Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy

NRF2 in regulating cancer metabolism

(2020) Katarína Smolková et al.   ANTIOXIDANTS & REDOX SIGNALING

Chemical hypoxia induces pro-inflammatory signals in fat-laden hepatocytes and contributes to cellular crosstalk with Kupffer cells through extracellular vesicles

(2020) Alejandra Hernandez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of lipid‐induced macrophage polarization through modulating PPAR‐γ activity affects hepatic lipid metabolism via TLR4/NF‐κB signaling pathway

(2020) Hui‐Min Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Molecular and Mechanistic Insights Based on Gut–Liver Axis: Nutritional Target for Non-Alcoholic Fatty Liver Disease (NAFLD) Improvement

(2020) Yun Ji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Anti-inflammatory Activities of Green Tea Catechins along the Gut-liver Axis in Nonalcoholic Fatty Liver Disease: Lessons Learned from Preclinical and Human Studies

(2020) Joanna K. Hodges et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Oxidative stress is associated with suspected non‐alcoholic fatty liver disease and all‐cause mortality in the general population

(2020) Turtushikh Damba et al.   LIVER INTERNATIONAL

The Importance of the Fatty Acid Transporter L-Carnitine in Non-Alcoholic Fatty Liver Disease (NAFLD)

(2020) Dragana Savic et al.   Nutrients

Health Effects of Coffee: Mechanism Unraveled?

(2020) Hubert Kolb et al.   Nutrients

Extracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells

(2020) Alejandra Hernández et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes

(2020) Yana Geng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Association between serum and dietary antioxidant micronutrients and advanced liver fibrosis in non-alcoholic fatty liver disease: an observational study

(2020) Juliana Moraes Coelho et al.   PeerJ

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

(2020) Maren C. Podszun et al.   Redox Biology

Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and Epigenetic Aspects

(2020) Marina Galicia-Moreno et al.   Antioxidants

Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

(2020) Tharindu L. Suraweera et al.   Antioxidants

Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway

(2020) Jing Fang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function

(2019) Hossein Rafiei et al.   Nutrients

Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

(2019) Muhammad Ikram et al.   MOLECULAR NEUROBIOLOGY

Oxidative Stress and Antioxidant Biomarkers in Clinical and Experimental Models of Non-Alcoholic Fatty Liver Disease

(2019) Ayokanmi Ore et al.   Medicina-Lithuania

Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway

(2019) Wenxi He et al.   DIGESTIVE DISEASES AND SCIENCES

Caffeine programs hepatic SIRT1-related cholesterol synthesis and hypercholesterolemia via A2AR/cAMP/PKA pathway in adult male offspring rats

(2019) Shuwei Hu et al.   TOXICOLOGY

Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial

(2019) Fernando Bril et al.   DIABETES CARE

Dietary vitamin E and C intake is inversely associated with the severity of nonalcoholic fatty liver disease

(2019) Dana Ivancovsky-Wajcman et al.   DIGESTIVE AND LIVER DISEASE

Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients

(2019) Magdalena Świderska et al.   FREE RADICAL RESEARCH

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

(2019) Jan Korbecki et al.   INFLAMMATION RESEARCH

Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats

(2019) Hong‑Miao Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo‐controlled, double‐blind clinical trial

(2019) Makan Cheraghpour et al.   PHYTOTHERAPY RESEARCH

Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine

(2019) Annette Brandt et al.   Scientific Reports

Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart

(2019) Pallavi Mishra et al.   Scientific Reports

Serum Vitamin E Levels of Adults with Nonalcoholic Fatty Liver Disease: An Inverse Relationship with All-Cause Mortality in Non-Diabetic but Not in Pre-Diabetic or Diabetic Subjects

(2019) Peiling Tsou et al.   Journal of Clinical Medicine

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

(2019) Demine et al.   Cells

Chronic inflammatory liver diseases and coffee intake

(2019) Franco Contaldo et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Effect of vitamin E in non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomised controlled trials

(2019) Iram Amanullah et al.   POSTGRADUATE MEDICAL JOURNAL

Protective effect of metformin against palmitate-induced hepatic cell death

(2019) Yana Geng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

(2019) Ye-Ryung Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling pathway in Rhynchocypris lagowski Dybowski

(2019) Dong-Ming Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms

(2019) Xin Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet

(2019) Qian Yu et al.   Molecular Medicine Reports

Dietary lipids, gut microbiota and lipid metabolism

(2019) Marc Schoeler et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids

(2019) Junki Miyamoto et al.   Nature Communications

Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway

(2019) Hossein Hosseini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatic GDF15 is regulated by CHOP of the unfolded protein response and alleviates NAFLD progression in obese mice

(2018) Ding Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

(2018) Audrey Burban et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

(2018) Giovanni Musso et al.   GASTROENTEROLOGY

Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury

(2018) Ameng Shi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis

(2018) Nahum Mendez-Sanchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell‑specific and roasting‑dependent regulation of the Keap1/Nrf2 pathway by coffee extracts

(2018) Alexandros Priftis et al.   Molecular Medicine Reports

Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice

(2018) Bodil Bjørndal et al.   Nutrition & Metabolism

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

(2018) Sha Li et al.   Oxidative Medicine and Cellular Longevity

Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

(2018) Mario Masarone et al.   Oxidative Medicine and Cellular Longevity

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of liraglutide, metformin, and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: a randomized trial

(2018) Wen-Huan Feng et al.   Journal of Diabetes Investigation

Caffeine Promotes Conversion of Palmitic Acid to Palmitoleic Acid by Inducing Expression of fat-5 in Caenorhabditis elegans and scd1 in Mice

(2018) Xiaocui Du et al.   Frontiers in Pharmacology

Endoplasmic Reticulum Stress in Metabolic Disorders

(2018) Rose Ghemrawi et al.   Cells

Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33

(2018) Yan Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Silybin Alleviates Hepatic Steatosis and Fibrosis in NASH Mice by Inhibiting Oxidative Stress and Involvement with the Nf-κB Pathway

(2018) Qiang Ou et al.   DIGESTIVE DISEASES AND SCIENCES

Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro

(2018) Junke Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte

(2018) Jung-Pyo Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

(2018) Marc Foretz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

(2018) Arrigo Cicero et al.   Nutrients

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

(2018) Yuji Ogawa et al.   Scientific Reports

Gut microbiota mediates the anti-obesity effect of calorie restriction in mice

(2018) Shuo Wang et al.   Scientific Reports

Molecular pathways of nonalcoholic fatty liver disease development and progression

(2018) Fernando Bessone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Vitamin E Improves Transplant-free Survival and Hepatic Decompensation among Patients with NASH and Advanced Fibrosis

(2018) Eduardo Vilar-Gomez et al.   HEPATOLOGY

Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver disease by activating peroxisome proliferator-activated receptor α in high-fat-diet-fed C57BL/6J mice

(2018) Hyunghee Lee et al.   INTERNATIONAL JOURNAL OF OBESITY

p62/SQSTM1 – steering the cell through health and disease

(2018) Pablo Sánchez-Martín et al.   JOURNAL OF CELL SCIENCE

Chlorogenic acid against palmitic acid in endoplasmic reticulum stress-mediated apoptosis resulting in protective effect of primary rat hepatocytes

(2018) Yong Zhang et al.   Lipids in Health and Disease

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2018) Konstantin Kazankov et al.   Nature Reviews Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease

(2018) Irene Pierantonelli et al.   TRANSPLANTATION

Chlorogenic acid attenuates high-carbohydrate, high-fat diet–induced cardiovascular, liver, and metabolic changes in rats

(2018) Nikhil S. Bhandarkar et al.   NUTRITION RESEARCH

Coffee consumption and risk of nonalcoholic fatty liver disease

(2017) Karn Wijarnpreecha et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Ceramides and mitochondrial fatty acid oxidation in obesity

(2017) Raquel Fucho et al.   FASEB JOURNAL

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Response to: Comment to “EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease”

(2017) Giulio Marchesini et al.   JOURNAL OF HEPATOLOGY

Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl 4 -induced acute liver injury and LPS-treated RAW264.7 cells

(2017) Xin Chen et al.   TOXICOLOGY LETTERS

Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance

(2017) Joonseok Cho et al.   Nature Communications

Molecular Bases Underlying the Hepatoprotective Effects of Coffee

(2017) Federico Salomone et al.   Nutrients

Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD)

(2017) Qian Chen et al.   Nutrients

Isocaloric Dietary Changes and Non-Alcoholic Fatty Liver Disease in High Cardiometabolic Risk Individuals

(2017) Giuseppe Della Pepa et al.   Nutrients

Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes

(2017) Robin Poole et al.   BMJ-British Medical Journal

Clinical implications of understanding the association between oxidative stress and pediatric NAFLD

(2017) Jake P. Mann et al.   Expert Review of Gastroenterology & Hepatology

Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes

(2017) Robin Poole et al.   BMJ-British Medical Journal

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

(2017) Shunxing Rong et al.   eLife

Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications

(2017) Gianfranca Carta et al.   Frontiers in Physiology

The protective effect of the natural compound hesperetin against fulminant hepatitisin vivoandin vitro

(2016) Xueting Bai et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitigation of 5-fluorouracil–induced liver damage in rats by vitamin C via targeting redox–sensitive transcription factors

(2016) AK Al-Asmari et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

Oxidative stress and lipotoxicity

(2016) Amy K. Hauck et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial genome architecture in non-alcoholic fatty liver disease

(2016) Silvia Sookoian et al.   JOURNAL OF PATHOLOGY

Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet

(2016) Zhenxiong Liu et al.   Molecular Medicine Reports

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

(2016) Sha Li et al.   Oxidative Medicine and Cellular Longevity

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

(2016) Nancy Magee et al.   Biomed Research International

Association between Dietary Vitamin C Intake and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Middle-Aged and Older Adults

(2016) Jie Wei et al.   PLoS One

Molecular Strategies for Targeting Antioxidants to Mitochondria: Therapeutic Implications

(2015) Nadezda Apostolova et al.   ANTIOXIDANTS & REDOX SIGNALING

Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of Non-alcoholic fatty liver disease

(2015) N. U. Ashraf et al.   FREE RADICAL RESEARCH

The gut microbiota and host health: a new clinical frontier

(2015) Julian R Marchesi et al.   GUT

Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells

(2015) Qi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2015) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

(2015) Sílvia S. Chambel et al.   Biomed Research International

Similar Reduction of Cholesterol-Adjusted Vitamin E Serum Levels in Simple Steatosis and Non-Alcoholic Steatohepatitis

(2015) Daniele Pastori et al.   Clinical and Translational Gastroenterology

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

(2014) Madeleen Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of vitamin E on peroxisome proliferator-activated receptor γ and nuclear factor-erythroid 2-related factor 2 in hypercholesterolemia-induced atherosclerosis

(2014) Perinur Bozaykut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010

(2014) Qian Xiao et al.   HEPATOLOGY

Antioxidant and Anti-Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models

(2014) Hamideh Parhiz et al.   PHYTOTHERAPY RESEARCH

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative stress as a crucial factor in liver diseases

(2014) Halina Cichoż-Lach   WORLD JOURNAL OF GASTROENTEROLOGY

Does Vitamin C Deficiency Promote Fatty Liver Disease Development?

(2014) David Ipsen et al.   Nutrients

Metformin in the treatment of non-alcoholic fatty liver disease: safety, efficacy and mechanism

(2014) Samir Rouabhia et al.   Expert Review of Gastroenterology & Hepatology

ER stress and hepatic lipid metabolism

(2014) Huiping Zhou et al.   Frontiers in Genetics

Endoplasmic Reticulum Stress and Nox-Mediated Reactive Oxygen Species Signaling in the Peripheral Vasculature: Potential Role in Hypertension

(2013) Celio X.C. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

ATF4 Protein Deficiency Protects against High Fructose-induced Hypertriglyceridemia in Mice

(2013) Guozhi Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling

(2012) Suneng Fu et al.   Cell Metabolism

IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis

(2012) Shiyu Wang et al.   Cell Metabolism

Hepatic Steatosis and Peroxisomal Fatty Acid Beta-oxidation

(2012) Mustapha Cherkaoui-Malki et al.   CURRENT DRUG METABOLISM

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

(2012) Hao Pan et al.   MEDIATORS OF INFLAMMATION

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Induction of antioxidative Nrf2 gene transcription by coffee in humans: depending on genotype?

(2012) Ute Boettler et al.   MOLECULAR BIOLOGY REPORTS

Differing Endoplasmic Reticulum Stress Response to Excess Lipogenesis versus Lipid Oversupply in Relation to Hepatic Steatosis and Insulin Resistance

(2012) Lu-Ping Ren et al.   PLoS One

Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

(2012) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

The Role of Metformin in the Management of NAFLD

(2011) Angela Mazza et al.   Experimental Diabetes Research

Antioxidants as therapeutic agents for liver disease

(2011) Ashwani K. Singal et al.   LIVER INTERNATIONAL

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

(2011) Emilie Lauressergues et al.   NEUROPHARMACOLOGY

L-carnitine ameliorated fatty liver in high-calorie diet/STZ-induced type 2 diabetic mice by improving mitochondrial function

(2011) Yunqiu Xia et al.   Diabetology & Metabolic Syndrome

Caffeine activates preferentially α1-isoform of 5′AMP-activated protein kinase in rat skeletal muscle

(2010) T. Egawa et al.   Acta Physiologica

l-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis—A Randomized and Controlled Clinical Trial

(2010) Mariano Malaguarnera et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

(2010) Kyle T. Pfaffenbach et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

(2010) Jiansheng Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

The critical role of GRP78 in physiologic and pathologic stress

(2010) Kyle T Pfaffenbach et al.   CURRENT OPINION IN CELL BIOLOGY

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression

(2010) Ute Boettler et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Hydrogen Peroxide in NF-κB Activation: From Inducer to Modulator

(2009) Virgínia Oliveira-Marques et al.   ANTIOXIDANTS & REDOX SIGNALING

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

(2009) Melinda S. Yates et al.   CARCINOGENESIS

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

(2009) Sudhir Chowdhry et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ER Stress and Lipogenesis: A Slippery Slope toward Hepatic Steatosis

(2008) Sana Basseri et al.   DEVELOPMENTAL CELL

Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat

(2008) Giuseppina Mattace Raso et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mouse model of liver ischemia and reperfusion injury: method for studying reactive oxygen and nitrogen metabolites in vivo

(2008) Y ABE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liver lipid metabolism

(2008) P. Nguyen et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Initiation and execution of lipotoxic ER stress in pancreatic  -cells

(2008) D. A. Cunha et al.   JOURNAL OF CELL SCIENCE

NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet

(2008) Y. Tanaka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NF-κB signaling, liver disease and hepatoprotective agents

(2008) B Sun et al.   ONCOGENE

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

(2008) G MUSSO et al.   PROGRESS IN LIPID RESEARCH

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY

Blood oxidative stress markers in non-alcoholic steatohepatitis and how it correlates with diet

(2007) Maiana Verdelho Machado et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY