25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

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C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man

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Mechanisms of Antioxidant Induction with High-Dose N-Acetylcysteine in Childhood Cerebral Adrenoleukodystrophy

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Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation

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Defective mitochondrial fission augments NLRP3 inflammasome activation

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NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes

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Interleukin-1 potently contributes to 25-hydroxycholesterol-induced synergistic cytokine production in smooth muscle cell-monocyte interactions

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Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

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25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

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25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

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Inflammasomes and Metabolic Disease

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Pathophysiology of X-linked adrenoleukodystrophy

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Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy

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K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

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The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity

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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

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Oxysterols in the pathogenesis of major chronic diseases

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Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures

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The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells

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Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease

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Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients

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Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

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Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

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The Inflammasomes

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The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

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A role for mitochondria in NLRP3 inflammasome activation

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

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25-Hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3βin PC12 cells

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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