Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction

(2019) Jiu Deng et al.   Biomicrofluidics

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

(2019) Alison J. Foster et al.   ARCHIVES OF TOXICOLOGY

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

(2019) Volker M. Lauschke et al.   Biotechnology Journal

Microfluidic Multitissue Platform for Advanced Embryotoxicity Testing In Vitro

(2019) Julia Alicia Boos et al.   Advanced Science

A liver-chip-based alcoholic liver disease model featuring multi-non-parenchymal cells

(2019) Jiu Deng et al.   BIOMEDICAL MICRODEVICES

A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles

(2019) Lei Li et al.   Nanomedicine

Microengineered Bioartificial Liver Chip for Drug Toxicity Screening

(2018) Bahman Delalat et al.   ADVANCED FUNCTIONAL MATERIALS

Gut-liver on a chip towards an in vitro model of hepatic steatosis

(2018) Seung Yeon Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications

(2018) Martí Ortega-Ribera et al.   BIOTECHNOLOGY AND BIOENGINEERING

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Development of a perfusable 3D liver cell cultivation system via bundling-up assembly of cell-laden microfibers

(2018) Yuya Yajima et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip system

(2018) A. Moya et al.   LAB ON A CHIP

Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids

(2018) Li-Dong Ma et al.   LAB ON A CHIP

Polymer coating on a micropillar chip for robust attachment of PuraMatrix peptide hydrogel for 3D hepatic cell culture

(2018) Alexander David Roth et al.   Materials Science & Engineering C-Materials for Biological Applications

The immunology of hepatocellular carcinoma

(2018) Marc Ringelhan et al.   NATURE IMMUNOLOGY

Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment

(2018) Jonathan A. Kyffin et al.   TOXICOLOGY IN VITRO

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

(2018) A. M. Ortega-Prieto et al.   Nature Communications

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

(2018) Young Bok Kang et al.   Scientific Reports

Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications

(2018) Tobias Grix et al.   Genes

A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

(2018) Xiang Li et al.   LAB ON A CHIP

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

(2018) Siming Lu et al.   LAB ON A CHIP

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Assembly of Hepatocyte Spheroids Using Magnetic 3D Cell Culture for CYP450 Inhibition/Induction

(2017) Pujan Desai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fabrication of 3D-culture platform with sandwich architecture for preserving liver-specific functions of hepatocytes using 3D bioprinter

(2017) Kenichi Arai et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

The role of Kupffer cells in hepatic diseases

(2017) Peizhi Li et al.   MOLECULAR IMMUNOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Development of a Patient-Specific 3D-Printed Liver Model for Preoperative Planning

(2017) Marta J. Madurska et al.   Surgical Innovation

Engineered Liver Platforms for Different Phases of Drug Development

(2017) Brenton R. Ware et al.   TRENDS IN BIOTECHNOLOGY

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

(2017) Tomasz Kostrzewski et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cost-effective, personalized, 3D-printed liver model for preoperative planning before laparoscopic liver hemihepatectomy for colorectal cancer metastases

(2017) Jan Sylwester Witowski et al.   International Journal of Computer Assisted Radiology and Surgery

Three-dimensional (3D) printing of mouse primary hepatocytes to generate 3D hepatic structure

(2017) Yohan Kim et al.   Annals of Surgical Treatment and Research

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials-Science & Engineering

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

(2017) Kirstin Meyer et al.   Cell Systems

Liver-Kidney-on-Chip To Study Toxicity of Drug Metabolites

(2017) Jannick Theobald et al.   ACS Biomaterials Science & Engineering

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay

(2016) Chao Ma et al.   ANALYTICAL CHEMISTRY

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A 3D alcoholic liver disease model on a chip

(2016) JaeSeo Lee et al.   Integrative Biology

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

(2016) Jacek R. Wiśniewski et al.   Journal of Proteomics

Engineering a perfusable 3D human liver platform from iPS cells

(2016) Arnout Schepers et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

(2016) Xuanyi Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury

(2016) Amranul Haque et al.   Scientific Reports

Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks

(2016) Patrick M. Misun et al.   Microsystems & Nanoengineering

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

(2016) Manuele Gori et al.   PLoS One

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro

(2015) Mi Jang et al.   Biomicrofluidics

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

(2015) Young Bok Abraham Kang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

(2015) Da Yoon No et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

(2015) Sarada Devi Ramachandran et al.   PLoS One

Three-dimensional cell culture technique and pathophysiology

(2014) Michiya Matsusaki et al.   ADVANCED DRUG DELIVERY REVIEWS

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

The role of Kupffer cells in hepatitis B and hepatitis C virus infections

(2014) Arjan Boltjes et al.   JOURNAL OF HEPATOLOGY

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

(2014) Manjunath Hegde et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

(2013) Chen-Ta Ho et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Interstitial Granulomatous Dermatitis With Arthritis Responding to Tocilizumab

(2012) Stefan Schanz   ARCHIVES OF DERMATOLOGY

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

(2012) Fei Yi et al.   Protein & Cell

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Predictive toxicology using systemic biology and liver microfluidic “on chip” approaches: Application to acetaminophen injury

(2011) Jean-Matthieu Prot et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

A microfluidic 3D hepatocyte chip for drug toxicity testing

(2009) Yi-Chin Toh et al.   LAB ON A CHIP