Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction

AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation

(2018) Qi Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

(2018) Varman T. Samuel et al.   Cell Metabolism

Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis

(2018) Zobair M. Younossi et al.   HEPATOLOGY

Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future

(2018) Ana Ruth Araújo et al.   LIVER INTERNATIONAL

A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice

(2018) Liang Xu et al.   Oncotarget

Hepatic mitochondrial defects in a mouse model of NAFLD are associated with increased degradation of oxidative phosphorylation subunits.

(2018) Kwangwon Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Prevalence of Nonalcoholic Fatty Liver Disease in Children with Obesity

(2018) Elizabeth L. Yu et al.   JOURNAL OF PEDIATRICS

High prevalence of non-alcoholic fatty liver disease and metabolic risk factors in Guatemala: A population-based study

(2018) A. Rivera-Andrade et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity

(2017) Deqiang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

(2017) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Sulforaphane Protects against High Cholesterol-Induced Mitochondrial Bioenergetics Impairments, Inflammation, and Oxidative Stress and Preserves Pancreaticβ-Cells Function

(2017) Catalina Carrasco-Pozo et al.   Oxidative Medicine and Cellular Longevity

Macrophage function in obesity-induced inflammation and insulin resistance

(2017) Mario A. R. Lauterbach et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

(2017) Eri Kubo et al.   Scientific Reports

Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission

(2017) Gary B. O'Mealey et al.   Redox Biology

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

(2017) Liang Xu et al.   EBioMedicine

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children

(2016) David E. Kleiner et al.   Clinics in Liver Disease

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease

(2016) Sabina Paglialunga et al.   Lipids in Health and Disease

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due toPNPLA3Sequence Variant

(2015) Rosellina M. Mancina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening

(2015) Xueyao Yin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sulforaphane is anticonvulsant and improves mitochondrial function

(2015) Catalina Carrasco-Pozo et al.   JOURNAL OF NEUROCHEMISTRY

A Glance at… Broccoli, glucoraphanin, and sulforaphane

(2015) Michael J. Glade et al.   NUTRITION

Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects

(2015) Masahiro Kikuchi   WORLD JOURNAL OF GASTROENTEROLOGY

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

(2014) Peter Dietrich et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Role of the PNPLA3 I148M Polymorphism in Nonalcoholic Fatty Liver Disease and Fibrosis in Korea

(2014) Sang Soo Lee et al.   DIGESTIVE DISEASES AND SCIENCES

TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

(2014) H. Mahdessian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity and the liver: nonalcoholic fatty liver disease

(2014) Sean W.P. Koppe   Translational Research

Macrophage Polarization in Obesity and Type 2 Diabetes: Weighing Down Our Understanding of Macrophage Function?

(2014) Michael James Kraakman et al.   Frontiers in Immunology

A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function

(2013) Charlotte N Armah et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The role of mitochondrial function and cellular bioenergetics in ageing and disease

(2013) M.D. Brand et al.   BRITISH JOURNAL OF DERMATOLOGY

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Role of PPARs in inflammatory processes associated with metabolic syndrome (Review)

(2013) EDUARDO FUENTES et al.   Molecular Medicine Reports

The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin Resistance

(2013) Hyun-Ae Seo et al.   Oxidative Medicine and Cellular Longevity

Implication of inflammatory signaling pathways in obesity-induced insulin resistance

(2013) Jean-François Tanti et al.   Frontiers in Endocrinology

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

(2012) Akshaya K. Meher et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

Adaptive immunity in obesity and insulin resistance

(2012) Henrike Sell et al.   Nature Reviews Endocrinology

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China

(2011) Thomas W. Kensler et al.   CARCINOGENESIS

Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

(2011) Nicola Santoro et al.   HEPATOLOGY

Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet

(2011) Gaetano Serviddio et al.   PLoS One

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Effect of a 12-Month Intensive Lifestyle Intervention on Hepatic Steatosis in Adults With Type 2 Diabetes

(2010) M. Lazo et al.   DIABETES CARE

Obesity, Diabetes, and Gut Microbiota: The hygiene hypothesis expanded?

(2010) G. Musso et al.   DIABETES CARE

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice

(2010) Z. Yu et al.   DIABETOLOGIA

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome

(2010) Jung Sub Lim et al.   Nature Reviews Gastroenterology & Hepatology

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Epidemiology and Natural History of Non-Alcoholic Steatohepatitis

(2009) Curtis K. Argo et al.   Clinics in Liver Disease

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide

(2009) Soona Shin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Differential alterations in mitochondrial function induced by a choline-deficient diet: Understanding fatty liver disease progression

(2008) João S. Teodoro et al.   MITOCHONDRION