Role of cytoglobin, a novel radical scavenger, in stellate cell activation and hepatic fibrosis

The Antioxidative Role of Cytoglobin in Podocytes: Implications for a Role in Chronic Kidney Disease

(2020) Elisa B. Randi et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

(2020) Xiao Liu et al.   GASTROENTEROLOGY

Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway

(2019) Hongming Lv et al.   Cell Communication and Signaling

Transforming growth factor β (TGFβ) crosstalk with the unfolded protein response is critical for hepatic stellate cell activation

(2019) Zhikui Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

(2019) Olga Khomich et al.   Cells

Roles of N- and C-terminal domains in the ligand-binding properties of cytoglobin

(2018) Shumpei Hanai et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Strong modulation of nitrite reductase activity of cytoglobin by disulfide bond oxidation: Implications for nitric oxide homeostasis

(2018) Brandon J. Reeder et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor

(2018) Joey De Backer et al.   Redox Biology

Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice

(2018) Nguyen Thi Thanh Hai et al.   Scientific Reports

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

(2017) Paola Fisicaro et al.   NATURE MEDICINE

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

(2017) Xiaoping Liu et al.   Nature Communications

Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice

(2017) Tuong Thi Van Thuy et al.   Scientific Reports

Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NFκB/iNOS Signal Pathway and Nitric Oxide Production

(2017) Shuning Zhang et al.   Scientific Reports

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis

(2016) Varun Chandrashekaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

RORγt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice

(2016) Elke Eggenhofer et al.   JOURNAL OF HEPATOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Role of Oxidative Stress in Liver Health and Disease

(2016) Pablo Muriel et al.   Oxidative Medicine and Cellular Longevity

HCV-Induced Oxidative Stress: Battlefield-Winning Strategy

(2016) Khadija Rebbani et al.   Oxidative Medicine and Cellular Longevity

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

(2016) Sun Woo Sophie Kang et al.   PLoS One

IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner

(2016) Hitoshi Nishizawa et al.   Scientific Reports

Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway

(2015) Le Thi Thanh Thuy et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial dynamics and viral infections: A close nexus

(2015) Mohsin Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism

(2015) Annika Wilhelm et al.   GUT

β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis

(2015) Peri Kocabayoglu et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer

(2015) A Latina et al.   ONCOGENE

3β-Hydroxysterol Δ24-Reductase on the Surface of Hepatitis C Virus-Related Hepatocellular Carcinoma Cells Can Be a Target for Molecular Targeting Therapy

(2015) Makoto Saito et al.   PLoS One

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

(2015) Tian Lan et al.   PLoS One

Early to Phase II drugs currently under investigation for the treatment of liver fibrosis

(2014) Peter Hauff et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

(2014) Hanane Lanaya et al.   NATURE CELL BIOLOGY

Melanoma Transition Is Frequently Accompanied by a Loss of Cytoglobin Expression in Melanocytes: A Novel Expression Site of Cytoglobin

(2014) Yoshihiko Fujita et al.   PLoS One

Nitric oxide is a potential mediator of hepatic inflammation and fibrogenesis in autoimmune hepatitis

(2014) Yavuz Beyazit et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Pathogenic role of oxidative and nitrosative stress in primary biliary cirrhosis

(2014) Ignazio Grattagliano   WORLD JOURNAL OF GASTROENTEROLOGY

Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles

(2013) Xiaoping Liu et al.   FEBS Journal

Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

(2013) Bryan C. Fuchs et al.   HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver

(2013) Hiroyuki Motoyama et al.   LABORATORY INVESTIGATION

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis

(2012) Claudia von Montfort et al.   JOURNAL OF HEPATOLOGY

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

(2012) Tung-Ming Leung et al.   JOURNAL OF HEPATOLOGY

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

(2012) Marco Di Pascoli et al.   JOURNAL OF HEPATOLOGY

Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1

(2012) Makoto Saito et al.   JOURNAL OF MEDICAL VIROLOGY

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(2012) Kunfeng Yan et al.   MOLECULAR MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice

(2011) Le Thi Thanh Thuy et al.   AMERICAN JOURNAL OF PATHOLOGY

Cytoglobin, a Novel Member of the Globin Family, Protects Kidney Fibroblasts against Oxidative Stress under Ischemic Conditions

(2011) Hiroshi Nishi et al.   AMERICAN JOURNAL OF PATHOLOGY

TGF-β in progression of liver disease

(2011) Steven Dooley et al.   CELL AND TISSUE RESEARCH

Cytoglobin: biochemical, functional and clinical perspective of the newest member of the globin family

(2011) Urszula Oleksiewicz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury

(2011) Che-Chang Chan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bariatric Surgery-Induced Weight Loss Reduces Hepatic Lipid Peroxidation Levels and Affects Hepatic Cytochrome P-450 Protein Content

(2010) Lauren N. Bell et al.   ANNALS OF SURGERY

Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

(2010) Eun-Sil Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues

(2010) Marwan Emara et al.   Cancer Cell International

Cytoglobin conformations and disulfide bond formation

(2010) Christophe Lechauve et al.   FEBS Journal

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

Nitric-oxide Dioxygenase Function of Human Cytoglobin with Cellular Reductants and in Rat Hepatocytes

(2010) Anne M. Gardner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes

(2010) Takashi Takano et al.   JOURNAL OF HEPATOLOGY

Leptin inhibits PPARγ gene expression in hepatic stellate cells in the mouse model of liver damage

(2010) Yajun Zhou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax

(2010) A. Avivi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of free radicals in liver diseases

(2009) Pablo Muriel   Hepatology International

Nitric Oxide Plays a Crucial Role in the Development/Progression of Nonalcoholic Steatohepatitis in the Choline-Deficient, l-Amino Acid-Defined Diet-Fed Rat Model

(2008) Koji Fujita et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Analyses of Expression of Cytoglobin by Immunohistochemical Studies in Human Tissues

(2008) Akio Shigematsu et al.   HEMOGLOBIN

Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells

(2008) Samuele De Minicis et al.   HEPATOLOGY

Diversity of Globin Function: Enzymatic, Transport, Storage, and Sensing

(2008) Serge N. Vinogradov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro

(2008) N. J. Hodges et al.   MUTAGENESIS

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

NO Dioxygenase Activity in Hemoglobins Is Ubiquitous In Vitro, but Limited by Reduction In Vivo

(2008) Benoit J. Smagghe et al.   PLoS One