Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis

Stanniocalcin-1 ameliorates lipopolysaccharide-induced pulmonary oxidative stress, inflammation, and apoptosis in mice

(2014) Shih-En Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced Resistance of Restraint-Stressed Mice to Sepsis

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Adrenocortical Scavenger Receptor Class B Type I Deficiency Exacerbates Endotoxic Shock and Precipitates Sepsis-Induced Mortality in Mice

(2014) Sophie Gilibert et al.   JOURNAL OF IMMUNOLOGY

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucocorticoids attenuate septic acute kidney injury

(2013) Hye Min Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

(2013) D.A. Lowes et al.   BRITISH JOURNAL OF ANAESTHESIA

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

(2013) Christopher J. Hall et al.   Cell Metabolism

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Glutathione reductase is essential for host defense against bacterial infection

(2013) Jing Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sepsis definitions: time for change

(2013) Jean-Louis Vincent et al.   LANCET

A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice

(2013) Donal T. Skelly et al.   PLoS One

Glucocorticoids and their receptors: Insights into specific roles in mitochondria

(2013) Sung-Ryul Lee et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Redox regulation of the immune response

(2013) Johanna M Gostner et al.   REDOX REPORT

Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction

(2012) Marni N. Silverman et al.   Annals of the New York Academy of Sciences

Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways

(2012) Emira Ayroldi et al.   FASEB JOURNAL

Pro-atrial natriuretic peptide (pro-ANP) level in patients with severe sepsis and septic shock: prognostic and diagnostic significance

(2012) M. Lipinska-Gediga et al.   INFECTION

N-acetylcysteine Administration is Associated with Reduced Activation of NF-kB and Preserves Lung Dendritic Cells Function in a Zymosan-Induced Generalized Inflammation Model

(2012) Hong-Wei Wang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro

(2012) Sophie Leow-Dyke et al.   Journal of Neuroinflammation

Overexpression of Mitochondrial Uncoupling Protein 2 Inhibits Inflammatory Cytokines and Activates Cell Survival Factors after Cerebral Ischemia

(2012) Bryan Haines et al.   PLoS One

Systemic Steroids in Severe Sepsis and Septic Shock

(2011) Gourang P. Patel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Glucocorticoids induce mitochondrial gene transcription in HepG2 cells

(2011) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative stress and mitochondrial dysfunction in sepsis

(2011) H.F. Galley   BRITISH JOURNAL OF ANAESTHESIA

Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis*

(2011) Dechaboon Changsirivathanathamrong et al.   CRITICAL CARE MEDICINE

Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway

(2011) Emiko Kasahara et al.   FEBS LETTERS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression

(2011) Wolfram Hoetzenecker et al.   NATURE MEDICINE

Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosis

(2011) Christine Konradi et al.   NEUROBIOLOGY OF DISEASE

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondrial dysfunction in autism spectrum disorders: Cause or effect?

(2010) Luigi Palmieri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Strong exercise stress exacerbates dermatitis in atopic model mice, NC/Nga mice, while proper exercise reduces it

(2010) Kumi Orita et al.   EXPERIMENTAL DERMATOLOGY

Uncoupling protein UCP2: When mitochondrial activity meets immunity

(2010) Yalin Emre et al.   FEBS LETTERS

Increased Glucocorticoid Receptor Expression and Activity Mediate the LPS Resistance of SPRET/EI Mice

(2010) Lien Dejager et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase-Dependent Reactive Oxygen Species Mediate Amplified TLR4 Signaling and Sepsis-Induced Mortality in Nrf2-Deficient Mice

(2010) X. Kong et al.   JOURNAL OF IMMUNOLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Kynurenine is an endothelium-derived relaxing factor produced during inflammation

(2010) Yutang Wang et al.   NATURE MEDICINE

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Dynamic aspects of ascorbic acid metabolism in the circulation: analysis by ascorbate oxidase with a prolongedin vivohalf-life

(2009) Emiko Kasahara et al.   BIOCHEMICAL JOURNAL

Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-κB modulates glucocorticoid receptor and NF-κB signalling in HEK-293 cells

(2009) Anna-Maria G. Psarra et al.   BIOCHEMICAL JOURNAL

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic regulation of mitochondrial function by glucocorticoids

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LOW-DOSE DEXAMETHASONE-SUPPLEMENTED FLUID RESUSCITATION REVERSES ENDOTOXIN-INDUCED ACUTE RENAL FAILURE AND PREVENTS CORTICAL MICROVASCULAR HYPOXIA

(2009) Tanja Johannes et al.   SHOCK

Glucocorticoid receptors and other nuclear transcription factors in mitochondria and possible functions

(2008) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide–peptidoglycan model of sepsis

(2008) Damon A. Lowes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic restraint stress promotes immune suppression through Toll-like receptor 4-mediated phosphoinositide 3-kinase signaling

(2008) Y ZHANG et al.   JOURNAL OF NEUROIMMUNOLOGY

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Genomic and nongenomic effects of glucocorticoids

(2008) Cindy Stahn et al.   Nature clinical practice. Rheumatology

Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages

(2007) Tindaro M. Giardina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS