Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways

(2020) Arulkumar Nagappan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway

(2020) Charng-Cherng Chyau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

(2019) Adele Chimento et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer

(2019) Débora Kristina Alves-Fernandes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SIRT1 Modulators in Experimentally Induced Liver Injury

(2019) Hassan Farghali et al.   Oxidative Medicine and Cellular Longevity

Context-Dependent Role of NF-κB Signaling in Primary Liver Cancer—from Tumor Development to Therapeutic Implications

(2019) Carolin Czauderna et al.   Cancers

The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond

(2019) Ke et al.   Cells

Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug?

(2019) Moti L. Kashyap et al.   Journal of Clinical Lipidology

Poly(ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons

(2019) Ping Lu et al.   NEUROPHARMACOLOGY

Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming

(2018) Agnes L.C. Ong et al.   AGEING RESEARCH REVIEWS

Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice

(2018) Jiayou Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsins: Proteases that are vital for survival but can also be fatal

(2018) Seema Patel et al.   BIOMEDICINE & PHARMACOTHERAPY

Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders

(2018) Robert J. Henning et al.   Cardiovascular Toxicology

Niacin modulates macrophage polarization in Parkinson's disease

(2018) Chandramohan Wakade et al.   JOURNAL OF NEUROIMMUNOLOGY

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Protein Kinase CK2: An Emerging Regulator of Immunity

(2018) Sara A. Gibson et al.   TRENDS IN IMMUNOLOGY

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

MicroRNA-378 Promotes Hepatic Inflammation and Fibrosis via Modulation of the NFκB-TNFα Pathway

(2018) Tianpeng Zhang et al.   JOURNAL OF HEPATOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs

(2017) Luyao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic stellate cell activation and pro-fibrogenic signals

(2017) Chandrashekhar R. Gandhi   JOURNAL OF HEPATOLOGY

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway

(2017) Ling-Fang Wang et al.   Lipids in Health and Disease

Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver

(2017) Sung E. Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics

(2017) Hua-Zhong Ying et al.   Molecular Medicine Reports

Diabetes Mellitus and Risk of Hepatocellular Carcinoma

(2017) Xu Li et al.   Biomed Research International

Lysosomal cathepsins and their regulation in aging and neurodegeneration

(2016) Veronika Stoka et al.   AGEING RESEARCH REVIEWS

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

IL-6 pathway in the liver: From physiopathology to therapy

(2016) Dirk Schmidt-Arras et al.   JOURNAL OF HEPATOLOGY

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016)   JOURNAL OF HEPATOLOGY

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation

(2016) Álvaro de Mingo et al.   Cell Death & Disease

Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials

(2016) Tao Zeng et al.   Frontiers in Immunology

Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials

(2015) Yi Ding et al.   CLINICAL NUTRITION

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans*

(2015) Anne J. van der Meer et al.   CRITICAL CARE MEDICINE

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation

(2015) Cristina Bárcena et al.   JOURNAL OF HEPATOLOGY

Interferon regulatory factor 9 is a key mediator of hepatic ischemia/reperfusion injury

(2015) Pi-Xiao Wang et al.   JOURNAL OF HEPATOLOGY

MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1

(2015) Alexandra L. McCubbrey et al.   JOURNAL OF IMMUNOLOGY

Role of NF-κB in the pathogenesis of diabetes and its associated complications

(2014) Sandip Patel et al.   Pharmacological Reports

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the Endothelium

(2013) Zhen Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice

(2013) Xin-An Wang et al.   HEPATOLOGY

Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis

(2013) Partha Mukhopadhyay et al.   HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The ways and means that fine tune Sirt1 activity

(2013) Javier R. Revollo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

(2013) Kazuhiko Higashida et al.   PLOS BIOLOGY

Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers

(2013) Sowmya Venkatasubramanian et al.   Journal of the American Heart Association

Cathepsin Cleavage of Sirtuin 1 in Endothelial Progenitor Cells Mediates Stress-Induced Premature Senescence

(2012) Jun Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells

(2012) Juan Li et al.   BMC MOLECULAR BIOLOGY

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

(2012) Péter Bai et al.   Cell Metabolism

Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition

(2012) Rui-Hong Wang et al.   International Journal of Biological Sciences

Revelations into resveratrol's mechanism

(2012)   NATURE MEDICINE

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes

(2011) Hanna Oppenheimer et al.   ARTHRITIS AND RHEUMATISM

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function

(2011) P. W. Caton et al.   DIABETOLOGIA

Metabolic signals regulate SIRT1 expression

(2011) Angeliki Chalkiadaki et al.   EMBO REPORTS

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

(2011) Lilia G Noriega et al.   EMBO REPORTS

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

(2011) Tom Luedde et al.   Nature Reviews Gastroenterology & Hepatology

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

(2011) Ping Li et al.   NUCLEIC ACIDS RESEARCH

Acidic Sphingomyelinase Controls Hepatic Stellate Cell Activation and in Vivo Liver Fibrogenesis

(2010) Anna Moles et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of apoptosis-associated lysosomal membrane permeabilization

(2010) Ann-Charlotte Johansson et al.   APOPTOSIS

Acetylation of p65 at lysine 314 is important for late NF-κB-dependent gene expression

(2010) Karin M Rothgiesser et al.   BMC GENOMICS

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

(2010) C Oberle et al.   CELL DEATH AND DIFFERENTIATION

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

(2010) João-Bruno Soares et al.   Hepatology International

Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation

(2010) Zhiyong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF- B

(2010) X. D. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1

(2009) Jun-ichi Sakamaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of liver disease: cross-talk between the NF-κB and JNK pathways

(2009) Salvatore Papa et al.   BIOLOGICAL CHEMISTRY

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Protein Kinase CK2 in Health and Disease

(2009) I. Dominguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases

(2009) Shin-ichiro Imai   CURRENT PHARMACEUTICAL DESIGN

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

(2009) H. J. Ko et al.   DIABETES

The hepatitis B viral X protein activates NF-κB signaling pathway through the up-regulation of TBK1

(2009) Hye Rim Kim et al.   FEBS LETTERS

Diet-induced obesity increases NF-κB signaling in reporter mice

(2009) Harald Carlsen et al.   Genes and Nutrition

SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1

(2009) S. B. Rajamohan et al.   MOLECULAR AND CELLULAR BIOLOGY

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential

(2008) Anna Moles et al.   HEPATOLOGY

Resveratrol: One molecule, many targets

(2008) Luciano Pirola et al.   IUBMB LIFE

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies

(2008) Jing-Ting Li et al.   JOURNAL OF GASTROENTEROLOGY

Protein kinase CK2, an important regulator of the inflammatory response?

(2008) Nishi N. Singh et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES