LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Chasing the recipe for a pro-regenerative immune system

(2017) James W. Godwin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

(2016) José Manuel Mellado-Gil et al.   DIABETOLOGIA

Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design

(2016) Molly E Ogle et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Regulatory T cells and skeletal muscle regeneration

(2016) Stefano Schiaffino et al.   FEBS Journal

Human macrophages induce CD4+ Foxp3+ regulatory T cells via binding and re-release of TGF-β

(2016) Angelika Schmidt et al.   IMMUNOLOGY AND CELL BIOLOGY

Environmental risk factors for type 1 diabetes

(2016) Marian Rewers et al.   LANCET

Genetic risk factors for type 1 diabetes

(2016) Flemming Pociot et al.   LANCET

Therapies to Preserve β-Cell Function in Type 1 Diabetes

(2015) Johnny Ludvigsson   DRUGS

LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesis

(2015) Lise Lefèvre et al.   Nature Communications

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

(2015) Petra I. Lorenzo et al.   Scientific Reports

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

(2015) Kimberly G. Riley et al.   Molecular Metabolism

Novel Markers to Delineate Murine M1 and M2 Macrophages

(2015) Kyle A. Jablonski et al.   PLoS One

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Treatment of new onset type 1 diabetes with teplizumab: successes and pitfalls in development

(2014) Nalini K Vudattu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

(2014) Jennifer L Mamrosh et al.   eLife

Anti-caspase-3 preconditioning increases proinsulin secretion and deteriorates posttransplant function of isolated human islets

(2013) Daniel Brandhorst et al.   APOPTOSIS

Soluble Factors Secreted by T Cells Promote  -Cell Proliferation

(2013) E. Dirice et al.   DIABETES

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

(2013) Monica Courtney et al.   PLoS Genetics

IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity

(2012) G. T. Tran et al.   BLOOD

PTGS-2-PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

(2012) A. Vennemann et al.   DIABETES

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice

(2012) R. Parsa et al.   DIABETES

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survival of human islets in microbeads containing high guluronic acid alginate crosslinked with Ca2+and Ba2+

(2012) Meirigeng Qi et al.   XENOTRANSPLANTATION

In Vivo Conditional Pax4 Overexpression in Mature Islet  -Cells Prevents Stress-Induced Hyperglycemia in Mice

(2011) K. H. H. He et al.   DIABETES

The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects β-cells against stress-induced apoptosis

(2011) Mathurin Baquié et al.   HUMAN MOLECULAR GENETICS

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

(2011) Jae Man Lee et al.   NATURE

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Metabolic nuclear receptor signaling and the inflammatory acute phase response

(2011) Nicolas Venteclef et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Emerging actions of the nuclear receptor LRH-1 in the gut

(2010) Pablo J. Fernandez-Marcos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Monocyte Chemoattractant Protein-1 Contributes to Gut Homeostasis and Intestinal Inflammation by Composition of IL-10–Producing Regulatory Macrophage Subset

(2010) Yasuhiro Takada et al.   JOURNAL OF IMMUNOLOGY

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

(2010) M. M. Y. Chan et al.   JOURNAL OF IMMUNOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Multidimensional Gene Set Analysis of Genomic Data

(2010) David Montaner et al.   PLoS One

Liver receptor homolog-1, an emerging metabolic modulator

(2008) Yoon-Kwang Lee   Frontiers in Bioscience-Landmark