FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

(2021) Lili Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of intestinal lipid metabolism: current concepts and relevance to disease

(2020) Chih-Wei Ko et al.   Nature Reviews Gastroenterology & Hepatology

Obeticholic acid for the treatment of nonalcoholic steatohepatitis

(2020) Raj A. Shah et al.   Expert Review of Gastroenterology & Hepatology

An integrative systems genetic analysis of mammalian lipid metabolism

(2019) Benjamin L. Parker et al.   NATURE

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

(2019) Samer Al-Dury et al.   JOURNAL OF HEPATOLOGY

Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

(2019) Tiara R. Ahmad et al.   Nature Reviews Endocrinology

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement

(2018) Frédéric Brioude et al.   Nature Reviews Endocrinology

Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis

(2018) Peixiang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice

(2017) Oludemilade Akinrotimi et al.   HEPATOLOGY

RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism

(2017) Elizabeth J. Tarling et al.   JOURNAL OF CLINICAL INVESTIGATION

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children

(2016) David E. Kleiner et al.   Clinics in Liver Disease

An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease

(2016) Frank J. Gonzalez et al.   GASTROENTEROLOGY

Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism

(2016) Ylva Bonde et al.   PLoS One

MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism

(2015) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of essential fatty acids

(2014) Arthur A. Spector et al.   JOURNAL OF LIPID RESEARCH

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

MicroRNA-144 Regulates Hepatic ATP Binding Cassette Transporter A1 and Plasma High-Density Lipoprotein After Activation of the Nuclear Receptor Farnesoid X Receptor

(2013) Thomas Q. de Aguiar Vallim et al.   CIRCULATION RESEARCH

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1−/− mice fed low levels of cholic acid

(2012) Ryan D. Jones et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis inob/obMice

(2012) Yanqiao Zhang et al.   MOLECULAR ENDOCRINOLOGY

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Conformationally constrained farnesoid X receptor (FXR) agonists: Heteroaryl replacements of the naphthalene

(2010) Jonathan Y. Bass et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis

(2009) Kazuharu Takeuchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The enterohepatic circulation of bile acids in mammals: form and functions

(2009) Alan et al.   Frontiers in Bioscience-Landmark

Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine

(2009) Ann M. Thomas et al.   HEPATOLOGY

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

(2009) Yanqiao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism

(2008) Matthew T Flowers et al.   CURRENT OPINION IN LIPIDOLOGY

Loss of small heterodimer partner expression in the liver protects against dyslipidemia

(2008) Helen B. Hartman et al.   JOURNAL OF LIPID RESEARCH