A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study

(2017) L Hodson et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Maresin 1 improves insulin sensitivity and attenuates adipose tissue inflammation in ob/ob and diet-induced obese mice

(2017) Leyre Martínez-Fernández et al.   FASEB JOURNAL

Maresin 1 mitigates liver steatosis in ob/ob and diet-induced obese mice

(2017) L M Laiglesia et al.   INTERNATIONAL JOURNAL OF OBESITY

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery

(2017) Ewgenij Proschak et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction

(2017) Hyeon-Ji Kim et al.   Scientific Reports

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

(2017) Yong-Hyun Han et al.   Cell Reports

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation

(2016) Romain A. Colas et al.   JOURNAL OF IMMUNOLOGY

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

(2016) Tania Quesada-López et al.   Nature Communications

Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes

(2015) Chin-Wei Wang et al.   INFECTION AND IMMUNITY

Double-blind Randomized Placebo-controlled Clinical Trial of Omega 3 Fatty Acids for the Treatment of Diabetic Patients With Nonalcoholic Steatohepatitis

(2015) Srinivasan Dasarathy et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of n-3 fish oil on metabolic and histological parameters in NASH: A double-blind, randomized, placebo-controlled trial

(2015) Curtis K. Argo et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RORα Decreases Oxidative Stress Through the Induction of SOD2 and GPx1 Expression and Thereby Protects Against Nonalcoholic Steatohepatitis in Mice

(2014) Yong-Hyun Han et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study

(2014) Eleonora Scorletti et al.   HEPATOLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Effects of obesity/fatty acids on the expression of GPR120

(2014) Francisca Rodriguez-Pacheco et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids

(2013) Pingping Li et al.   CELL

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease

(2012) Eun-Hee Kim et al.   BIOCHEMICAL PHARMACOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

Regulation of the Human Hydroxysteroid Sulfotransferase (SULT2A1) by RORα and RORγ and Its Potential Relevance to Human Liver Diseases

(2012) Zhimin Ou et al.   MOLECULAR ENDOCRINOLOGY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis

(2011) Eun-Jin Kim et al.   HEPATOLOGY

Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2011) Helen M. Parker et al.   JOURNAL OF HEPATOLOGY

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- Lipoxygenase

(2011) Victor Kenyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expression of retinoic acid-related orphan receptor alpha and its responsive genes in human endometrium regulated by cholesterol sulfate

(2011) Fumiko Zenri et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

Specialized pro-resolving lipid mediators in the inflammatory response: An update

(2010) Gerard Bannenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease

(2010) Marcos Martínez-Clemente et al.   HEPATOLOGY

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Transcriptional Activation of HIF-1 by RORα and its Role in Hypoxia Signaling

(2008) Eun-Jin Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE