Article
Endocrinology & Metabolism
Mingfeng Xia, Shunxing Rong, Xiaopeng Zhu, Hongmei Yan, Xinxia Chang, Xiaoyang Sun, Hailuan Zeng, Xiaoming Li, Linshan Zhang, Lingyan Chen, Li Wu, Hui Ma, Yu Hu, Wanyuan He, Jian Gao, Baishen Pan, Xiqi Hu, Huandong Lin, Hua Bian, Xin Gao
Summary: The study reveals an inverse association between circulating osteocalcin levels and non-alcoholic fatty liver disease (NAFLD), with osteocalcin reducing liver lipogenesis by decreasing SREBP-1c expression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Food Science & Technology
Yan Zhang, Xiangming Fang, Fen Shuang, Guoxun Chen
Summary: The study investigated the effects of dexamethasone (Dex) and thyroid hormone T3 on the insulin-stimulated Srebp-1c expression. The results showed that Dex alone reduced the Srebp-1c expression but potentiated its expression when combined with insulin. T3 had no effect on the expressions of Srebp-1c and Pck1. These findings reveal the mutual interaction and regulation between insulin and Dex in regulating the expression levels of genes involved in glucose and fatty acid metabolism in liver cells.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Sheng Qiu, Zerong Liang, Qinan Wu, Miao Wang, Mengliu Yang, Chen Chen, Hongting Zheng, Zhiming Zhu, Ling Li, Gangyi Yang
Summary: The study reveals that Nrf2 deficiency promotes hepatic lipid accumulation by enhancing SREBP-1c activity and attenuating autophagy. Additionally, the Nrf2-LAMP1 interaction plays a crucial role in regulating Nrf2-mediated hepatosteatosis.
Article
Immunology
Hui-Jie Liu, Sheng-Tian Cao, Bao-Ying Wen, Xue Han, Yong Li, Shan Li, Jing Li, Lei Zhang
Summary: The study evaluated the pharmacological effect and action mechanism of Rotundic acid extracted from Ilex rotunda Thunb on non-alcoholic steatohepatitis (NASH). Results showed that RA significantly reduced serum LDL levels, hepatic lipid content, and improved liver inflammation, while enhancing the recovery of gut microbiota and short-chain fatty acids.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Huiling Hu, Nannan Sun, Haiyan Du, Yuqing He, Kunyi Pan, Xiuli Liu, Xiaoxia Lu, Jie Wei, Mianmian Liao, Chaohui Duan
Summary: Previous studies have shown that PLZF plays a role in promoting gluconeogenic gene expression, hepatic glucose output, and consequent hyperglycemia. However, its role in regulating lipid metabolism was unknown. This study revealed that PLZF is an essential regulator of hepatic lipid and glucose metabolism. Overexpression of PLZF in the liver led to fatty liver, inflammation, impaired glucose tolerance, and insulin sensitivity. Knockdown of PLZF in obese mice alleviated hepatic steatosis. The underlying mechanism involved PLZF activating SREBP-1c gene transcription by binding to its promoter fragment, which depended on its interaction with SIRT1 to induce a repressor-to-activator conversion. These findings suggest that modulating PLZF expression in the liver could be a potential therapeutic approach for treating NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Cell Biology
Thuy T. P. Nguyen, Do-Young Kim, Seung-Soon Im, Tae-Il Jeon
Summary: Nonalcoholic fatty liver disease affects a quarter of the global population with its pathogenesis not completely understood. A recent study has shown that SREBF1/SREBP-1c contributes to hepatic lipid accumulation through increased lipid synthesis and decreased lipid degradation mediated by autophagic dysregulation.
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Editorial Material
Biochemistry & Molecular Biology
Jie Lu, Li Dong, Magdalene K. Montgomery
Summary: Fasting induces physiological changes in peripheral tissues, such as the liver, by suppressing the expression and activity of SREBP-1 to conserve glucose for maintaining blood glucose levels. Yoshinori Takeuchi and colleagues provide insights into the regulatory mechanism of SREBP-1 expression during fasting, highlighting the importance of the hypothalamic-pituitary-adrenal axis and glucocorticoid-induced binding of the glucocorticoid receptor to enhancer regions of the KLF15 gene.
Review
Oncology
Qiushi Zhao, Xingyu Lin, Guan Wang
Summary: SREBP-1, a crucial transcription factor, is involved in the metabolic reprogramming of various cancers and can serve as a biomarker for prognosis or drug efficacy in cancer patients. This review discusses the structure, activation, and key upstream signaling pathways of SREBP-1, as well as its potential targets and therapeutic approaches in cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Lu Fan, Hongjuan Niu, Linyi Zhao, Rongfei Yao, Xu He, Binan Lu, Zongran Pang
Summary: The study found that PRD has significant therapeutic effects on aged type 2 diabetes mellitus with non-alcoholic fatty liver disease. After treatment, insulin sensitivity and insulin resistance were improved, and lipid metabolism indexes in the blood and lipid accumulation in the liver tissue were significantly reduced.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Summary: NAFLD and type 2 diabetes are comorbidities of obesity, and targeting hepatic FASN may have therapeutic potential for these obesity-associated metabolic diseases.
Article
Biochemistry & Molecular Biology
Lena Seidemann, Anne Krueger, Victoria Kegel-Huebner, Daniel Seehofer, Georg Damm
Summary: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of end-stage liver disease, with unsatisfactory pharmacological treatment options available. Genistein, a soy isoflavone, shows beneficial effects on lipid metabolism and may be a candidate for NAFLD treatment. In an in vitro model, genistein treatment affects PPAR alpha and SREBP-1c signaling pathways, playing a significant role in hepatic lipid metabolism.
Article
Nanoscience & Nanotechnology
Yuhan Li, Jing-Jun Nie, Yuhui Yang, Jianning Li, Jiarui Li, Xianxian Wu, Xing Liu, Da-Fu Chen, Zhiwei Yang, Fu-Jian Xu, Yi Yang
Summary: The study evaluated the suitability of a redox-unlockable polymeric nanopartide Hep@PGEA vector to deliver MST1 or siMST1 for NAFLD therapy. The results showed that HCP/MST1 significantly improved liver insulin resistance sensitivity, reduced liver damage and lipid accumulation, while HCP/siMST1 exacerbated NAFLD.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Environmental Sciences
Chun Ming How, Vivian Hsiu-Chuan Liao
Summary: This study investigated the obesogenic effects of chronic DEHP exposure and its mechanisms. The results showed that early-life DEHP exposure led to lipid and triglyceride accumulation, mainly attributed to DEHP itself. The developmental stage and exposure timing influenced DEHP-induced TG accumulation, and chronic exposure had the most significant effect. In addition, chronic DEHP exposure altered fatty acid composition and TG by regulating lipogenic genes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Cell Biology
Kumar Ganesan, Cong Xu, Qingqing Liu, Yue Sui, Jianping Chen
Summary: The present study aimed to determine whether hepatic PGC1a promotes BC cell invasion via ERRa. Elevated PGC1a expression was highly associated with a shorter overall survival time in patients with BC. High concentrations of palmitic acid (PA) promoted PGC1a expression and increased BC cell proliferation.
Article
Gastroenterology & Hepatology
Sai Wang, Rilu Feng, Shan Shan Wang, Hui Liu, Chen Shao, Yujia Li, Frederik Link, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Summary: This study investigates the transcriptional regulation of multidrug resistance protein 2 (MRP2) under different pathophysiological conditions and identifies FOXA2 as a potential replacement for FXR in maintaining MRP2 expression in patients with acute liver failure (ALF). The findings suggest that by regulating the expression of FOXA2, it may be possible to prevent hyperbilirubinemia in ALF patients with sepsis.
Article
Multidisciplinary Sciences
Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im
Summary: The study found that fat accumulation and inflammation of proinflammatory M1 macrophages were higher in HFHS-fed SCAP mKO mice compared to control mice. This effect was attributed to a defect in the lipopolysaccharide-mediated increase in SREBP-1a. Mechanistically, SREBP-1a increased the expression of cholesterol 25-hydroxylase transcription, leading to an increase in the production of 25-hydroxycholesterol (25-HC) and subsequent activation of liver X receptor alpha (LXRa), which promoted cholesterol efflux and limited cholesterol accumulation and M1 polarization. The activation of the SCAP-SREBP-1a pathway in macrophages could be a potential therapeutic strategy for controlling cholesterol homeostasis and ameliorating obesity.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soon-Young Na, Ki-Sun Kim, Yoon Seok Jung, Don-Kyu Kim, Jina Kim, Sung Jin Cho, In-Kyu Lee, Jongkyeong Chung, Jeong-Sun Kim, Hueng-Sik Choi
Summary: In this study, we found that GSK5182 stabilizes the ERR gamma protein by inhibiting its ubiquitination and recruiting a corepressor through the AF-2 domain. These findings suggest that GSK5182 regulates ERR gamma by a unique molecular mechanism, increasing the inactive form of ERR gamma via inhibition of ubiquitination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Young-Kook Kim, Yoon Seok Jung, Juhyun Song
Summary: Hepatic encephalopathy (HE) is a chronic metabolic disease with neurological and psychiatric symptoms, and recent studies suggest a positive correlation with Alzheimer's disease (AD). Our study compares the gene expression in an HE mouse model and an AD mouse model, revealing a potential link between HE-associated genes and neuronal dysfunction in AD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wei Luo, Julia Z. Z. Adamska, Chunfeng Li, Rohit Verma, Qing Liu, Thomas Hagan, Florian Wimmers, Shakti Gupta, Yupeng Feng, Wenxia Jiang, Jiehao Zhou, Erika Valore, Yanli Wang, Meera Trisal, Shankar Subramaniam, Timothy F. Osborne, Bali Pulendran
Summary: Our previous study showed that the sterol regulatory binding protein (SREBP) pathway is associated with humoral immune response. We generated mice with specific deletion of SCAP, an essential regulator of SREBP signaling, in B cells or CD11c(+) antigen-presenting cells (APCs). Deletion of SCAP in CD11c(+) APCs had no impact on immune responses, whereas SREBP signaling in B cells was crucial for antibody responses and the development of immune cells. These studies reveal the regulatory role of sterol metabolism in humoral immunity.
Article
Chemistry, Physical
Jong Seok Kim, Seungwon Jung, Hiram Kwak, Yoonjae Han, Suhwan Kim, Jongwoo Lim, Yong Min Lee, Yoon Seok Jung
Summary: A novel halide-sulfide hybrid catholyte design is reported for Ni-rich layered oxide cathodes in all-solid-state Li batteries. The hybrid catholyte consists of Li3YCl6 coatings for protection and Li6PS5Cl as a Li+conductor, which significantly improves the performance of the Li[Ni0.88Co0.11Al0.01]O2 cathodes.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Physical
Ikcheon Na, Hwiho Kim, Sebastian Kunze, Chihyun Nam, Sugeun Jo, Hanbi Choi, Sumin Oh, Eugene Choi, Yong Bae Song, Yoon Seok Jung, Yun Seog Lee, Jongwoo Lim
Summary: Surface-treated thin silicon wafers can function as monolithic, additive-free, electrolyte-free, and void-free electrodes to achieve high areal capacity at room temperature. Grooved silicon wafer electrodes showed reversible (de)lithiation and stable interfacial resistance, enabling homogeneous alloying/dealloying processes during cycling.
ACS ENERGY LETTERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sonam Vadera, Timothy Osborne, Vikas Shah, James A. Stephenson
Summary: This study evaluated the use of vertebral CT attenuation measures to predict osteoporosis in a British population. The findings suggest that routine abdominal CT can be used as an opportunistic screening method for osteoporosis without additional cost or radiation exposure. The thresholds identified in this study are comparable to previous studies in other populations and can guide further investigation.
INSIGHTS INTO IMAGING
(2023)
Editorial Material
Biochemistry & Molecular Biology
Yoon Seok Jung, Yong-Hoon Kim, Kamalakannan Radhakrishnan, Jung-Ran Noh, Jung Hyeon Choi, Hyo-Jin Kim, Jae-Ho Jeong, Steven Dooley, Chul-Ho Lee, Hueng-Sik Choi
Review
Chemistry, Physical
Yong Bae Song, Ki Heon Baeck, Hiram Kwak, Haechannara Lim, Yoon Seok Jung
Summary: This review discusses the design strategies and significance of solid-state electrolyte (SSE) films in all-solid-state batteries (ASSBs) based on sulfide solid electrolytes (SSEs). The study examines the essential components of SSE films, including SSEs, binders, and scaffold or substrate materials, and addresses key characteristics related to ASSB assembly and operation. Various SSE films fabricated using different binders and scaffold or substrate materials are explored, and the importance of establishing test protocols for assessing SSE film performance metrics is highlighted.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Kyu Tae Kim, Jehoon Woo, Young-Soo Kim, Sihyeon Sung, Changhyun Park, Chanhee Lee, Young Joon Park, Hyun-Wook Lee, Kyusung Park, Yoon Seok Jung
Summary: This study demonstrates that ultrathin superhydrophobic protective layers can enhance the stability of air-sensitive electrolytes in all-solid-state batteries and facilitate the recovery of ion conductivity. These findings suggest that superhydrophobic coatings are a promising solution for practical all-solid-state technologies.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Noh-Uk Seo, Kyungmi Kim, Jeongmin Yeo, Seung Jae Kwak, YongJoo Kim, Hyemi Kim, Mi Song Kim, Jeongi Choi, Yoon Seok Jung, Junghyun Chae, Jinho Chang, Jung Hoon Yang
Summary: We demonstrate that covalently attaching a 'hydroxide-philic' functional group to a TEMPO moiety effectively prevents chemical degradation and improves stability in a TEMPO-based aqueous organic redox flow battery. The strong interaction between the oxidized form of TEMPO and OH- was identified as the main cause of molecular decomposition. By designing and synthesizing a TEMPO derivative with a hydroxide-philic functional group, the interaction between OH- and the TEMPO moiety was hindered, resulting in improved stability and cycling performance. The derived MIMAcO-TEMPO showed a significantly reduced capacity decay rate and achieved a record-breaking discharge capacity in a high-concentration aqueous organic redox flow battery.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Biochemistry & Molecular Biology
Danbi Jo, Archana Arjunan, Seoyoon Choi, Yoon Seok Jung, Jihyun Park, Jihoon Jo, Oh Yoen Kim, Juhyun Song
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease worldwide. Oligonol treatment has shown potential in attenuating neuropsychiatric problems and improving memory deficits in the early stage of AD, possibly through enhancing antioxidant response and synaptic plasticity.
Article
Green & Sustainable Science & Technology
Mahander P. P. Singh, Se-Ho Kim, Xuyang Zhou, Hiram Kwak, Alisson Kwiatkowski da Silva, Stoichko Antonov, Leonardo Shoji Aota, Chanwon Jung, Yoon Seok Jung, Baptiste Gault
Summary: This study uses cryogenic atom probe tomography to investigate the surface chemistry changes of cathode materials for Li-ion batteries. The formation of Li2CO3 species on the surface of a LiNi0.8Mn0.1Co0.1O2 (NMC811) cathode material when exposed to air is observed. These findings are crucial for improving cathode synthesis and cell assembly protocols, as well as understanding cathode degradation processes.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chenchen Bian, Xiangtong Yuan, Caihong Zeng, Jian Sun, Gen Kaneko, Hong Ji
Summary: This study investigated the mechanism of docosahexaenoic acid (DHA)-induced apoptosis mediated by mitophagy, using grass carp as an animal model. The results showed that inhibition of mitophagy alleviated apoptosis and eliminated the inhibition of lipid accumulation induced by DHA. Mechanistically, DHA induced mitophagy by activating the PPAR gamma-LC3-BNIP3 pathway. Inhibition of PPAR gamma decreased autophagy-related gene expression and prevented BNIP3/NIX-mediated mitophagy-induced apoptosis, thereby alleviating the inhibition of lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Venkatesan Ramya, Karuppiah Prakash Shyam, Arulanandu Angelmary, Balamuthu Kadalmani
Summary: This study reveals that Lauric acid (LA) exerts an epigenetic regulation and metabolic reprogramming on SH-SY5Y neuroblastoma cells through modulation of lncRNA HOTAIR, remodeling of chromatin H3K4 tri-methylation and regulation of glucose uptake by controlling NF-kappa B activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Zanxia Cao, Liling Zhao, Mingcui Chen, Zhihong Shi, Lei Liu
Summary: This study investigated the translocation process of cholesterol/calcitriol in bacterial membranes and their effects on membrane structure. Calcitriol facilitated water transport across the membrane, while cholesterol had the opposite effect. These findings contribute to a better understanding of the relationship between cholesterol/calcitriol concentrations, lipid bilayer structure, and water permeation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Xiaozhen Guo, Jiawen Wang, Hualing Xu, Yangyang Wang, Yutang Cao, Yingquan Wen, Jiaqi Li, Yameng Liu, Kanglong Wang, Jue Wang, Xianchun Zhong, Chuying Sun, Yongxin Zhang, Jingyi Xu, Cuina Li, Pengxiang Mu, Lingyan Xu, Cen Xie
Summary: This study aims to investigate the role of the gut microbiota-bile acid axis in regulating the diurnal rhythms of metabolic homeostasis and assess the impact of obesity on them. The results show that high fat diet feeding and Leptin gene deficiency disrupt the rhythmic patterns of insulin sensitivity and serum total cholesterol levels. The study provides compelling evidence for the association between diurnal rhythm of insulin sensitivity and gut microbiota-bile acid axis, and elucidates the deleterious effects of obesity on gut microbiome-bile acid metabolism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Luca Capocci, Ludovica Pizzati, Maurizio Forte, Rosita Stanzione, Pamela Scarselli, Alba Di Pardo, Sebastiano Sciarretta, Massimo Volpe, Speranza Rubattu, Vittorio Maglione
Summary: The study found that enzymes involved in sphingolipid metabolism show abnormal expression in the cardiac tissue of hypertensive rat models, which may be related to the susceptibility to cardiac damage.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)