogen receptor   is necessary to prevent liver lipid deposition

(2012) A. Villa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Action of RORs and their ligands in (patho)physiology

(2012) Laura A. Solt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Nuclear Receptor HNF4α Binding Sequences are Widespread in Alu Repeats

(2011) Eugene Bolotin et al.   BMC GENOMICS

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1

(2011) Sara Della Torre et al.   Cell Metabolism

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Farnesoid X receptor represses hepatic human APOA gene expression

(2011) Indumathi Chennamsetty et al.   JOURNAL OF CLINICAL INVESTIGATION

Heteroatom-Substituted Analogues of Orphan Nuclear Receptor Small Heterodimer Partner Ligand and Apoptosis Inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic Acid

(2011) Zebin Xia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

(2011) Raymond J. Patch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Identification of SR3335 (ML-176): A Synthetic RORα Selective Inverse Agonist

(2010) Naresh Kumar et al.   ACS Chemical Biology

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Intestinal Specific LXR Activation Stimulates Reverse Cholesterol Transport and Protects from Atherosclerosis

(2010) Giuseppe Lo Sasso et al.   Cell Metabolism

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR  in the hepatic acute phase response

(2010) N. Venteclef et al.   GENES & DEVELOPMENT

The homeobox protein Prox1 is a negative modulator of ERR /PGC-1  bioenergetic functions

(2010) A. Charest-Marcotte et al.   GENES & DEVELOPMENT

CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen receptor   by cAMP

(2010) S. Carascossa et al.   GENES & DEVELOPMENT

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats

(2010) Toshiaki Nakano et al.   JOURNAL OF HEPATOLOGY

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor   Function in Adipocytes and Macrophages

(2010) M. I. Lefterova et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1

(2010) Hansook Kim Chong et al.   NUCLEIC ACIDS RESEARCH

ChIPing the cistrome of PXR in mouse liver

(2010) Julia Yue Cui et al.   NUCLEIC ACIDS RESEARCH

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

(2009) Kari E. Wong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Modulation of Retinoic Acid Receptor-related Orphan Receptor α and γ Activity by 7-Oxygenated Sterol Ligands

(2009) Yongjun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis

(2009) Songwen Zhang et al.   JOURNAL OF HEPATOLOGY

Hepatocyte Nuclear Factor 4  Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism

(2009) C. P. Martinez-Jimenez et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct Dysregulation of Lipid Metabolism by Unliganded Thyroid Hormone Receptor Isoforms

(2009) O. Araki et al.   MOLECULAR ENDOCRINOLOGY

PPAR  blocks glucocorticoid receptor  -mediated transactivation but cooperates with the activated glucocorticoid receptor   for transrepression on NF- B

(2009) N. Bougarne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease

(2009) B. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3 genomic and nongenomic actions

(2008) Anne Radenne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

The Glucocorticoid Receptor Controls Hepatic Dyslipidemia through Hes1

(2008) Ulrike Lemke et al.   Cell Metabolism

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH

The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism

(2008) Hélène Duez et al.   Diabetes & Vascular Disease Research

A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease

(2008) C. Fernández-Miranda et al.   DIGESTIVE AND LIVER DISEASE

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Lean Phenotype and Resistance to Diet-Induced Obesity in Vitamin D Receptor Knockout Mice Correlates with Induction of Uncoupling Protein-1 in White Adipose Tissue

(2008) Carmen J. Narvaez et al.   ENDOCRINOLOGY

Thyroid hormone (T3) and TRβ agonist GC-1 inhibit/reverse nonalcoholic fatty liver in rats

(2008) Andrea Perra et al.   FASEB JOURNAL

Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

(2008) Hélène Duez et al.   GASTROENTEROLOGY

Rosiglitazone for Nonalcoholic Steatohepatitis: One-Year Results of the Randomized Placebo-Controlled Fatty Liver Improvement With Rosiglitazone Therapy (FLIRT) Trial

(2008) Vlad Ratziu et al.   GASTROENTEROLOGY

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist

(2008) Edward E. Cable et al.   HEPATOLOGY

Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response

(2008) Yan-Dong Wang et al.   HEPATOLOGY

The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism

(2008) Patrick Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear receptor CAR (NR1I3) regulates serum triglyceride levels under conditions of metabolic stress

(2008) Jodi M. Maglich et al.   JOURNAL OF LIPID RESEARCH

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

(2008) Frank Buttgereit et al.   LANCET

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

Genome-Wide Identification of Estrogen Receptor α-Binding Sites in Mouse Liver

(2007) Hui Gao et al.   MOLECULAR ENDOCRINOLOGY